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Navitoclax-piperazine (ABT-263-piperazine) is an analog of Navitoclax and acts as a BCL-XL inhibitor. It serves as the ligand for the target protein of PROTAC DT2216. This compound, when combined with an E3 ubiquitin ligase VHL ligand, can be used to synthesize PROTAC DT2216. PROTACs are compounds that leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Analog of Navitoclax
Acts as a BCL-XL inhibitor
Serves as a ligand for target proteins
Can be used in the synthesis of PROTACs
Utilizes the ubiquitin-proteasome system for selective protein degradation
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