Lactams
Medchemexpress LLC Vh 101 phenol-alkylc6-amine dihydrochloride | 2564467-16-7 | 704.72 | 50 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand. This compound is suitable for PROTAC synthesis.
- Functionalized von-Hippel-Lindau (VHL) protein-ligand
- Can be used for PROTAC synthesis
Medchemexpress LLC Thalidomide-o-amido-c4-n3 | 2098488-36-7 | 98.4% | 428.40 | C19H20N6O6 | 25 MG
Thalidomide-O-amido-C4-N3 is a thalidomide-derived cereblon ligand-linker conjugate containing an azide functional group. It is used as a building block in PROTAC design and as a click-chemistry reagent to attach CRBN ligands to alkyne-bearing partners, enabling targeted protein degradation applications.
- Azide functional group compatible with CuAAC and SPAAC click chemistry.
- Designed as a cereblon (CRBN) ligand-linker conjugate for PROTAC synthesis.
- High purity as supplied (LCMS ~98.4%).
- Soluble in DMSO (≥ 41 mg/mL) for in vitro formulation.
- In vivo formulation examples achieve ≥ 2.5 mg/mL in common solvents and vehicles.
- Store under inert atmosphere at 4°C; in solution store at -80°C for long-term stability.
Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.9 % | 276.22 | 50 G
Thalidomide 4-fluoride is a Thalidomide-based Cereblon ligand designed for the recruitment of CRBN protein. It can be linked to other ligands by a linker to form PROTAC degraders. In vitro, Thalidomide targets cereblon (CRBN), a ubiquitously expressed protein that is part of the cullin-4 E3 ubiquitin ligase complex. Cereblon mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
- Thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to other ligands to form PROTAC degraders
- Targets cereblon (CRBN), a protein involved in the cullin-4 E3 ubiquitin ligase complex
- Mediates ubiquitination and proteasomal degradation of target proteins
- High purity for reliable research
- Solid appearance, off-white to gray color
- Stable under recommended storage conditions
- Soluble in DMSO (200 mg/mL)
Medchemexpress LLC Thalidomide-5-COOH | 1216805-11-6 | 99.9% | 302.24 | 500 MG
Thalidomide-5-COOH is a Thalidomide-based cereblon ligand utilized for the recruitment of CRBN protein. It can be linked to a protein ligand via a linker to form PROTACs.
- Utilized for the recruitment of CRBN protein
- Can be linked to a protein ligand via a linker
- Forms PROTACs
- PROTACs use the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC N-Me-thalidomide 4-fluoride | 2244520-92-9 | MFCD34563580 | 99.4% | 290.25 g/mol | C14H11FN2O4 | 1 G
N-Me-Thalidomide 4-fluoride is a research-grade small molecule ligand for E3 ligase used in chemical biology and PROTAC development. It functions as a building block in the synthesis of targeted degraders and related small-molecule tools. Supplied for laboratory research use only.
- Ligand for E3 ligase.
- Useful building block for synthesis of targeted degraders and anti-inflammatory agents.
- High reported purity (99.41%).
- Molecular formula C14H11FN2O4; molecular weight 290.25 g/mol.
- Available in research pack sizes suitable for small-scale synthesis.
Medchemexpress LLC Thalidomide-Piperazine-PEG2-NH2 (diTFA) | 99.7% | 701.57 | 25 MG
Thalidomide-Piperazine-PEG2-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker used in PROTAC technology. It is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Includes a linker used in PROTAC technology
- Targets Cereblon
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide 4-fluoride (Cereblon ligand 4) | 835616-60-9 | 99.83% | 276.22 | 25 G
Thalidomide 4-fluoride (Cereblon ligand 4) is a Thalidomide-based Cereblon ligand that is utilized in the recruitment of the CRBN protein. It can be linked to the ligand for IRAK4 protein via a linker to form PROTAC IRAK4 degrader-1. It is for research use only and not sold to patients.
- Purity: 99.83%
- Molecular weight: 276.22
- Formula: C13H9FN2O4
- CAS No.: 835616-60-9
- Appearance: Solid
- Color: Off-white to gray
- Solubility (in vitro): DMSO : 200 mg/mL (724.05 mM; requires ultrasonic; hygroscopic DMSO impacts solubility, use newly opened DMSO)
- Storage (powder): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 2 years, -20°C for 1 year
Medchemexpress LLC Thalidomide-5-OH | 64567-60-8 | 98.2% | 274.23 | 25 G
Thalidomide-5-OH is a thalidomide-based cereblon ligand. It is used in the recruitment of CRBN protein and can be connected to a target protein ligand via a linker to form PROTACs.
