Imidazopyridines
Medchemexpress LLC Bi-1622 | 2681392-19-6 | 99.0% | 508.53 g/mol | C26H24N10O2 | 10 MG
BI-1622 is an orally active, potent, and highly selective inhibitor of the HER2 (ERBB2) kinase, developed for preclinical research. It has reported biochemical potency (IC50) of 7 nM, shows greater than 25-fold selectivity over EGFR, and has demonstrated efficacy in HER2-driven xenograft models.
Medchemexpress LLC HY-100412 5mg Medchemexpress, Linaprazan CAS:248919-64-4 Purity:>98%
Medchemexpress, HY-100412 5mg Linaprazan CAS:248919-64-4 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC (E)-5-((8-methoxy-2-methylquinolin-4-yl)amino)-N'-(4-(methylthio)benzylidene)-1H-indole-2-carbohydr | 2469975-55-9 | MFCD34167507 | 98.6% | 495.60 g/mol | C28H25N5O2S | 5 MG
Nur77 modulator 1 is a small-molecule ligand that binds the nuclear receptor Nur77 (KD = 3.58 μM). It up-regulates Nur77 expression, alters subcellular localization, induces Nur77-dependent endoplasmic reticulum stress and autophagy, and can lead to apoptosis; reported anti-hepatoma activity. For research use only.
- Binds Nur77 with a KD of 3.58 μM.
- Up-regulates Nur77 expression and alters subcellular localization.
- Induces ER stress and autophagy, leading to apoptosis.
- Reported anti-hepatoma activity in preclinical studies.
- High purity solid suitable for in vitro assays; soluble in DMSO.
- Available in multiple pack sizes for research workflows.
eMolecules AstaTech / OLPRINONE HYDROCHLORIDE HYDRATE / 0.25g / 721754863 / E85868 / 95.000 / 2072803-95-1 / MFCD00946577 / 304.730 / C14H13ClN4O2
AstaTech / OLPRINONE HYDROCHLORIDE HYDRATE / 0.25g / 721754863 / E85868 / 95.000 / 2072803-95-1 / MFCD00946577 / 304.730 / C14H13ClN4O2
Medchemexpress LLC PDE2A-IN-3 | 1426833-08-0 | 295.73 | 50 MG
PDE2A-IN-3 (Example Ic1) is a selective phosphodiesterase 2A (PDE2A) inhibitor with IC50s of 69 nM and 1762 nM for PDE2A and PDE10, respectively. It can be used for the study of neurological and psychiatric disorders.
- Selective phosphodiesterase 2A (PDE2A) inhibitor
- IC50 of 69 nM for PDE2A and 1762 nM for PDE10
- Useful for research into neurological and psychiatric disorders
![Medchemexpress LLC 4-Oxazolecarboxamide, N-[6-[(2-methoxyethyl)methylamino]-3-pyridinyl]-2-phenyl-5-(trifluoromethyl)- | 939375-07-2 | 99.9% | 420.39 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000394191.png-250.jpg)
Medchemexpress LLC 4-Oxazolecarboxamide, N-[6-[(2-methoxyethyl)methylamino]-3-pyridinyl]-2-phenyl-5-(trifluoromethyl)- | 939375-07-2 | 99.9% | 420.39 | 5 MG
DGAT1-IN-3 is a potent, selective, and orally bioavailable inhibitor of DGAT-1, with IC50s of 38 nM for human DGAT-1 and 120 nM for rat DGAT-1. It can be used for research on obesity, dyslipidemia, and metabolic syndrome.
- Potent, selective, and orally bioavailable inhibitor of DGAT-1.
- IC50s: 38 nM (human DGAT-1); 120 nM (rat DGAT-1).
- Reduces weight gain and plasma triglycerides, and improves lipid profile in animal models.
- Exhibits good oral bioavailability (77%) and a maximum exposure level in plasma (Cmax) of 24 μM (50 mg/kg; p.o).
- Exhibits terminal elimination half-lives (1.95 h) and low clearance (13.5 mL/min/kg) (5 mg/kg; i.v).
- Appearance: solid, light yellow to yellow color.
Medchemexpress LLC DGAT1-IN-3 | 939375-07-2 | 99.9% | 420.39 | 50 MG
DGAT1-IN-3 is a potent, selective and orally bioavailable inhibitor of DGAT-1, with IC50s of 38 nM for human DGAT-1 and 120 nM for rat DGAT-1. It could be used to research of obesity, dyslipidemia, and metabolic syndrome.
- IC50 of 38 nM for human DGAT-1; 120 nM for rat DGAT-1
- Inhibits human DGAT1 expressed in CHOK1 cells with an EC50 of 0.66 μM
- Blocks the human ether-a-go-go-related gene (hERG) encoded potassium channel with an IC20 of 0.2 μM
- Reduces weight gain and plasma triglycerides, and improves lipid profile (5-50 mg/kg; p.o once daily for three weeks)
- Exhibits good oral bioavailability (77%) and a maximum exposure level in plasma (Cmax) of 24 μM (50 mg/kg; p.o)
- Exhibits terminal elimination half-lives (1.95 h) and low clearance (13.5 mL/min/kg) (5 mg/kg; i.v)
eMolecules Olprinone | 106730-54-5 | MFCD25541649 | 1g
Combi-Blocks | Olprinone | 1g | 457920662 | QV-9982 | 97.000 | 106730-54-5 | MFCD25541649 | 250.261 | C14H10N4O
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![eMolecules (6-Chloro-imidazo[1,2-a]pyridin-2-ylmethyl)-methyl-amine | 554407-29-3 | MFCD03970805 | 5g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502156169.JPG-250.jpg)
eMolecules (6-Chloro-imidazo[1,2-a]pyridin-2-ylmethyl)-methyl-amine | 554407-29-3 | MFCD03970805 | 5g
J & W PharmLab LLC | (6-Chloro-imidazo[1,2-a]pyridin-2-ylmethyl)-methyl-amine | 5g | 289354608 | 68R0212 | 96.000 | 554407-29-3 | MFCD03970805 | 195.650 | C9H10ClN3
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