Oxazinanes
Medchemexpress LLC 7,8-Dihydro-L-biopterin (Standard) | 6779-87-9 | 99.8% | 239.23 | 10 MG
7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. It is the main metabolite of 4-amino-tetrahydro-L-biopterin, and it undergoes photooxidation to form biopterin. It promotes the conversion of nitric oxide synthase to a superoxide-producing form, thereby increasing oxidative stress levels in the renal outer medulla and inducing apoptosis. It is sensitive to the inhibitory effect of SOD.
- Can be applied to research related to salt-sensitive hypertension.
- Can be applied to research related to moderate to severe traumatic brain injury.
- Can be applied to research related to neurodegenerative diseases.
Medchemexpress LLC Ipatasertib dihydrochloride | 1396257-94-5 | C24H34Cl3N5O2 | 1 G
Ipatasertib dihydrochloride is a highly selective and ATP-competitive pan-Akt inhibitor, demonstrating significant selectivity against Akt1, Akt2, and Akt3. It is intended for research use only.
- Highly selective and ATP-competitive pan-Akt inhibitor
- IC50s of 5, 18, and 8 nM for Akt1, Akt2, and Akt3, respectively
- Exhibits over 600-fold and over 100-fold selectivity for Akt1 against PKA and p70S6K
- Effective in xenograft models with Akt activation
- Achieves tumor growth delay, stasis, or regression in vivo
Medchemexpress LLC Quisinostat (dihydrochloride) | 875320-31-3 | C21H28Cl2N6O2 | 5 MG
Quisinostat dihydrochloride is an orally active, potent pan-HDAC inhibitor with IC50s as low as 0.11 nM for HDAC1. This compound exhibits broad-spectrum antitumoral activity and can induce autophagy in neuroblastoma cells. It is intended for research use only.
- Orally active, potent pan-HDAC inhibitor
- Exhibits broad-spectrum antitumoral activity
- Induces autophagy in neuroblastoma cells
- Inhibits HDAC isozymes in vitro
- Shows broad-spectrum antiproliferative activity against cancer cell lines
- Induces apoptosis
- Induces H3 and H4 acetylation in A2780 ovarian carcinoma cells
- Inhibits growth of pre-established HCT116 colon xenografts in vivo
Selleck Chemical LLC Alprenolol hydrochloride
Alprenolol hydrochloride is the hydrochloride salt form of alprenolol which is an beta adrenergic receptorantagonist and is used as an antihypertensive anti-anginal and anti-arrhythmic agent
Selleck Chemical LLC Cloperastine hydrochloride
Cloperastine (HT-11) is a drug with a central antitussive effect and is also endowed with an antihistaminic activity
Medchemexpress LLC Xamoterol hemifumarate | 73210-73-8 | MFCD00661103 | 99.9% | 397.43 g/mol | C20H29N3O9 | 50 MG
Xamoterol hemifumarate is a selective, potent beta1-adrenergic receptor agonist used as a research reagent to study arrhythmogenesis and the relationship between β1-adrenergic stimulation and IKr.
- Selective beta1-adrenergic receptor agonist.
- Suitable for research into arrhythmogenesis and cardiac electrophysiology.
- Available in small solid quantities, including 50 MG.
- High purity (≈99.9%).
- Suitable for sealed, low-temperature storage.
- Includes CAS number 73210-73-8 for substance identification.
Selleck Chemical LLC KHS101 hydrochloride
KHS101 is a small-molecule inhibitor of TACC3 which is a key component of centrosome-microtubule dynamic networks
Medchemexpress LLC Rhodamine B isothiocyanate | 36877-69-7 | 95.7% | 536.09 | 10 MG
Rhodamine B isothiocyanate (RBITC) is a fluorescent dye used in biological imaging and labeling applications. It features an isothiocyanate functional group that allows for covalent attachment to amino groups on proteins and other biomolecules. This makes it suitable for fluorescent labeling of cells and tissues.
- Emits a bright orange-red fluorescence when excited by green light.
- Facilitates the detection and tracking of labeled molecules within complex samples.
- Offers stability and sensitivity, making it useful in cell biology, immunology, and neurobiology.
- Can be utilized as a biochemical reagent for life science-related research.
Apexbio Technology LLC Berbamine hydrochloride 6078-17-7 1g
Berbamine hydrochloride (CAS 6078-17-7) is an isoquinoline alkaloid derivative isolated from plants of the Berberidaceae family It exerts its biological effects primarily through modulation of various signaling pathways including inhibition of STAT3 activation and disruption of calcium homeostasis in cells Berbamine hydrochloride has been investigated for its ability to suppress proliferation and induce apoptosis in multiple cancer cell types as well as for its immunomodulatory properties This compound serves as a valuable tool for studies exploring mechanisms of tumorigenesis and evaluating potential therapeutic strategies in cancer and immune-related research
Medchemexpress LLC Sapropterin dihydrochloride | 69056-38-8 | 99.9% | C9H17Cl2N5O3 | 1 MG
Sapropterin dihydrochloride is an analytical standard intended for research and analytical applications. This compound is an orally active phenylalanine hydroxylase (PAH) cofactor that effectively reduces blood phenylalanine concentrations. It can be used in the study of phenylketonuria (PKU) and may also aggravate experimental autoimmune encephalomyelitis (EAE).
- Analytical standard for research and analytical applications.
- Orally active phenylalanine hydroxylase (PAH) cofactor.
- Effectively reduces blood phenylalanine concentrations.
- Used in the study of phenylketonuria (PKU).
- May aggravate experimental autoimmune encephalomyelitis (EAE).
- Commonly used in qualitative, quantitative, and methodological research experiments.
- Suitable for HPLC, GC, and MS applications.
Accela Chembio Inc 3-morpholinoaniline | 25g | 159724-40-0 | MFCD03197165 | 97+% | Shelf Life: 1800 Days | Light Sensitive/+4
3-morpholinoaniline | 25g | 159724-40-0 | MFCD03197165 | 97+% | Shelf Life: 1800 Days | Light Sensitive/+4
TARGETMOL CHEMICALS INC Milnacipran hydrochloride
Also available in 10 mg, 25 mg, 50 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Milnacipran hydrochloride (Savella) is a serotonin and norepinephrine reuptake inhibitor used to treat major depressive disorders. Milnacipran hydrochloride is an enantiomer of milnacipran, which is used to treat fibromyalgia. Milnacipran hydrochloride and milnacipran have been associated with a low rate of transient elevations in serum aminotransferase levels during treatment and with rare instances of clinically apparent acute liver injury with jaundice. Purity 100%
TARGETMOL CHEMICALS INC Normetanephrine hydrochloride
Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Normetanephrine hydrochloride (DL-Normetanephrine hydrochloride) is a metabolite of Epinephrine. It is found together with Metanephrine in urine and in certain tissues. Purity 99.16%
Selleck Chemical LLC Cariprazine hydrochloride
Cariprazine hydrochloride(RGH188 hydrochloride) is a novel antipsychotic agent and is a highly selective partial agonist of dopamineD2 and D3 and 5HT1A receptors with preferential binding to the D3 receptor It exhibits high selectivity and affinity to dopamine D3 (Ki 0 085 nM) and D2 (Ki 0 49 nM) receptors and has moderate affinity for the 5-HT1A receptor (Ki 2 6 nM)