Lactams
Medchemexpress LLC Thalidomide-O-C6-azide | 2411389-65-4 | 99.1% | 399.40 | 50 MG
Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates a thalidomide-based cereblon ligand and a linker used in PROTAC technology. This product is also a click chemistry reagent, containing an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a thalidomide-based cereblon ligand
- Features a linker used in PROTAC technology
- Functions as a click chemistry reagent with an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Allows strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Supports selective degradation of target proteins through PROTACs
Cayman Chemical AzIdo-ThalIdomIde 10mg
A PROTAC building block; contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry; has been used in the synthesis of a SirReal-based PROTAC for the degradation of Sirt2 in cells
Medchemexpress LLC Thalidomide-5-O-C9-NH2 hydrochloride | 451.94 | 5 MG
Thalidomide-5-O-C9-NH2 hydrochloride is a chemical compound primarily used as a laboratory chemical for research purposes and substance manufacturing. It is presented as a solid and is stable under recommended storage conditions.
- Solid appearance
- Stable under recommended storage conditions
- For research use only
Medchemexpress LLC Thalidomide-NH-PEG4-COOH | 2412056-48-3 | 96.7% | 521.52 | 50 MG
Thalidomide-NH-PEG4-COOH is an E3 ligase ligand-linker conjugate which can be used for synthesizing dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP.
- E3 ligase ligand-linker conjugate
- Used for synthesizing dCBP-1
- Potent and selective heterobifunctional degrader of p300/CBP
- Purity of 96.7%
- Appearance: yellow to green (solid-liquid mixture)
- Store at -20°C, protect from light
Medchemexpress LLC Thalidomide-O-amido-C4-NH2 trifluoroacetate | 1799711-25-3 | MFCD31560484 | 99.9% | 516.42 g/mol | C21H23F3N4O8 | 500 MG
Thalidomide-O-amido-C4-NH2 (TFA) is a thalidomide-derived cereblon ligand-linker conjugate supplied as the trifluoroacetate salt for use in PROTAC and degrader research. The material is provided as a white to off-white solid with documented purity, solubility, and storage recommendations to support formulation and biological testing.
- Thalidomide-based cereblon ligand-linker conjugate (TFA salt)
- High purity: 99.92% (LCMS)
- Molecular weight 516.42 g/mol; formula C21H23F3N4O8
- Solubility: DMSO 42.86 mg/mL; established in vivo vehicle protocols at ≥2.5 mg/mL
- Storage: solid at 4°C under nitrogen; in solution -80°C (up to 6 months) or -20°C (up to 1 month)
- Intended for use in synthesis and biological evaluation of PROTACs and E3 ligase degrader studies
Medchemexpress LLC Thalidomide-NH-PEG3-propionic acid | 2138440-82-9 | 99.72% | 477.46 | 25 MG
Thalidomide-NH-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate used in PROTAC technology. It incorporates a thalidomide-based cereblon ligand and a 3-unit PEG linker.
- PROTACs contain two different ligands connected by a linker.
- One ligand is for an E3 ubiquitin ligase and the other is for the target protein.
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Stable under recommended storage conditions.
- Recommended storage temperature: 4°C, protect from light.
Medchemexpress LLC Thalidomide-5-O-C2-NH2 hydrochloride | 2694727-89-2 | 98.0% | 353.76 g/mol | C15H16ClN3O5 | 10 MG
Thalidomide-5-O-C2-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt. It is used as an E3 ligase ligand-linker conjugate in targeted protein degradation research and PROTAC synthesis, enabling the attachment of linkers or functional groups to the thalidomide scaffold for chemical biology applications.
- High reported purity, 98.0%.
- Supplied as the hydrochloride salt for improved handling.
- Functions as a cereblon (CRBN) ligand for E3 ligase recruitment.
- Suitable for PROTAC synthesis and ligand-linker conjugation.
- Characterized by CAS 2694727-89-2 and molecular weight 353.76 g/mol.
- Available in small research pack sizes such as 10 MG.
