Oxazinanes
Apexbio Technology LLC 5,6-Dihydro-UTP(Synonyms: 5,6-Dihydrouridine-5'-triphosphate, DHU-TP, 5,6-DHUTP, Dihydrouridine triphosphate), 50ul (100 mM).
5 6-Dihydro-UTP is a base-modified ribonucleoside triphosphate utilized in biochemical research Acting primarily as an acceptor substrate during enzymatic synthesis of dinucleoside polyphosphates this compound participates in phosphorylation reactions catalyzed by nucleotide-utilizing enzymes Due to its altered nucleobase structure 5 6-Dihydro-UTP serves as a strategic molecular probe in studies examining nucleotide synthesis pathways enzyme specificity and nucleic acid biochemistry
![eMolecules J&W PharmLab LLC cis-Octahydro-pyrrolo[23-c]pyridine-1-carboxylic acid tert-butyl ester 100mg 816498526 48R1026 96.000 949559-11-9 MFCD29049824 226.320 C12H22N2O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502694391.jpg-250.jpg)
eMolecules J&W PharmLab LLC cis-Octahydro-pyrrolo[23-c]pyridine-1-carboxylic acid tert-butyl ester 100mg 816498526 48R1026 96.000 949559-11-9 MFCD29049824 226.320 C12H22N2O2
J&W PharmLab LLC cis-Octahydro-pyrrolo[23-c]pyridine-1-carboxylic acid tert-butyl ester 100mg 816498526 48R1026 96.000 949559-11-9 MFCD29049824 226.320 C12H22N2O2
Medchemexpress LLC Tirbanibulin dihydrochloride | 1038395-65-1 | 98.0% | 504.45 g/mol | C26H31Cl2N3O3 | 100 MG
Tirbanibulin dihydrochloride is the dihydrochloride salt form of tirbanibulin supplied as an analytical research standard for in vitro testing and analytical applications. It functions as a Src inhibitor with reported GI50 values in the low nanomolar range in cancer cell lines.
- Analytical standard suitable for research use and assay development.
- Dihydrochloride salt form; molecular weight 504.45 g/mol.
- CAS number 1038395-65-1 for unambiguous identification.
- Purity (HPLC) 98.02% as stated on the certificate of analysis.
- Available in small pack sizes including 100 mg for analytical workflows.
Medchemexpress LLC (3-methyloxiran-2-yl)methanol | 872-38-8 | MFCD00033455 | 95.0% | 88.11 g/mol | C4H8O2 | 250 MG
(3-Methyloxiran-2-yl)methanol is an epoxide-containing small-molecule intermediate used in medicinal chemistry and organic synthesis. It is employed as a building block for preparing active compound derivatives and for ring-opening transformations. Typical analytical values include formula C4H8O2, molecular weight 88.11 g/mol, CAS 872-38-8, and reported purity around 95%. Supplied in milligram pack sizes for research use only.
- Epoxide functional group suitable for ring-opening reactions.
- Low molecular weight facilitates handling and purification.
- High reported purity for use as a synthetic intermediate.
- Available in small pack sizes useful for research-scale synthesis.
- Intended for research use only; not for clinical use.
Medchemexpress LLC TP-238 hydrochloride 10mM 1mL | 2415263-05-5 | 1 ML
TP-238 hydrochloride is the hydrochloride salt of TP-238, a potent and selective dual CECR2/BPTF probe used for biochemical and cellular studies of epigenetic reader domains. Offered as a 10 mM solution in DMSO and as solids, it is suitable for target validation and assay development.
- Potent dual CECR2 and BPTF inhibitor with IC50s of 30 nM and 350 nM.
- Additional inhibitory activity against BRD9 (pIC50 5.9).
- Available as a 10 mM DMSO solution (1 mL) and as solids (5-500 mg).
- Typical purity around 98.8% (source contains conflicting purity statements).
- Molecular weight 495.04 and formula C22H31ClN6O3S.
- Store at -20°C under inert atmosphere; in solvent store at -80°C up to 6 months.
