Dithiolanes
eMolecules Broadpharm / alpha-lipoic acid-NHS / 500mg / 268504916 / BP-22515 / 95.000 / 40846-94-4 / MFCD09028032 / 303.390 / C12H17NO4S2
Broadpharm / alpha-lipoic acid-NHS / 500mg / 268504916 / BP-22515 / 95.000 / 40846-94-4 / MFCD09028032 / 303.390 / C12H17NO4S2
Medchemexpress LLC α-Lipoic Acid (Thioctic acid) | 1077-28-7 | MFCD00005474 | 206.33 | 1 ML
α-Lipoic Acid (Thioctic acid) is an antioxidant and an essential cofactor of mitochondrial enzyme complexes. It inhibits NF-κB-dependent HIV-1 LTR activation and induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. It can also be used with CPUL1 (HY-151802) to form self-assembled nanoaggregate CPUL1-LA NA, which shows improved antitumor efficacy compared to CPUL1. This product is for research use only.
- Plays an essential role in mitochondrial bioenergetics.
- Reduces lipid accumulation in the liver.
- Increases NAD+/NADH ratio in HepG2 cells.
- Increases SIRT1 activity in HepG2 cells.
- Increases phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in HepG2 cells.
- Markedly reduces visceral fat mass in C57BL/6J mice.
- Inhibits appetite and causes significant weight loss in mice.
Cayman Chemical R-a-LIpoIc AcId 25g
A cyclic disulfide antioxidant; acts as a cofactor in 2-oxo dehydrogenase complex reactions and is reduced to DHLA; decreases serum levels of MDA and increases the activity of SOD and T-AOC in a mouse model of D-galactose-induced accelerated senescence at 100 mg/kg per day; reduces the escape latency in the Morris water maze compared to both D-galactose and vehicle control groups and rescues decreases in neural progenitor cell proliferation in the hippocampal dentate gyrus at 100 mg/kg per day
Medchemexpress LLC (S)-thioctic acid | 1077-27-6 | MFCD01863481 | 99.8% | 206.33 | C8H14O2S2 | 5 G
(S)-Thioctic acid is the S-enantiomer of lipoic (thioctic) acid supplied as a research-grade biochemical reagent. It acts as an organosulfur antioxidant and a cofactor analogue, suitable for biochemical assays, stereospecific studies, and analytical characterization.
- High chemical purity (99.79%).
- Chiral S-enantiomer for stereospecific studies.
- Solid form, light yellow to yellow appearance.
- Suitable for biochemical assays and antioxidant research.
- Powder storage: -20°C (3 years) or 4°C (2 years).
- Includes COA, SDS, and spectral data for quality verification.
Selleck Chemical LLC ()-a-Lipoic acid S3998-25mg
( )- -Lipoic acid ((R)-( )- -Lipoic acid -Lipoic acid Alpha-Lipoic acid) a physiological form of thioctic acid is a strong antioxidant that relieves diabetic neuropathic symptoms It shows superior antioxidative effects to its racemate R( )- -lipoic acid is an essential cofactor of mitochondrial enzyme complexes R( )- -lipoic acid inhibits NF- B-dependent HIV-1 LTR activation
Medchemexpress LLC Lipoic acid | 1200-22-2 | 968259 | 99.9% | 206.33 | 5 G
Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant and an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.
- Antioxidant
- Essential cofactor of mitochondrial enzyme complexes
- More effective than racemic lipoic acid
- Biosynthesized in humans and essential for aerobic metabolism
- Nutritionally and therapeutically preferred form due to its "vitamin-like" role in metabolism
- Exists in nature
Medchemexpress LLC Lipoic acid (standard) | 1200-22-2 | 99.83% | 206.33 | 50 MG
Lipoic acid (Standard) is the analytical standard of Lipoic acid, intended for research and analytical applications. Lipoic acid is an antioxidant and an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.
- Used as a reference standard supplied assay
- Commonly utilized in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
Medchemexpress LLC Lipoic acid impurity 1 | 18891-13-9 | 50mg
Lipoic acid impurity 1 is an impurity of Lipoic acid (HY-18733)
Medchemexpress LLC 1,2-Dithiolane-3-pentanoic acid, 2,5-dioxo-1-pyrrolidinyl ester | 40846-94-4 | 98.0% | C12H17NO4S2 | 1 G
α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are designed to selectively degrade target proteins by exploiting the intracellular ubiquitin-proteasome system. They achieve this by connecting two ligands with a linker: one targeting an E3 ubiquitin ligase and the other binding to the protein of interest. This product is for research use only.
- Alkyl/ether-based linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
eMolecules Ambeed / 46-Dimethylisophthalic acid / 100mg / 628568033 / A936930 / / 2790-09-2 / MFCD00230851 / 194.186 / C10H10O4
Ambeed / 46-Dimethylisophthalic acid / 100mg / 628568033 / A936930 / / 2790-09-2 / MFCD00230851 / 194.186 / C10H10O4
Selleck Chemical LLC Anethole trithione S4744-25mg
Anethole trithione is a drug used in the treatment of dry mouth
Medchemexpress LLC Lipoic acid impurity 1 | 18891-13-9 | 100mg
Lipoic acid impurity 1 is an impurity of Lipoic acid (HY-18733)
Medchemexpress LLC 4-Hydroxyisophthalic acid | 636-46-4 | 99.5% | C8H6O5 | 25 MG
4-Hydroxyisophthalic acid activates antioxidant enzymes, such as catalase (CAT) and superoxide dismutase (SOD), scavenges free radicals, and exhibits antioxidant property. It also activates AChE and BChE, enhancing neuronal function and improving Tau-induced neurobehavioral defects. Additionally, it improves cognitive defects and ameliorates circadian rhythm disorders in fruit flies.
- Activates antioxidant enzymes (CAT and SOD)
- Scavenges free radicals
- Exhibits antioxidant properties
- Enhances neuronal function
- Improves Tau-induced neurobehavioral defects
- Ameliorates circadian rhythm disorders
- Molecular weight: 182.13
- Appearance: Solid
- Color: Off-white to pink
- Structure classification: Ketones, aldehydes, acids
- Derived from plants Apocynaceae Decalepis hamiltonii Wight & Arn.
- For research use only