![Medchemexpress LLC Cyclopropyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f]triazolo[4,3-a]diazepin-6-yl) | 3077900-08-1 | 98.3% | 440.95 | C22H21ClN4O2S | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000294895.png-250.jpg)
Medchemexpress LLC Cyclopropyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f]triazolo[4,3-a]diazepin-6-yl) | 3077900-08-1 | 98.3% | 440.95 | C22H21ClN4O2S | 10 MG
DDL-357 is a small-molecule secreted clusterin (sCLU) enhancer used as a research probe to increase sCLU levels in brain, reduce pathological phospho-tau, and improve memory in Alzheimer's disease mouse models. It is supplied as a 10 mg research sample intended for preclinical and in vitro studies.
- Potent secreted clusterin enhancer that increases sCLU in brain.
- Reduces phospho-tau and improves cognitive performance in murine 3xTg-AD models.
- Suitable for preclinical in vivo and in vitro research applications.
- Provided as a 10 mg research sample with 98.3% purity.
- Molecular weight 440.95; molecular formula C22H21ClN4O2S; CAS 3077900-08-1.
Medchemexpress LLC Thalidomide-NH-C4-NH-Boc | 2093388-52-2 | 99.6% | 100 MG
Thalidomide-NH-C4-NH-Boc (compound 15) is a synthesized E3 ligase ligand-linker conjugate that incorporates a Thalidomide-based cereblon ligand and a linker utilized in PROTAC technology. It is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate.
- Incorporates Thalidomide based cereblon ligand.
- Uses a linker in PROTAC technology.
- High purity of 99.64%.
Medchemexpress LLC Thalidomide-nh-c6-nh-boc | 2093536-13-9 | 96.1% | 100 MG
Thalidomide-NH-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used for MI-389 (compound 22) synthesis. MI-389 is a potent phthalimide PROTAC degrader based on the multi-targeted receptor tyrosine kinase inhibitor sunitinib (HY-10255A).
- Decreases cell growth with an EC50 value of 21.3 nM (comparable to sunitinib)
- Leads to GSPT1 destabilization in a dose-dependent manner, showing complete GSPT1 depletion at 100 nM.
Medchemexpress LLC Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride | 2341841-02-7 | 99.3% | 410.81 | 100 MG
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, along with a linker. This compound is instrumental in designing PROTACs, which are molecules engineered to degrade specific target proteins. It functions by recruiting the E3 ubiquitin ligase to the target protein, leading to its ubiquitination and subsequent proteasomal degradation.
- Includes a ligand for an E3 ubiquitin ligase.
- Features a linker component.
- Used for the development of protein degraders.
- Purity of 99.30%.
- Available in solid form, white to off-white in color.
- Suitable for research purposes.
Medchemexpress LLC Thalidomide-NH-PEG3-propionic acid | 2138440-82-9 | 99.7% | 477.46 | 100 MG
Thalidomide-NH-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a 3-unit PEG linker used in PROTAC technology. This product is for research use only, intended for experienced personnel in appropriately equipped and authorized facilities.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Uses a 3-unit PEG linker
- Utilized in PROTAC technology
- Exploits intracellular ubiquitin-proteasome system for selective protein degradation
Medchemexpress LLC Thalidomide-NH-C5-NH2 hydrochloride | 2375194-03-7 | 99.86% | 394.85 | 50 MG
Thalidomide-NH-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. For research use only.
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Contains two different ligands connected by a linker
Medchemexpress LLC Thalidomide-O-C6-NHBoc | 2509093-23-4 | 95.99% | C24H31N3O7 | 100 MG
The product "Thalidomide-O-C6-NHBoc" is an E3 ligase ligand-linker conjugate. It is designed for use in PROTAC technology and incorporates a thalidomide-based cereblon ligand with a linker. It is intended for research use only and has a purity of 95.99%.
Features and benefits:
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a cereblon ligand
- Used in PROTAC technology
- Purity of 95.99%
- Available in various quantities for research needs
- Includes data sheet, COA, SDS, and handling instructions
- Soluble in DMSO
- Storage at -20°C (1 month) or -80°C (6 months) in solvent