Oxazinanes
AdipoGen Verapamil hydrochloride
Chemical. CAS 152-11-4. Formula C27H38N2O4 . HCl. MW 491.06. Synthetic Verapamil hydrochloride is an alpha-adrenergic receptor alpha-AR antagonist and calcium channel protein inhibitor that blocks the L-type Ca2 channels in smooth and cardiac muscle cells. Verapamil is an antiarrhythmic agent and vasodilator known to reduce the renal clearance of digoxin and induce apoptosis in primary and metastatic colon adenocarcinoma human cell lines in vitro. It has been observed that verapamil can induce currents by itself, presumably by acting on the potassium and chloride leakage. Verapamil has also been used as an inhibitor of drug efflux pump proteins such as Mdr P-glycoprotein. Verapamil is a substrate of CYP3A4 and CYP2C6. It is also used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Recent research has shown verapamil to be an effective treatment for diabetes in animal models.
AdipoGen 5-DTAF hydrochloride
Chemical. CAS 21811-74-5. Formula C23H12Cl2N4O5 . HCl. MW 495.3 . 36.5. Synthetic. 5-DTAF is highly reactive with proteins. Unlike other reactive fluoresceins, 5-DTAF not only reacts with amino groups, but also reacts with thiol groups and even directly reacts with hydroxy groups such as polysaccharides and other alcohols in aqueous solution at pH above 9. Due to its high reactivity, 5-DTAF is also used to label carbohydrates. Spectral properties Abs/Em = 492/517 nm
Innovative Research Inc Cow Myoglobin Pur Lyo 250mg
Bovine Myoglobin Purified Lyophilized 250mg - Bovine Myoglobin Purified Lyophilized from Innovative Research is a dialyzed, lyophilized powder. A core responsibility of this globular protein is to store oxygen in cardiac and skeletal muscle. This product should be protected from moisture.
Selleck Chemical LLC Propacetamol hydrochloride S4867-1g
Propacetamol hydrochloride (PRO) is a water-soluble prodrug of paracetamol (PA) which can be parenterally administered as analgesic for the treatment of postoperative pain acute trauma and gastric and/or intestinal disorders
Cayman Chemical Amiodaroned4 hydrochloride
An internal standard for the quantification of amiodarone by GC- or LC-MS
Medchemexpress LLC Quisinostat (dihydrochloride) | 875320-31-3 | C21H28Cl2N6O2 | 5 MG
Quisinostat dihydrochloride is an orally active, potent pan-HDAC inhibitor with IC50s as low as 0.11 nM for HDAC1. This compound exhibits broad-spectrum antitumoral activity and can induce autophagy in neuroblastoma cells. It is intended for research use only.
- Orally active, potent pan-HDAC inhibitor
- Exhibits broad-spectrum antitumoral activity
- Induces autophagy in neuroblastoma cells
- Inhibits HDAC isozymes in vitro
- Shows broad-spectrum antiproliferative activity against cancer cell lines
- Induces apoptosis
- Induces H3 and H4 acetylation in A2780 ovarian carcinoma cells
- Inhibits growth of pre-established HCT116 colon xenografts in vivo
Medchemexpress LLC Quisinostat dihydrochloride | 875320-31-3 | C21H28Cl2N6O2 | 1 MG
Quisinostat dihydrochloride is an orally active, potent pan-HDAC inhibitor that demonstrates broad-spectrum antitumoral activity and can induce autophagy in neuroblastoma cells.
- Potent pan-HDAC inhibitor
- Exhibits broad-spectrum antitumoral activity
- Induces autophagy in neuroblastoma cells
- High purity of 99.05%
- Inhibits HDAC isozymes
- Displays broad-spectrum antiproliferative activity against solid and hematologic cancer cell lines
- Induces apoptosis
- Induces continuous H3 acetylation in tumor tissue in vivo
- Strongly inhibits the growth of large pre-established HCT116 colon xenografts
Selleck Chemical LLC Ribociclib hydrochloride S5187-25mg
Ribociclib (LEE011) hydrochloride is a highly specific dual inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM respectively
Selleck Chemical LLC Ellipticine hydrochloride
Ellipticine Hydrochloride (NSC 71795 PZE) is a potent inhibitor of DNA topoisomerase II and forms covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases Ellipticine Hydrochloride is a natural product isolated from the Australian evergreen tree of the Apocynaceae family with antineoplastic activity
TARGETMOL CHEMICALS INC Protriptyline hydrochloride
Also available in 1 mL, 10 mg, 25 mg and bulk. Please contact Fisher for quotes. Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with an antidepressant property. Protriptyline hydrochloride (Protriptyline HCl) blocks the re-uptake of norepinephrine and serotonin by nerve terminals, thereby increasing available norepinephrine and serotonin. In addition, this agent exhibits anticholinergic activity. Purity 99.98%
TARGETMOL CHEMICALS INC Palonosetron hydrochloride
Also available in 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Palonosetron hydrochloride (RS 25259) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting. Purity 99.97%
TARGETMOL CHEMICALS INC Bendamustine hydrochloride
Also available in 1 mL, 25 mg, 50 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Bendamustine hydrochloride (EP-3101) (IC50 of 50 uM) is an alkylating agent associated with DNA damage. Purity 98.03%
TARGETMOL CHEMICALS INC Atomoxetine hydrochloride
Also available in 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Although its precise mechanism of action is unknown, atomoxetine appears to selectively inhibit the pre-synaptic norepinephrine transporter, resulting in inhibition of the presynaptic reabsorption of norepinephrine and prolongation of norepinephrine activity in the synaptic cleft. The effect on cognitive brain function may result in improved attention and decreased impulsivity and activity levels. Purity 99.8%
eMolecules 132073-83-7 | (S)-Morpholin-2-ylmethanol | Ambeed | MFCD09260718 | 117.148 | C5H11NO2 | 95.000 | OC[C@@H]1CNCCO1 | 1g | 572955357
(S)-Morpholin-2-ylmethanol | Ambeed | 132073-83-7 | MFCD09260718 | 117.148 | C5H11NO2 | 95.000 | OC[C@@H]1CNCCO1 | 1g | 572955357
![eMolecules 107-50-6 | Tetradecamethylcycloheptasiloxane | Toronto Research Chemicals | MFCD30534308 | 519.078 | C14H42O7Si7C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 | 250mg | 483437714](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502176831.JPG-250.jpg)
eMolecules 107-50-6 | Tetradecamethylcycloheptasiloxane | Toronto Research Chemicals | MFCD30534308 | 519.078 | C14H42O7Si7C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 | 250mg | 483437714
Tetradecamethylcycloheptasiloxane | Toronto Research Chemicals | 107-50-6 | MFCD30534308 | 519.078 | C14H42O7Si7C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 | 250mg | 483437714