Lactams
Apexbio Technology LLC Thalidomide 50-35-1 10mM (in 1mL DMSO)
Thalidomide (CAS 50-35-1) is a small-molecule inhibitor targeting the CRBN-DDB1-Cul4A E3 ubiquitin ligase complex It is designed to modulate ubiquitination pathways thereby regulating protein degradation cellular proliferation and immune signaling Thalidomide exerts its biological activity primarily through inhibition of the CRBN-DDB1-Cul4A complex In cell-based studies thalidomide demonstrates inhibitory activity with reported IC50 values ranging from approximately 1 M to 100 M depending on the assay and cell line Based on these pharmacological properties thalidomide holds research potential in the fields of immune regulation angiogenesis inhibition and cancer biology particularly in studies of hematological malignancies such as multiple myeloma
Medchemexpress LLC Thalidomide-5-O-C13-NH2 hydrochloride | 99.9% | 508.05 g/mol | C26H38ClN3O5 | 10 MG
Thalidomide-5-O-C13-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for research use in targeted protein degradation. It is intended for conjugation to target-binding ligands via linkers for PROTAC design and other bifunctional degrader constructs.
- High purity suitable for research assays (approximately 99.9%).
- Hydrochloride salt form for improved stability and handling.
- Compatible with linker conjugation for PROTAC synthesis.
- Recommended storage at -20°C; protect from light and oxygen.
- Supplied in small milligram quantities for exploratory studies.
Medchemexpress LLC CD3 epsilon Canine 100ug | 100ug
The CD3 protein on lymphocytes is a component of the TCR-CD3 complex and is critical for adaptive immune responses When APC is activated TCR signals transmitted by CD3D CD3E CD3G and CD3Z initiate pathways through ITAM CD3 epsilon Protein Canine (HEK293 Fc) is the recombinant canine-derived CD3 epsilon protein expressed by HEK293 with C-hFc labeled tag
Medchemexpress LLC 14-3-3 epsilon protein (human), GST-tagged | >95.0% | 5 UG
Recombinant human 14-3-3 epsilon protein fused to an N-terminal GST tag, expressed in Escherichia coli and supplied at high purity for research use. It is suitable for immunoassays, binding studies, and functional assays investigating 14-3-3-mediated signaling and inflammatory responses.
- Source species: human.
- Expression system: Escherichia coli.
- Tag: N-terminal GST.
- Purity: >95.0% by reducing SDS-PAGE.
- Molecular weight: approximately 55.0-58.0 kDa.
- Available size: 5 μg, suitable for assay use.
- Storage: store at -20 °C; after reconstitution stable at 4 °C for 1 week; aliquot and freeze at -80 °C for long term.
- Reported activity: ED50 = 0.3162 μg/mL in antibody-binding assay.
Medchemexpress LLC Epsilon-momfluorothrin | 1065124-65-3 | 99.8% | 385.35 | 1 ML
Epsilon-momfluorothrin is a type I synthetic pyrethroid insecticide that activates the constitutive androstane receptor (CAR) and induces hepatocellular tumors in rats. It is for research use only and not sold to patients.
- Type I synthetic pyrethroid insecticide
- Activates constitutive androstane receptor (CAR)
- Induces hepatocellular tumors in rats
