Oxazinanes
Medchemexpress LLC Pozanicline dihydrochloride | 161416-61-1 | 99.1% | 265.18 | 10 MG
Pozanicline dihydrochloride is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites. It is an α4β2-selective nAChR agonist, binding to rat brain α4β2 nAChR with a Ki of 17 nM, while its binding to α7 nAChR is insignificant.
- Acts as a partial agonist at α4β2 nAChR.
- Exhibits high selectivity for α6β2 and α4α5β2 nAChR subtypes.
- Reverses nicotine withdrawal-induced deficits in contextual fear conditioning.
- Investigated in phase 2 clinical trials for conditions such as attention deficit hyperactivity disorder, Alzheimer's disease, and nicotine addiction.
Apexbio Technology LLC YM-155 hydrochloride 355406-09-6 10mM (in 1mL DMSO)
YM-155 hydrochloride (CAS 355406-09-6) is a small molecule inhibitor that selectively targets survivin the smallest member of the inhibitor of apoptosis (IAP) protein family Unlike broader IAP inhibitors YM-155 preferentially reduces survivin expression without significantly affecting related family proteins or BCL-2 proteins Treatment with YM-155 has demonstrated antiproliferative activity across diverse human tumor cell lines and induced tumor regression in preclinical xenograft models of non-small cell lung cancer (NSCLC) melanoma bladder cancer aggressive non-Hodgkin lymphoma and breast cancer Additionally YM-155 reduced metastatic potential and prolonged survival in animal models bearing triple-negative breast cancer xenografts highlighting its utility in cancer research
Medchemexpress LLC Pramipexole dihydrochloride hydrate | 191217-81-9 | 98.0% | 1 ML
Pramipexole dihydrochloride hydrate is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM, and 1.3 nM for D2-type receptor, D2, D3, and D4 receptors, respectively. It can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).
- Selective and blood-brain barrier penetrant dopamine D2-type receptor agonist
- Used for research of Parkinson's disease (PD) and restless legs syndrome (RLS)
- Shows low binding affinity for D1-type receptor (>50,000 nM IC50)
- Attenuates levodopa-induced toxicity in mesencephalic cultures
- Significantly reduces infarction volume and improves neurological recovery
Medchemexpress LLC Flunarizine dihydrochloride | 30484-77-6 | 99.9% | 1 G
Flunarizine dihydrochloride is a potent dual Na+/Ca2+ channel (T-type) blocker and a D2 dopamine receptor antagonist. It exhibits anticonvulsive, antimigraine, and peripheral vasodilator effects.
- Potent dual Na+/Ca2+ channel (T-type) blocker
- D2 dopamine receptor antagonist
- Exhibits anticonvulsive activity
- Exhibits antimigraine activity
- Exhibits peripheral vasodilator effects
Medchemexpress LLC 7,8-Dihydro-L-biopterin | 6779-87-9 | 99.79% | 239.23 | 100 MG
7,8-Dihydro-L-biopterin is a NOS uncoupling inducer that can cross the blood-brain barrier. It is a reduced non-conjugated pteridine and the main metabolite of 4-amino-tetrahydro-L-biopterin, which undergoes photooxidation to form biopterin. This compound promotes the conversion of nitric oxide synthase to a superoxide-producing form, leading to increased oxidative stress in the renal outer medulla and inducing apoptosis.
- NOS uncoupling inducer
- Can cross the blood-brain barrier
- Promotes conversion of nitric oxide synthase to a superoxide-producing form
- Increases oxidative stress in the renal outer medulla
- Induces apoptosis
- Sensitive to inhibitory effect of SOD
- Used in research related to salt-sensitive hypertension and neurodegenerative diseases
Selleck Chemical LLC KHS101 hydrochloride
KHS101 is a small-molecule inhibitor of TACC3 which is a key component of centrosome-microtubule dynamic networks
Selleck Chemical LLC Vernakalant Hydrochloride
Vernakalant (RSD-1235 MK-6621) is a novel frequency-dependent Na channel and early activating K channel blocker that selectively prolongs the atrial refractory period
eMolecules Ambeed 2-Methyl-3-(trifluoromethyl)aniline 10g 552641659 A201436 54396-44-0 MFCD00153216 175.154 C8H8F3N
Ambeed 2-Methyl-3-(trifluoromethyl)aniline 10g 552641659 A201436 54396-44-0 MFCD00153216 175.154 C8H8F3N
![eMolecules AstaTech TERT-BUTYL (3S)-((3-FLUOROPYRROLIDIN-3-YL)METHYL)CARBAMATE 0.25g 601099117 AT27879 95.000 2165650-75-7 [null] 218.272 C10H19FN2O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502695500.jpg-250.jpg)
eMolecules AstaTech TERT-BUTYL (3S)-((3-FLUOROPYRROLIDIN-3-YL)METHYL)CARBAMATE 0.25g 601099117 AT27879 95.000 2165650-75-7 [null] 218.272 C10H19FN2O2
AstaTech TERT-BUTYL (3S)-((3-FLUOROPYRROLIDIN-3-YL)METHYL)CARBAMATE 0.25g 601099117 AT27879 95.000 2165650-75-7 [null] 218.272 C10H19FN2O2
eMolecules ChemScene N1-Methylbenzene-13-diamine 5g 632276135 CS-0019198 50617-73-7 MFCD11132708 122.171 C7H10N2
ChemScene N1-Methylbenzene-13-diamine 5g 632276135 CS-0019198 50617-73-7 MFCD11132708 122.171 C7H10N2
Medchemexpress LLC 8-Azaadenine | 1123-54-2 | 99.9% | 136.12 | 250 MG
8-Azaadenine is an inhibitor of Xanthine Oxidase with an IC50 of 0.54 μM and a Ki of 0.66 μM. It is produced via the metabolism of 8-Azaadenosine and can be incorporated into polynucleotide chains alongside 8-Azaguanine to impact purine metabolism. This product is used in cancer studies and can also be synthesized into various derivatives through alkylation reactions, which demonstrate antiviral activity.
- Inhibits Xanthine Oxidase with an IC50 of 0.54 μM and a Kᵢ of 0.66 μM
- Produced via the metabolism of 8-Azaadenosine
- Incorporated into polynucleotide chains to affect purine metabolism
- Used in the study of cancer
- Can be synthesized into derivatives with antiviral activity