- Thalidomide-based cereblon ligand
- Recruits CRBN protein
- Connects to protein ligands via a linker to form PROTACs
- Targets cereblon
Medchemexpress LLC Thalidomide-O-C4-COOH | 2169266-67-3 | 97.0% | 250 MG
Thalidomide-O-C4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates Thalidomide based cereblon ligand
- Used in PROTAC technology
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 250 MG
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. This product is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Used in PROTAC technology
- Purity of 99.8%
- CAS number: 2093386-51-5
- Molecular weight: 486.44
- Chemical formula: C21H25F3N4O6
- Appearance as a solid
- Color ranges from light yellow to yellow
- Targets cereblon
Medchemexpress LLC VH 101 phenol-alkylC4-amine dihydrochloride | 2564467-03-2 | 676.67 | 25 MG
VH 101 phenol-alkylC4-amine dihydrochloride is a von-Hippel-Lindau protein ligand (VHL). It incorporates an E3 ligase ligand and an alkylC4 linker.
- Von-Hippel-Lindau protein ligand (VHL)
- Incorporates an E3 ligase ligand
- Incorporates an alkylC4 linker
- Can be used for PROTAC research (extracted from patent WO2022051326A1)
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | 97.0% | 384.19 g/mol | C19H21BN2O6 | 50 MG
Thalidomide-pinacolborane is a thalidomide analogue containing a pinacol boronate (Bpin) group, supplied as a research reagent for use in synthetic chemistry and chemical biology. It is suitable as a building block for cross-coupling reactions and as a probe to investigate E3 ligase-mediated ubiquitination in degradation studies.
- Contains a pinacol boronate functional group for cross-coupling chemistry.
- Useful as a synthetic intermediate in Suzuki-Miyaura reactions.
- Acts as a thalidomide analogue for studying E3 ligase activity.
- Supplied as a high-purity research chemical suitable for analytical and preparative use.
- Provided in small-quantity packaging for laboratory experiments.
Medchemexpress LLC Thalidomide-O-C2-acid | 2369068-42-6 | 95.0% | C16H14N2O7 | 10MG
Thalidomide-O-C2-acid is an E3 ligase ligand-linker conjugate that pairs a thalidomide-derived cereblon ligand with a two-carbon linker. It is designed as a research building block for proteolysis targeting chimera (PROTAC) construction and targeted protein degradation studies, and is supplied with analytical data supporting its identity and purity.
- Contains a thalidomide-derived cereblon ligand for CRBN recruitment.
- Includes a short two-carbon linker suitable for conjugation.
- Provided with reported purity and molecular characterization.
- Available in multiple small pack sizes for research-scale synthesis.
- Intended for use as a building block in PROTAC synthesis and chemical biology studies.
- Supplied with an accessible datasheet and safety documentation.
Cayman Chemical ThalIdomIde 25mg
An active enantiomer of (±)-thalidomide; enhances TPA-induced TNF-α production in HL-60 cells from 0.1-100 µM; preincubation of isolated RIR chicken donor blood reduces recipient chicken embryo splenomegaly in a model of graft versus host disease at 10 mg/ml; induces fetal malformations when administered to pregnant female rabbits at 150 mg/kg
Medchemexpress LLC N-Me-Thalidomide 4-fluoride | 2244520-92-9 | MFCD34563580 | 99.4% | 290.25 g/mol | C14H11FN2O4 | 500 MG
N-Me-Thalidomide 4-fluoride is a thalidomide-derived ligand for E3 ligase (Cereblon) used as a building block in targeted protein degradation chemistry and small-molecule conjugation. It is supplied as a research-grade small molecule with characterization data for medicinal chemistry and chemical biology applications.
- Ligand for E3 ligase (Cereblon) for PROTAC synthesis.
- High reported purity suitable for research use.
- Molecular formula C14H11FN2O4 and molecular weight 290.25 g/mol.
- Available in multiple pack sizes, including 250 MG, 500 MG, and 1 G.
- Supplied with associated safety and batch documentation.