TARGETMOL CHEMICALS INC SAMURACICLIB HYDROCHLORI 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Samuraciclib hydrochloride (ICEC0942 hydrochloride) is a potent selective ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochloride is 45- 15- 230- and 30-fold higher than CDK1 CDK2 (IC50 is 578 nM) CDK5 and CDK9 respectively. Samuraciclib hydrochloride inhibits the growth of breast cancer cell lines with GI50 values between 0.2-0.3 uM. Samuraciclib hydrochloride has anti-tumor effects. purity: 99%
AdipoGen Bupivacaine HCl monohydrate
Chemical. CAS 73360-54-0. Formula C18H28N2O . HCl . H2O. MW 288.4. 36.5 . 18.0. Synthetic. Bupivacaine is an amino amide local anesthetic that decreases current amplitude and inhibits whole cell K currents in Ca2-activated K channels and N-type voltage-gated KCNA and KCNC K channels. Bupivacaine also inhibits voltage-gated Na channels and tandem pore domain TASK-2/KCNK-5 K channels. The compound is cytotoxic at high concentrations inducing apoptosis and/or necrosis by interference with the mitochondrial energy transduction. Shown to inhibit aerobic ATP synthesis by i uncoupling of the oxidative phosphorylation OXPHOS and ii inhibition of the complex I of the respiratory. Other mechanisms include inhibition of the carnitine-acylcarnitine translocase or activation of the mitochondrial permeability transition pore MPTP.
Cayman Chemical DLthreoPDMP hydrochloride
An inhibitor of sphingolipid biosynthesis; inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates at 5 and 10 µM; reduces the synthesis of glucosylceramide increases cellular ceramide, and induces cell cycle arrest; increases Aβ42 and Aβ39 production independent of ceramide metabolism via modulation of γ-secretase activity
Cayman Chemical Dimebolin hydrochloride
A neuroprotective agent; binds to histamine H1 and H2 receptors (IC50s = 3.8 and 287 nM, respectively), as well as α1A-, α1B-, α1D-, and α2A-ARs, imidazoline I2 receptors, and 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 receptors (Kis = 8-313 nM); inhibits NMDA-evoked currents and voltage-gated calcium channels in mouse primary striatal neurons (IC50s = 10 and 50 μM, respectively); inhibits glutamate-induced apoptosis in primary striatal neurons derived from the YAC128 transgenic mouse model of Huntington’s disease at 50 μM; inhibits cell death induced by amyloid-β (25-35) in cerebellar granule cells at 25 μM; inhibits decreases TWAA acquisition in a rat model of AF64A-induced Alzheimer’s disease at 1 mg/kg
Cayman Chemical GW 3965 hydrochloride
An orally-active agonist of LXRα and LXRβ, activating the human isoforms with EC50 values of 190 and 30 nM, respectively; alters LXR-regulated gene expression in mice and rats, affecting pathways related to glucose and lipid metabolism
Cayman Chemical EthylLNIO hydrochloride
A modestly selective NOS inhibitor with Ki values for inhibition of nNOS, eNOS, and iNOS of 5.3, 18, and 12 µM, respectively; however, does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively)
Cayman Chemical SB242084 hydrochloride
An antagonist of the 5-HT2C receptor (pKi = 9.0), with at least 100-fold more selectivity over other 5-HT, dopamine, or adrenergic receptors; brain penetrant with significant anxiolytic activity; used extensively in animal research
Cayman Chemical SRT 1720 hydrochloride
A selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol; improves insulin sensitivity, lowers plasma, glucose and increases mitochondrial capacity in diet-induced obese and diabetic leptin-deficient ob/ob mice after one week of treatment with an oral dose of 100 mg/kg once daily.
Cayman Chemical ClAmidine hydrochloride
A PAD inhibitor (IC50s = 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4, respectively); cytotoxic to HL-60, MCF-7, and HT-29 cancer cells (IC50s = 0.25, 0.05, and 1 μM, respectively); reduces ex vivo extracellular NET formation and increases survival in a mouse model of CLP-induced sepsis at 50 mg/kg; decreases the citrulline content in serum and joints and reduces the development of IgG autoantibodies in a mouse model of collagen-induced arthritis
Cayman Chemical 1 3 7-TrImethylurIc AcId 250mg
A metabolite of caffeine; scavenges hydroxyl radicals in a cell-free assay at 500 µM; inhibits t-butyl hydroperoxide-induced lipid peroxidation by 56.5% in isolated human erythrocyte membranes