Oxazinanes
TARGETMOL CHEMICALS INC VESAMICOL HYDROCHLORIDE 5MG
Also available in 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Vesamicol hydrochloride ((±)-AH5183 hydrochloride) is a acetylcholine transport inhibitor. purity: 98%
TARGETMOL CHEMICALS INC FLUOXETINE HYDROCHLORIDE 200MG
Also available in 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Fluoxetine hydrochloride (Lilly110140) is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants. purity: 99%
Cayman Chemical EthylLNIO hydrochloride
A modestly selective NOS inhibitor with Ki values for inhibition of nNOS, eNOS, and iNOS of 5.3, 18, and 12 µM, respectively; however, does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively)
TARGETMOL CHEMICALS INC GPNA HYDROCHLORIDE 50MG
Also available in 10 mg 25 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme (gamma)-glutamyltransferase (GGT). GPNA hydrochloride also inhibits Na+-dependent carriers such as SNAT family (SNAT1/2/4/5) and the Na+-independent leucine transporters LAT1/2. purity: 99%
Apexbio Technology LLC Pargyline (hydrochloride) 306-07-0 5g
Pargyline (hydrochloride) (CAS 306-07-0) is an irreversible non-selective inhibitor of monoamine oxidases (MAO) targeting both MAO-A (IC 11 52 nM) and MAO-B (IC 8 2 nM) MAO-A predominantly deaminates neurotransmitters such as melatonin serotonin norepinephrine and epinephrine while MAO-B primarily acts on certain catecholamines In vitro pargyline inhibits proliferation and induces G1 phase cell cycle arrest and apoptosis in human prostate carcinoma (LNCaP-LN3) cells In vivo studies in rats have shown that pargyline administration increases striatal extracellular dopamine levels and decreases MAO-derived metabolites These properties support its utility in neuropharmacological and oncology research
![eMolecules Synthonix tert-butyl N-[(1R2S)-2-aminocyclobutyl]carbamate 1g 808545757 B84262 1932344-68-7 [null] 186.255 C9H18N2O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502694490.jpg-250.jpg)
eMolecules Synthonix tert-butyl N-[(1R2S)-2-aminocyclobutyl]carbamate 1g 808545757 B84262 1932344-68-7 [null] 186.255 C9H18N2O2
Synthonix tert-butyl N-[(1R2S)-2-aminocyclobutyl]carbamate 1g 808545757 B84262 1932344-68-7 [null] 186.255 C9H18N2O2
TARGETMOL CHEMICALS INC DROXIDOPA 25MG
Also available in 1 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Droxidopa (L-DOPS) is an orally available prodrug of norepinephrine that is used in the treatment of symptomatic orthostatic hypotension due to neurogenic causes of autonomic failure. purity: 99%
eMolecules Glycinamide hydrochloride | Combi-Blocks | 1668-10-6 | MFCD00013008 | 110.540 | C2H7ClN2O | 98.000 | Cl.NCC(N)=O | 25g | 205411604
Glycinamide hydrochloride | Combi-Blocks | 1668-10-6 | MFCD00013008 | 110.540 | C2H7ClN2O | 98.000 | Cl.NCC(N)=O | 25g | 205411604
Cayman Chemical HA1077 hydrochloride
A potent inhibitor of ROCK2, PRK-2, MSK1, and MAPKAP-K1b with IC50 values of 1.9, 4, 5, and 15 µM, respectively; has been shown to reduce blood vessel constriction, decreases pulmonary arterial pressure, inhibit tumor angiogenesis, and improve insulin signaling in a diabetic rat model; drug forms are marketed for the treatment of pulmonary arterial hypertension and stable angina
Apexbio Technology LLC Tacrine hydrochloride 1684-40-8 10mM (in 1mL H2O)
Tacrine hydrochloride (CAS 1684-40-8) is a small molecule inhibitor of cholinesterases exhibiting potent inhibitory activity against both acetylcholinesterase (AChE IC 31 nM) and butyrylcholinesterase (BChE IC 25 6 nM) in vitro Additionally it has been shown to inhibit N-methyl-D-aspartate receptors (NMDARs) with an IC of approximately 26 M By modulating both cholinergic and glutamatergic signaling pathways tacrine hydrochloride is frequently employed in studies investigating the molecular mechanisms underlying Alzheimer s disease and exploring potential therapeutic strategies for neurodegenerative disorders
Medchemexpress LLC Quizartinib dihydrochloride | 1132827-21-4 | 99.8% | 633.59 g·mol⁻1 | C29H34Cl2N6O4S | 5 MG
Quizartinib dihydrochloride is the dihydrochloride salt form of quizartinib, a second-generation, highly selective type II FLT3 tyrosine kinase inhibitor used in preclinical oncology research. It demonstrates low-nanomolar potency against FLT3 and FLT3-ITD and is employed in cellular assays and medicinal chemistry applications, including degrader design. The material is supplied at research scale with high reported purity.
- High potency FLT3 inhibition in the low-nanomolar range.
- Suitable for in vitro and preclinical AML models.
- Compatible with PROTAC linker chemistry and conjugation studies.
- Supplied as the dihydrochloride salt for improved solubility.
- High purity suitable for biochemical and cellular assays.
- Available in multiple small research pack sizes.
Selleck Chemical LLC VU0357017 Hydrochloride
VU0357017 hydrochloride (CID-25010775) is a potent highly selective and CNS-penetrant agonist of M1 which is a subtype of muscarinic acetylcholine receptors (mAChRs) VU0357017 hydrochloride appears to act at an allosteric site to activate the receptor with EC50 of 477 nM and Ki of 9 91 M
Selleck Chemical LLC PF-543 hydrochloride
PF-543 hydrochloride a novel sphingosine-competitive inhibitor of SphK1 inhibits SphK1 with IC50 and Ki of 2 0 nM and 3 6 nM exhibits 100-fold selectivity over the SphK2 isoform PF-543 hydrochloride induces apoptosis necrosis and autophagy
TARGETMOL CHEMICALS INC Valacyclovir hydrochloride
Also available in 1 g, 1 mL, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an acyclovir prodrug that, upon metabolism, inhibits viral DNA replication. Purity 100%
Cayman Chemical SKF 96365 hydrochloride
Inhibits the receptor-mediated influx of calcium via voltage-gated calcium channels (IC50 = 10 µM); inhibits the acetylcholine-induced depolarization of circular smooth muscle in a dose-dependent manner at 3-50 µM