Lactams
Medchemexpress LLC Thalidomide-piperazine 5-fluoride hydrochloride | 2222114-23-8 | MFCD32203462 | 98.9% | 396.80 g/mol | C17H18ClFN4O4 | 1 G
Thalidomide-piperazine 5-fluoride hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as a hydrochloride salt for use in PROTAC synthesis and related cereblon-targeted chemical biology research. It is intended for research use and is provided with documented purity and stability data for handling and storage.
- Thalidomide-based cereblon ligand for PROTAC synthesis.
- Hydrochloride salt form for improved handling and solubility.
- High purity suitable for synthetic and analytical workflows.
- Documented stability under cold storage conditions.
- Provided in a small-scale research package for medicinal chemistry.
Medchemexpress LLC Thalidomide-5-O-C6-NH2 hydrochloride | 2761398-05-2 | 409.86 | C19H24ClN3O5 | 10 MG
Thalidomide-5-O-C6-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand used as an E3 ligase recruiting moiety in PROTAC development and chemical biology research. The compound contains a six-carbon linker terminating in a primary amine and is supplied as the hydrochloride salt to aid handling and stability for research applications.
- Used as a cereblon ligand to recruit CRBN in PROTAC and degrader design.
- Contains a C6 linker with a terminal amine for conjugation to linkers or target ligands.
- Provided as a hydrochloride salt for improved handling and solubility.
- Solid form suitable for storage under recommended conditions.
- Intended for research use; consult vendor documentation or COA for purity and analytical data.
Medchemexpress LLC Thalidomide-5-O-C11-NH2 hydrochloride | >98.0% | 480.00 | C24H34ClN3O5 | 10 MG
Thalidomide-5-O-C11-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand used to recruit the CRBN E3 ligase in targeted protein degradation constructs. Supplied as a white to off-white solid, it is intended for research use in PROTAC synthesis and ligand-linker conjugation. Handle under light protection and low-temperature storage to maintain stability.
- Thalidomide-derived cereblon ligand for E3 ligase recruitment.
- High purity (>98.0% HPLC) suitable for synthetic applications.
- White to off-white solid, convenient for handling and weighing.
- Stable under low-temperature, light-protected storage when handled under nitrogen.
- Available in small research quantities for conjugation and PROTAC development.
Medchemexpress LLC Thalidomide-5-O-C10-NH2 hydrochloride | 99.4% | 465.97 g/mol | C23H32ClN3O5 | 10 MG
Thalidomide-5-O-C10-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for chemical biology research. It is used to recruit the CRBN E3 ubiquitin ligase in PROTAC and conjugate applications to enable targeted protein ubiquitination and degradation. Molecular formula C23H32ClN3O5; molecular weight 465.97 g/mol.
- Used as a cereblon-binding ligand for PROTAC and conjugate design.
- Supplied as the hydrochloride salt for improved handling and stability.
- High purity suitable for research applications.
- Available in small research pack sizes for synthesis and screening.
- Provides a chemical handle designed for linker attachment to target ligands.
eMolecules 17557-84-5 | 3-Azetidinone hydrochloride | Synthonix - Stock | MFCD01861742 | 107.540 | C3H6ClNO | 97.000 | Cl.O=C1CNC1 | 5g | 525905204
3-Azetidinone hydrochloride | Synthonix - Stock | 17557-84-5 | MFCD01861742 | 107.540 | C3H6ClNO | 97.000 | Cl.O=C1CNC1 | 5g | 525905204
Medchemexpress LLC S-thalidomide-4-OH | 2357105-36-1 | MFCD03699892 | 98.0% | 274.23 | C13H10N2O5 | 25 MG
(S)-Thalidomide-4-OH is the S-enantiomer of thalidomide-4-OH, a thalidomide-based cereblon (CRBN) ligand used in chemical biology and proteolysis-targeting chimera (PROTAC) design. Supplied as a high-purity powder, it is intended for research use in CRBN recruitment studies and degrader synthesis.
- High purity (98.0%) for research applications.
- S-enantiomer for stereospecific biochemical studies.
- Useful cereblon ligand for PROTAC conjugation.
- Available in small milligram quantities for screening and synthesis.
