Oxazinanes
Apexbio Technology LLC AMTB hydrochloride 1mg
AMTB hydrochloride (CAS 926023-82-7) is a selective antagonist of the TRPM8 ion channel effectively inhibiting TRPM8-mediated activation induced by agonists such as icilin with a reported pIC50 of approximately 6 23 In addition to its primary action AMTB hydrochloride also exhibits non-selective inhibitory effects on voltage-gated sodium channels (NaV) This compound is commonly utilized in biomedical research to investigate the role of TRPM8 channel activity alterations in the pathophysiology of bladder overactivity and bladder pain syndrome
Medchemexpress LLC Thz1 (hydrochloride) | 99.1% | C31H29Cl2N7O2 | 10MM/1ML
THZ1 Hydrochloride is a selective and potent covalent inhibitor of CDK7, with an IC50 of 3.2 nM. It also inhibits the closely related kinases CDK12 and CDK13, leading to the downregulation of MYC expression.
- Functions as a selective and potent covalent CDK7 inhibitor.
- Inhibits closely related kinases, specifically CDK12 and CDK13.
- Downregulates MYC expression.
Selleck Chemical LLC GPNA hydrochloride
GPNA hydrochloride (L- -glutamyl-p-nitroanilide hydrochloride) is a substrate of -glutamyltransferase (GGT) and an inhibitor of the glutamine transporter ASCT2 with an IC50 of 250 M in A549 cells It also inhibits Na -dependent carriers SNAT1 -2 -4 -5 and Na -independent leucine transporters LAT1/2 It can be widely used in research on pancreatic cancer breast cancer glioblastoma multiforme acute myelogenous leukemia and non-small-cell lung cancer
Chemscene ChemScene | 4-(Morpholino)phenylboronic acid | 5G | CS-W009091 | 0.98 | 186498-02-2| MFCD03095169 | 207.038
ChemScene | 4-(Morpholino)phenylboronic acid | 5G | CS-W009091 | 0.98 | 186498-02-2| MFCD03095169 | 207.038
Selleck Chemical LLC ICCB-19 hydrochloride
ICCB-19 hydrochloride is an inhibitor of TNFRSF1A Associated Via Death Domain (TRADD) with IC50 of 1 12 M and 2 01 M for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs respectively ICCB-19 indirectly inhibits Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) ICCB-19 effectively induces autophagy
TARGETMOL CHEMICALS INC Neboglamine hydrochloride 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Neboglamine (CR-2249, XY-2401) hydrochloride, an orally active positive modulator of the NMDA receptor glycine site, can be used in schizophrenia research [1]. Purity 99.11%
Medchemexpress LLC 13,14-Dihydro-15-keto-PGE2-d9 | 2750534-81-5 | 361.52 | 25 UG
13,14-Dihydro-15-keto-PGE2-d9 is the deuterium labeled 13,14-Dihydro-15-keto-PGE2. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled compound
- Incorporates stable heavy isotopes of hydrogen, carbon, and other elements
- Affects pharmacokinetic and metabolic profiles of drugs
- For research use only
Apexbio Technology LLC Tipiracil hydrochloride 183204-72-0 10mM (in 1mL H2O)
Tipiracil hydrochloride (CAS 183204-72-0) is a small-molecule inhibitor of thymidine phosphorylase (TP) an enzyme involved in the pyrimidine nucleoside salvage pathway By inhibiting TP tipiracil reduces the degradation of thymidine analogs thereby maintaining higher plasma concentrations of compounds such as trifluridine (FTD) when co-administered Tipiracil in combination with FTD constitutes the oral antitumor agent TAS-102 which is under clinical investigation In research settings tipiracil is used to enhance the pharmacological activity of nucleoside analogs by limiting their metabolic breakdown supporting studies on antitumor therapeutics and nucleotide metabolism
Cayman Chemical CP 24 879 hydrochloride
A Δ5/Δ6 desaturase inhibitor; reduces liver arachidonate content by ~50% in mice at 3 mg/kg; increases mead acid content and inhibits leukotriene C4 synthesis in murine mastocytoma cells at 5 µM
Medchemexpress LLC 9-Dihydro-13-acetylbaccatin III (9-DHAB III) | 142203-65-4 | 99.6% | C33H42O12 | 1 ML
9-Dihydro-13-acetylbaccatin III (9-DHAB III) is an intermediate used in the preparation of paclitaxel analogs. This compound exhibits antiproliferative activity against mouse P388 cells, as determined by MTT assay.
- Intermediate for paclitaxel analog preparation
- Purity of 99.6%
- White to off-white solid appearance
- Classified as terpenoids and diterpenoids
- Derived from Taxus chinensis plants
- Demonstrates antiproliferative activity against P388 cells
- Powder stable for up to 3 years at -20°C or 2 years at 4°C
- Solution stable for up to 2 years at -80°C or 1 year at -20°C
- Soluble in DMSO at 20 mg/mL
TARGETMOL CHEMICALS INC Valganciclovir hydrochloride
Also available in 1 mL, 10 mg, 25 mg, 50 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Valganciclovir hydrochloride (Valganciclovir HCl) is a hydrochloride salt form of valganciclovir, a prodrug form of ganciclovir, a nucleoside analog of 2'-deoxyguanosine, with antiviral activity. After phosphorylation, valganciclovir is incorporated into DNA, resulting in inhibition of viral DNA polymerase, and viral replication. Purity 98.55%
Selleck Chemical LLC ICCB-19 hydrochloride
ICCB-19 hydrochloride is an inhibitor of TNFRSF1A Associated Via Death Domain (TRADD) with IC50 of 1 12 M and 2 01 M for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs respectively ICCB-19 indirectly inhibits Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) ICCB-19 effectively induces autophagy