Lactams
Medchemexpress LLC Thalidomide-5-PEG2-Cl | 2230956-57-5 | 96.6% | 380.78 | 50 MG
Thalidomide-5-PEG2-Cl is a thalidomide-based cereblon ligand designed for the recruitment of CRBN protein. It can be linked to other ligands via a linker to form PROTACs, which exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- Connects to ligands for protein by a linker to form PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide-5-O-C4-NH2 hydrochloride | 2694727-93-8 | 100.0% | 381.81 g/mol | C17H20ClN3O5 | 10 MG
Thalidomide-5-O-C4-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand intended for chemical biology research and PROTAC design. Supplied as a white to off-white solid in small milligram quantities, the compound functions as an E3 ligase recruiting moiety that can be connected to target ligands via linkers for targeted protein degradation studies.
- High purity suitable for research applications (reported ~99.98%).
- Acts as a cereblon-binding ligand for E3 ligase recruitment.
- Designed for PROTAC synthesis and linker conjugation.
- Available in small milligram pack sizes for screening and synthesis.
- Solid form, white to off-white, stable under recommended storage.
- Includes CAS number 2694727-93-8 for unambiguous identification.
Abcam (R,S)-Lenalidomide, Thalidomide analog, TNF alpha inhibitor, 100MG
MW 259.26 Da, Purity >98%. Thalidomide (ab120032) analog and TNF-α inhibitor. Potent antitumor and anti-inflammatory effects. Modulates and potentiates host immune responses against multiple myeloma. Active in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Thalidomide-NH-C4-NH-Boc | 2093388-52-2 | 99.6% | 100 MG
Thalidomide-NH-C4-NH-Boc (compound 15) is a synthesized E3 ligase ligand-linker conjugate that incorporates a Thalidomide-based cereblon ligand and a linker utilized in PROTAC technology. It is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate.
- Incorporates Thalidomide based cereblon ligand.
- Uses a linker in PROTAC technology.
- High purity of 99.64%.
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 100 MG
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. This product is for research use only and not intended for sale to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Utilizes linker used in PROTAC technology
- For research use only
Medchemexpress LLC Thalidomide-O-C6-COOH | 2169266-69-5 | 99.3% | 1 ML
Thalidomide-O-C6-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a thalidomide-based cereblon ligand and a linker used in PROTAC technology. This product targets cereblon.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Designed for PROTAC technology
- Targets cereblon
- Appearance: off-white to light yellow solid
- Solubility: ≥ 100 mg/mL in DMSO
Medchemexpress LLC Thalidomide-nh-c6-nh-boc | 2093536-13-9 | 96.1% | 100 MG
Thalidomide-NH-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used for MI-389 (compound 22) synthesis. MI-389 is a potent phthalimide PROTAC degrader based on the multi-targeted receptor tyrosine kinase inhibitor sunitinib (HY-10255A).
- Decreases cell growth with an EC50 value of 21.3 nM (comparable to sunitinib)
- Leads to GSPT1 destabilization in a dose-dependent manner, showing complete GSPT1 depletion at 100 nM.
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | 95.1% | 1 ML
Thalidomide-O-C8-Boc is a Thalidomide-based Cereblon ligand utilized for the recruitment of CRBN protein. It can be linked to a target protein ligand via a linker to create PROTACs.
- Cereblon ligand
- Used for recruitment of CRBN protein
- Can be linked to a target protein ligand via a linker to create PROTACs
- For research use only
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 50 MG
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a Thalidomide-based cereblon ligand
- Uses a linker in PROTAC technology
- Targets Cereblon
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-iodo | 2509137-01-1 | MFCD31735039 | 98.0% | 384.13 | C13H9IN2O4 | 100 MG
Thalidomide-iodo is an iodinated derivative of thalidomide supplied as a research reagent. It acts as an E3 ligase activator and is suitable as a synthetic building block for further derivatization via substitution of the iodine. Typical specifications include CAS 2509137-01-1, molecular formula C13H9IN2O4, molecular weight 384.13, and reported purity of 98.0%.
- Iodinated E3 ligase activator for probe and degrader research.
- Synthetic building block amenable to substitution of iodine.
- High purity suitable for analytical and synthetic workflows.
- Available in multiple pack sizes for small-scale research.
- Intended for laboratory research use only.
Medchemexpress LLC Thalidomide-4-O-C4-NH2 hydrochloride | 2376990-29-1 | MFCD32705123 | 99.4% | C17H20ClN3O5 | 10MG
Thalidomide-4-O-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon-binding moiety with a C4 amine-containing linker for use in PROTAC development and targeted protein degradation research. Supplied as a hydrochloride salt and intended for research use only.
- Hydrochloride salt form for improved handling and solubility.
- High purity suitable for biochemical and cell-based assays.
- Molecular formula C17H20ClN3O5; molecular weight 381.81 g·mol⁻¹.
- Available in small milligram quantities for discovery research.
- Storage: sealed at 4°C; in solution, -80°C for long-term storage.
Sigma Aldrich Fine Chemicals Biosciences Strychnine | 57-24-9 | MFCD00005941 | 5G
Strychnine | Mol Wt: 334.41 | 57-24-9 | MFCD00005941 | 5G
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | 95.1% | 50 MG
Thalidomide-O-C8-Boc is a thalidomide-based cereblon ligand that is used to recruit the CRBN protein. It can be linked to a protein ligand by a linker to create PROTACs. This product is intended for research use only.
- Functions as a thalidomide-based cereblon ligand
- Utilized for recruitment of CRBN protein
- Connects to protein ligands via a linker to form PROTACs
- Targets cereblon
Medchemexpress LLC Thalidomide-C2-amido-C2-COOH | 2353496-84-9 | 98.5% | 25 MG
Thalidomide-C2-amido-C2-COOH incorporates a CRBN ligand for the E3 ubiquitin ligase and a linker. This compound is suitable for designing PROTAC CDK2/9 Degrader-1.
- Incorporates a CRBN ligand for the E3 ubiquitin ligase and a linker
- Targets cereblon
- Has a molecular weight of 416.38
- Has a molecular formula of C19H20N4O7
- Appears as a solid with a light yellow to yellow color
- Purity of 98.45%
- Soluble in DMSO at 100 mg/mL (requires ultrasonic)
- Powder storage: -20°C for 3 years
- In-solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 250 MG
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. This product is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Used in PROTAC technology
- Purity of 99.8%
- CAS number: 2093386-51-5
- Molecular weight: 486.44
- Chemical formula: C21H25F3N4O6
- Appearance as a solid
- Color ranges from light yellow to yellow
- Targets cereblon