Lactams
Medchemexpress LLC Thalidomide-O-amido-PEG4-propargyl | 2496687-00-2 | 98.0% | C26H31N3O10 | 50 MG
Thalidomide-O-amido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It is for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an alkyne group
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide-O-amido-C6-NH2 TFA | 1950635-14-9 | 99.8% | 544.48 | 500 MG
Thalidomide-O-amido-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker. It can be used in the synthesis of PROTACs.
- Can be used in the synthesis of PROTACs.
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Medchemexpress LLC (S)-Thalidomide | 841-67-8 | MFCD00210219 | 99.52% | 258.23 | 50 MG
(S)-Thalidomide is the S-enantiomer of Thalidomide. It exhibits immunomodulatory, anti-inflammatory, antiangiogenic, and pro-apoptotic effects. (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN).
- It is the S-enantiomer of thalidomide.
- It exhibits immunomodulatory effects.
- It has anti-inflammatory properties.
- It shows antiangiogenic effects.
- It possesses pro-apoptotic effects.
- It binds to cereblon (CRBN).
Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 TFA | 1957236-21-3 | MFCD31560482 | >98.0% | 572.5 g/mol | C24H27F3N4O9 | 5 MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a thalidomide-based cereblon E3 ligase ligand-linker conjugate provided as the trifluoroacetic acid (TFA) salt. It is intended as a building block for PROTAC synthesis, combining a thalidomide-derived CRBN-binding moiety with a three-unit polyethylene glycol (PEG3) spacer and a short C2 amine handle for conjugation.
- Provides a cereblon-binding thalidomide ligand for PROTAC design.
- Includes a PEG3 linker to improve solubility and flexibility.
- Features a C2 amine handle for facile coupling to warheads.
- Offered as the TFA salt to aid handling and stability.
- Supplied at high purity (>98%) suitable for synthetic use.
- Available in small research-scale quantities for method development.
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | N/A | 97.0% | 384.19 g/mol | C19H21BN2O6 | 5 MG
Thalidomide-pinacolborane is a thalidomide analogue bearing a pinacolborane (Bpin) group, used as a synthetic intermediate and as a ligand for E3 ligase in PROTAC research. Molecular formula C19H21BN2O6, molecular weight 384.19 g/mol. Manufacturer documentation lists CAS 2229725-98-6 and purity 97.0%. Recommended storage is -20°C under nitrogen; in solvent, -80°C (up to 6 months) or -20°C (up to 1 month) under nitrogen.
- Functionalized thalidomide analogue useful as a synthetic intermediate.
- Serves as a ligand for E3 ligase in PROTAC applications.
- High purity (97.0%) suitable for research use.
- Stable when stored under nitrogen at recommended temperatures.
- Available in small research sizes down to 5 mg.
Medchemexpress LLC Thalidomide-4-Br | 2093536-12-8 | MFCD31730866 | 96.7% | 337.13 g/mol | C13H9BrN2O4 | 5 MG
Thalidomide-4-Br is a brominated derivative of thalidomide supplied as a solid research reagent. It is active against bromodomains and is used in preclinical research on inflammation, tumor biology, and neurology. The compound is provided in small milligram quantities for screening, biochemical assays, and exploratory studies.
- Brominated thalidomide derivative with defined activity toward bromodomains.
- High purity suitable for biochemical and cellular research.
- Available in small-quantity packs for early-stage studies.
- Stable solid form with recommended cold storage for long-term retention.
- Documented chemical identifiers, including CAS and molecular formula, for traceability.
Medchemexpress LLC Thalidomide-5-O-C5-NH2 hydrochloride | 2761385-94-6 | 395.84 | C18H22ClN3O5 | 10 MG
Thalidomide-5-O-C5-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand provided as the hydrochloride salt for use in chemical biology research. It is designed for incorporation into ligand-linker conjugates and PROTAC constructs to recruit CRBN and enable targeted protein degradation. The material is supplied as a research-grade powder with recommended cold, light-protected storage conditions.
