Dithiolanes
Selleck Chemical LLC MRT-2359-E1427-25MG
MRT-2359 is a potent degrader of GSPT1 It exhibits anti-tumor activity in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells
Medchemexpress LLC 4-Hydroxyisophthalic acid | 636-46-4 | 99.5% | C8H6O5 | 10 MM 1 ML
This compound activates antioxidant enzymes (such as catalase and superoxide dismutase) and scavenges free radicals, demonstrating antioxidant properties. It also activates AChE and BChE, which enhances neuronal function and improves neurobehavioral defects. Additionally, it can ameliorate cognitive defects and circadian rhythm disorders.
- Activates antioxidant enzymes and scavenges free radicals.
- Exhibits antioxidant properties.
- Enhances neuronal function.
- Improves neurobehavioral defects.
- Ameliorates cognitive defects and circadian rhythm disorders.
Chem-Impex International, Inc. 5-Carboxyfluorescein | MFCD00036874 | 1G
5-Carboxyfluorescein, MFCD00036874, 1G
Medchemexpress LLC 4-Hydroxyisophthalic acid | 636-46-4 | 99.5% | C8H6O5 | 50 MG
4-Hydroxyisophthalic acid activates antioxidant enzymes (such as catalase CAT and superoxide dismutase SOD), scavenges free radicals, and exhibits antioxidant properties. It also activates AChE and BChE, enhances neuronal function, improves Tau-induced neurobehavioral defects, and ameliorates cognitive defects and circadian rhythm disorders in fruit flies.
- Activates antioxidant enzymes (catalase and superoxide dismutase)
- Scavenges free radicals
- Exhibits antioxidant properties
- Activates AChE and BChE
- Enhances neuronal function
- Improves Tau-induced neurobehavioral defects
- Ameliorates cognitive defects
- Ameliorates circadian rhythm disorders in fruit flies
Medchemexpress LLC 4-Hydroxyisophthalic acid | 636-46-4 | 99.51% | C8H6O5 | 100 MG
4-Hydroxyisophthalic acid is a compound known for its antioxidant properties. It functions by activating key antioxidant enzymes such as catalase (CAT) and superoxide dismutase (SOD), and by scavenging free radicals. This compound also enhances neuronal function through the activation of AChE and BChE, which can lead to improvements in neurobehavioral defects induced by Tau protein and can ameliorate circadian rhythm disorders.
- Activates antioxidant enzymes (catalase CAT and superoxide dismutase SOD)
- Scavenges free radicals
- Exhibits antioxidant properties
- Activates AChE and BChE
- Enhances neuronal function
- Improves Tau-induced neurobehavioral defects
- Ameliorates circadian rhythm disorders in fruit flies
Cayman Chemical R-a-LIpoIc AcId 1g
A cyclic disulfide antioxidant; acts as a cofactor in 2-oxo dehydrogenase complex reactions and is reduced to DHLA; decreases serum levels of MDA and increases the activity of SOD and T-AOC in a mouse model of D-galactose-induced accelerated senescence at 100 mg/kg per day; reduces the escape latency in the Morris water maze compared to both D-galactose and vehicle control groups and rescues decreases in neural progenitor cell proliferation in the hippocampal dentate gyrus at 100 mg/kg per day
Medchemexpress LLC MRT-2359 | 2803881-11-8 | C22H17F4N3O6 | 25 MG
MRT-2359 is a potent, orally active, and selective GSPT1 depressant (IC50: >30 nM and <300 nM) that specifically induces apoptosis dependent on protein translation. It exhibits significant anti-proliferative activity in various cancer cell lines, particularly MYC-driven cell lines like non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) with high N-Myc or L-Myc expression, making it suitable for cancer research.
- Potent, orally active, and selective GSPT1 depressant
- Specifically induces apoptosis dependent on protein translation
- Significant anti-proliferative activity in MYC-driven cancer cell lines
- Effective against non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC)
- Inhibits the growth of drug-resistant NSCLC and SCLC cells
- Reduces N-Myc protein expression and tumor size
- Active against prostate cancer
Chem-Impex International, Inc. 5-Aminoisophthalic acid hydrate | MFCD09037349 | 25G
5-Aminoisophthalic acid hydrate, MFCD09037349, 25G
Medchemexpress LLC α-Lipoic Acid | 1077-28-7 | MFCD00005474 | 206.33 | 5 G
α-Lipoic Acid (Thioctic acid) is an antioxidant and an essential cofactor of mitochondrial enzyme complexes. It inhibits NF-κB-dependent HIV-1 LTR activation and induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. It can also be used with CPUL1 to construct the self-assembled nanoaggregate CPUL1-LA NA, which demonstrates improved antitumor efficacy compared to CPUL1.
- Antioxidant
- Essential cofactor of mitochondrial enzyme complexes
- Inhibits NF-κB-dependent HIV-1 LTR activation
- Induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells
- Can be used to construct self-assembled nanoaggregates with improved antitumor efficacy
Medchemexpress LLC Alpha-lipoic acid choline ester chloride | 1808266-58-1 | 99.7% | 327.93 | C13H26ClNO2S2 | 5 MG
Alpha-lipoic acid choline ester chloride is a choline ester derivative of alpha-lipoic acid provided for laboratory research. It can reduce protein disulfides and has been studied for improving lens elasticity and other presbyopia-related effects. The compound is supplied as a solid and as prepared DMSO solutions; store sealed at 4°C and handle per standard laboratory safety procedures.
- Choline ester derivative of alpha-lipoic acid
- Reduces protein disulfides
- Enhances lens elasticity in preclinical studies
- Available as solid and 10 mM DMSO solutions
- High purity (99.7%)
- Molecular formula C13H26ClNO2S2; molecular weight 327.93
Sigma Aldrich Fine Chemicals Biosciences Alpha Lipoic Acid1G
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
