Oxazinanes
Selleck Chemical LLC Tribenzagan Hydrochloride
Tribenzagan Hydrochloride (Trimethobenzamide) is an orally available antiemetic agent used in the therapy of nausea and vomiting associated with medications and gastrointestinal viral and other illnesses
Cayman Chemical EthylLNIO hydrochloride
A modestly selective NOS inhibitor with Ki values for inhibition of nNOS, eNOS, and iNOS of 5.3, 18, and 12 µM, respectively; however, does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively)
Medchemexpress LLC Quisinostat (dihydrochloride) | 875320-31-3 | C21H28Cl2N6O2 | 5 MG
Quisinostat dihydrochloride is an orally active, potent pan-HDAC inhibitor with IC50s as low as 0.11 nM for HDAC1. This compound exhibits broad-spectrum antitumoral activity and can induce autophagy in neuroblastoma cells. It is intended for research use only.
- Orally active, potent pan-HDAC inhibitor
- Exhibits broad-spectrum antitumoral activity
- Induces autophagy in neuroblastoma cells
- Inhibits HDAC isozymes in vitro
- Shows broad-spectrum antiproliferative activity against cancer cell lines
- Induces apoptosis
- Induces H3 and H4 acetylation in A2780 ovarian carcinoma cells
- Inhibits growth of pre-established HCT116 colon xenografts in vivo
Medchemexpress LLC S1ra (hydrochloride) | 1265917-14-3 | 99.9% | 373.88 | 250 MG
S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. It demonstrates good selectivity against σ2R (Ki >1000 nM). This compound is also identified as a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride has been shown to inhibit neuropathic pain and activity-induced spinal sensitization.
- Orally active and selective sigma-1 receptor (σ1R) antagonist
- High affinity for human and guinea pig σ1Rs
- Good selectivity against sigma-2 receptors (σ2R)
- Acts as a human 5-HT2B receptor antagonist
- Inhibits neuropathic pain
- Reduces activity-induced spinal sensitization
- Demonstrates analgesic effects on formalin-evoked nociceptive behaviors in mice
- Reverses capsaicin-induced mechanical hypersensitivity in mice
Selleck Chemical LLC Triflupromazine hydrochloride
Triflupromazine hydrochloride (Fluopromazine) is an antipsychotic medication of the phenothiazine class
Selleck Chemical LLC Pargyline hydrochloride S3690-1g
Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0 5 M for time-dependent inhibition of the activity of MAO-A and -B respectivey
Selleck Chemical LLC Irinotecan hydrochloride S5026-10mM/1mL
Irinotecan (CPT-11 ( )-Irinotecan) hydrochloride is an inhibitor of Topoisomerase I (Topo I) that exhibits cytotoxicity in LoVo cells and HT-29 cells with IC50 of 15 8 M and 5 17 M respectively
Selleck Chemical LLC Gatifloxacin hydrochloride
Gatifloxacin (AM-1155 CG5501 BMS-206584 PD135432) hydrochloride is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases with IC50 of 13 8 g/ml and 0 109 g/ml for S aureus topoisomerase IV and E coli DNA gyrase respectively
Medchemexpress LLC Decloxizine dihydrochloride | 13073-96-6 | 99.69% | C21H30Cl2N2O2 | 25 MG
Decloxizine dihydrochloride is a histamine 1 receptor antagonist.
- H1 receptor antagonist
- Suitable for neurological research
- Applicable in studies of eye or ear disease
- Relevant for metabolic or endocrine disease research
- Used in inflammation or immune system disease studies
- Involved in neurodegenerative disease research
- Related to lipid metabolism
- Applicable to Parkinson's disease research
- Relevant for obesity studies
- Used in endocrinology research
Medchemexpress LLC Ipatasertib dihydrochloride | 1396257-94-5 | C24H34Cl3N5O2 | 1 G
Ipatasertib dihydrochloride is a highly selective and ATP-competitive pan-Akt inhibitor, demonstrating significant selectivity against Akt1, Akt2, and Akt3. It is intended for research use only.
- Highly selective and ATP-competitive pan-Akt inhibitor
- IC50s of 5, 18, and 8 nM for Akt1, Akt2, and Akt3, respectively
- Exhibits over 600-fold and over 100-fold selectivity for Akt1 against PKA and p70S6K
- Effective in xenograft models with Akt activation
- Achieves tumor growth delay, stasis, or regression in vivo
Selleck Chemical LLC Tulobuterol hydrochloride
Tulobuterol is a long-acting 2-adrenergic receptor agonist that has bronchodilatory anti-inflammatory and antiviral activities
eMolecules Apollo Scientific 3 7-Dioxabicyclo[4 1 0]heptane 250mg 600856286 OR54673 95 000 286-22-6 MFCD11226853 100 117 C5H8O2
Apollo Scientific 3 7-Dioxabicyclo[4 1 0]heptane 250mg 600856286 OR54673 95 000 286-22-6 MFCD11226853 100 117 C5H8O2
eMolecules Pharmablock cyclohexane-1 2-dione 50mg 812210728 PBTEN8012 0 000 765-87-7 MFCD00001648 112 128 C6H8O2
Pharmablock cyclohexane-1 2-dione 50mg 812210728 PBTEN8012 0 000 765-87-7 MFCD00001648 112 128 C6H8O2
Medchemexpress LLC C24:1 Dihydro 1-deoxyceramide (m18:0/24:1) | 1246298-60-1 | 99.0% | 634.11 | 1 MG
C24:1 Dihydro 1-deoxyceramide (m18:0/24:1) is a lipid molecule composed of a long-chain fatty acid (24:1) and a 1-deoxysphingoid backbone. Deoxyceramide accumulates under conditions of obesity and type 2 diabetes (T2D). It cannot be further metabolized to more complex sphingolipid and is toxic when it accumulates in the body. Deoxyceramide increases in differentiated adipocytes in vitro. This product is for research use only.
- Composed of a long-chain fatty acid (24:1) and a 1-deoxysphingoid backbone.
- Accumulates under conditions of obesity and type 2 diabetes (T2D).
- Cannot be metabolized to more complex sphingolipids and is toxic upon accumulation.
- Increases in differentiated adipocytes in vitro.
- For research use only.
Selleck Chemical LLC KHS101 hydrochloride
KHS101 is a small-molecule inhibitor of TACC3 which is a key component of centrosome-microtubule dynamic networks