- Stable when stored under recommended conditions.
Medchemexpress LLC Thalidomide-5-PEG2-Cl | 2230956-57-5 | 96.6% | 380.78 | 250 MG
Thalidomide-5-PEG2-Cl is a Thalidomide-based cereblon ligand that plays a crucial role in recruiting CRBN protein. It can be utilized to form PROTACs by linking to a target protein ligand. PROTACs are designed to selectively degrade target proteins within the intracellular ubiquitin-proteasome system by exploiting E3 ubiquitin ligase and target protein interactions.
- Thalidomide-based cereblon ligand
- Recruits CRBN protein
- Can be linked to form PROTACs
- Exploits ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride | 2983037-00-7 | >98.0% | 586.03 | 25 MG
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It integrates a thalidomide-based cereblon ligand with a linker, making it suitable for applications in PROTAC technology. This compound is intended for research purposes only and is not for sale to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Utilizes a linker for PROTAC technology applications
- Suitable for research use
Medchemexpress LLC Thalidomide-Piperazine-PEG2-NH2 (diTFA) | 99.7% | 701.57 | 25 MG
Thalidomide-Piperazine-PEG2-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker used in PROTAC technology. It is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Includes a linker used in PROTAC technology
- Targets Cereblon
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide-1-me-5-nh2 | 1468761-60-5 | >98.0% | 287.27 g·mol-1 | C14H13N3O4 | 50 MG
Thalidomide-1-Me-5-NH2 is an aminated thalidomide analogue used as a cereblon E3 ligase ligand and building block for PROTAC design and related chemical biology research. It is intended for derivatization at the amine for linker attachment and is supplied as a high-purity research reagent suitable for synthetic applications.
- Aminated thalidomide analogue enabling linker derivatization
- Serves as a cereblon E3 ligase ligand for PROTAC design
- High purity for research applications (>98.0%)
- Supplied in small milligram-scale quantities suitable for synthesis (50 mg)
- Molecular formula C14H13N3O4, molecular weight 287.27 g·mol-1
- CAS number 1468761-60-5 for unambiguous identification
Medchemexpress LLC Thalidomide 10 mM * 1 mL in DMSO Solution
Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate.
Medchemexpress LLC Thalidomide-CH2NH2 hydrochloride | 444287-40-5 | 98.1% | 323.73 | 100 MG
Thalidomide-CH2NH2 hydrochloride is a Thalidomide analogue featuring a primary amine, a versatile functional group that can participate in various reactions. It is intended for research use only.
- Features a primary amine group
- Provided as a solid, white to off-white in color
- Ships at room temperature in continental US
- Powder storage at -20°C for 3 years, 4°C for 2 years
- Storage in solvent at -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.9% | 276.22 | 5 G
Thalidomide 4-fluoride is a Thalidomide-based Cereblon ligand that recruits CRBN protein and can be linked to the ligand for IRAK4 protein to create PROTAC IRAK4 degrader-1. This compound targets cereblon (CRBN), a ubiquitous protein involved in the cullin-4 E3 ubiquitin ligase complex CRL4, facilitating the ubiquitination and subsequent proteasomal degradation of target proteins.
- Recruits CRBN protein.
- Can be linked to IRAK4 protein ligand.
- Targets cereblon (CRBN).
- Facilitates ubiquitination and proteasomal degradation of target proteins.
- Molecular weight: 276.22.
- Physical state: solid.
- Color: off-white to gray.
- Soluble in DMSO.
- Store powder at -20°C for 3 years or 4°C for 2 years.
- Store in solvent at -80°C for 2 years or -20°C for 1 year.
- Avoid repeated freeze-thaw cycles after preparation into solution.
Medchemexpress LLC Thalidomide-5-COOH | 1216805-11-6 | 99.9% | 302.24 | 500 MG
Thalidomide-5-COOH is a Thalidomide-based cereblon ligand utilized for the recruitment of CRBN protein. It can be linked to a protein ligand via a linker to form PROTACs.
- Utilized for the recruitment of CRBN protein
- Can be linked to a protein ligand via a linker
- Forms PROTACs
- PROTACs use the intracellular ubiquitin-proteasome system to selectively degrade target proteins