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | 95.0% | 384.19 g·mol⁻¹ | C19H21BN2O6 | 10 MG
Thalidomide-pinacolborane is a thalidomide-derived small molecule bearing a pinacol boronic ester (Bpin). It serves as an E3 ligase (cereblon) ligand useful in targeted protein degradation (PROTAC) research and as a synthetic intermediate for cross-coupling chemistries.
Medchemexpress LLC Thalidomide 4-chloro | 244057-36-1 | MFCD30188071 | 96.0% | 292.68 g·mol⁻¹ | C13H9ClN2O4 | 1 G
Thalidomide 4-chloro is a chlorinated thalidomide derivative that functions as a cereblon (E3 ligase) ligand and E3 ligase activator. It is used in PROTAC development and as a synthetic building block for further derivatization via substitution at the 4-chloro position. The compound is supplied as a solid and is characterized for research applications.
- Molecular formula: C13H9ClN2O4.
- Molecular weight: 292.68 g·mol⁻¹.
- CAS number: 244057-36-1.
- Appearance: solid (powder).
- Purity: 96.0%.
- Intended use: E3 ligase (cereblon) ligand for PROTAC design and derivatization.
- Storage: powder -20 °C (3 years) or 4 °C (2 years); in solvent -80 °C (6 months) or -20 °C (1 month).
Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.9% | 276.22 | 5 G
Thalidomide 4-fluoride is a Thalidomide-based Cereblon ligand that recruits CRBN protein and can be linked to the ligand for IRAK4 protein to create PROTAC IRAK4 degrader-1. This compound targets cereblon (CRBN), a ubiquitous protein involved in the cullin-4 E3 ubiquitin ligase complex CRL4, facilitating the ubiquitination and subsequent proteasomal degradation of target proteins.
- Recruits CRBN protein.
- Can be linked to IRAK4 protein ligand.
- Targets cereblon (CRBN).
- Facilitates ubiquitination and proteasomal degradation of target proteins.
- Molecular weight: 276.22.
- Physical state: solid.
- Color: off-white to gray.
- Soluble in DMSO.
- Store powder at -20°C for 3 years or 4°C for 2 years.
- Store in solvent at -80°C for 2 years or -20°C for 1 year.
- Avoid repeated freeze-thaw cycles after preparation into solution.
Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.8% | 276.22 | 100 G
Thalidomide 4-fluoride, also known as Cereblon ligand 4, is a Thalidomide-based Cereblon ligand. It is utilized in the recruitment of CRBN protein, a component of the cullin-4 E3 ubiquitin ligase complex. This compound mediates the ubiquitination and subsequent proteasomal degradation of target proteins, and can be connected to other ligands to form PROTAC degraders.
- Thalidomide-based cereblon ligand.
- Used in the recruitment of CRBN protein.
- Targets cereblon (CRBN), a part of the E3 ubiquitin ligase complex.
- Mediates ubiquitination and proteasomal degradation of target proteins.
- Can be used to form PROTAC degraders.
Medchemexpress LLC Thalidomide-4,5-F | 2222115-19-5 | 98.0% | 294.21 g/mol | C13H8F2N2O4 | 500 MG
Thalidomide-4,5-F is a fluorinated analogue of thalidomide that functions as a cereblon (CRBN) E3 ligase ligand for chemical biology and targeted protein degradation research. Identifiers: CAS 2222115-19-5; formula C13H8F2N2O4; molecular weight 294.21 g/mol. It is supplied as a research-grade solid with reported purity around 98.0%.
- Fluorinated analogue used as a cereblon E3 ligase ligand.
- Enables recruitment of CRBN for targeted protein degradation studies.
- Amenable to further derivatization via substitution at fluorine positions.
- High chemical purity (approximately 98.0%).
- Provided as a solid powder for research and analytical applications.
Sigma Aldrich Fine Chemicals Biosciences (+)-Thalidomide >=98% (HPLC), powder | 2614-06-4 | MFCD00210220 | 10MG
(+)-Thalidomide >=98% (HPLC), powder | Purity: >=98% (HPLC) | Mol Wt: 258.23 | 2614-06-4 | MFCD00210220 | 10MG
