Oxazinanes
Apexbio Technology LLC ML-7 hydrochloride 110448-33-4 10mM (in 1mL DMSO)
ML-7 hydrochloride (CAS 110448-33-4) is a potent inhibitor of myosin light chain kinase (MLCK) with a reported Ki of 300 nM By inhibiting MLCK ML-7 modulates the phosphorylation state of myosin light chains a process implicated in the pathogenesis of cardiovascular disorders and ischemia/reperfusion (I/R) injury In vitro ML-7 suppresses neuregulin-1-induced sarcomere formation in cultured neonatal rat cardiomyocytes In vivo administration of ML-7 during I/R protocols in rat models significantly improves cardiac contractility and alters the expression of proteins involved in energy metabolism and cytoskeletal organization ML-7 is widely utilized as a research tool to dissect MLCK-dependent signaling pathways in cardiovascular and cellular physiology
Selleck Chemical LLC GPNA hydrochloride
GPNA hydrochloride (L- -glutamyl-p-nitroanilide hydrochloride) is a substrate of -glutamyltransferase (GGT) and an inhibitor of the glutamine transporter ASCT2 with an IC50 of 250 M in A549 cells It also inhibits Na -dependent carriers SNAT1 -2 -4 -5 and Na -independent leucine transporters LAT1/2 It can be widely used in research on pancreatic cancer breast cancer glioblastoma multiforme acute myelogenous leukemia and non-small-cell lung cancer
TARGETMOL CHEMICALS INC RS 17053 HYDROCHLORIDE 5MG
Also available in 2 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. RS 17053 hydrochloride is a potent and selective antagonist of (alpha)1A adrenoceptor. RS 17053 hydrochloride exhibits a pKi value of 9.1 in native cell membrane and a pA2 value of 9.8 in functional assays. purity: 99%
![eMolecules Pharmablock tert-butyl 3-amino-3-methyl-azepane-1-carboxylate 5g 719895415 PBWP717 1513512-18-9 [null] 228.336 C12H24N2O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502694795.jpg-250.jpg)
eMolecules Pharmablock tert-butyl 3-amino-3-methyl-azepane-1-carboxylate 5g 719895415 PBWP717 1513512-18-9 [null] 228.336 C12H24N2O2
Pharmablock tert-butyl 3-amino-3-methyl-azepane-1-carboxylate 5g 719895415 PBWP717 1513512-18-9 [null] 228.336 C12H24N2O2
Apexbio Technology LLC Tipiracil hydrochloride 183204-72-0 10mM (in 1mL H2O)
Tipiracil hydrochloride (CAS 183204-72-0) is a small-molecule inhibitor of thymidine phosphorylase (TP) an enzyme involved in the pyrimidine nucleoside salvage pathway By inhibiting TP tipiracil reduces the degradation of thymidine analogs thereby maintaining higher plasma concentrations of compounds such as trifluridine (FTD) when co-administered Tipiracil in combination with FTD constitutes the oral antitumor agent TAS-102 which is under clinical investigation In research settings tipiracil is used to enhance the pharmacological activity of nucleoside analogs by limiting their metabolic breakdown supporting studies on antitumor therapeutics and nucleotide metabolism
![eMolecules 850583-75-4 | 3,6-Di(2-thienyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione | Combi-Blocks, Inc. | MFCD20257907 | 300.350 | C14H8N2O2S2 | 98.000 | O=C1NC(=C2C(=O)NC(=C12)c1cccs1)c1cccs1 | 25g | 569293009](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502192398.JPG-250.jpg)
eMolecules 850583-75-4 | 3,6-Di(2-thienyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione | Combi-Blocks, Inc. | MFCD20257907 | 300.350 | C14H8N2O2S2 | 98.000 | O=C1NC(=C2C(=O)NC(=C12)c1cccs1)c1cccs1 | 25g | 569293009
3,6-Di(2-thienyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione | Combi-Blocks, Inc. | 850583-75-4 | MFCD20257907 | 300.350 | C14H8N2O2S2 | 98.000 | O=C1NC(=C2C(=O)NC(=C12)c1cccs1)c1cccs1 | 25g | 569293009
TARGETMOL CHEMICALS INC DONITRIPTAN HYDROCHLORID 25MG
Also available in 1 mg 2 mg 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Donitriptan hydrochloride (Donitriptan monohydrochloride) is a potent high efficacy agonist of 5-HT1B/1D receptors with pKis of 9.4 and 9.3 respectivelypurity: 99%
Medchemexpress LLC SP3N hydrochloride | 99.84% | 764.34 | 1 MG
SP3N hydrochloride is a specific degrader of the prolyl isomerase (FKBP12). The alkylamine of SP3N hydrochloride is metabolized to a reactive aldehyde (SP3CHO), which recruits the SCFFBXO22 ligase for FKBP12 degradation. SP3N hydrochloride may be used in research for cancer.
- Specific degrader of FKBP12.
- Metabolized to a reactive aldehyde (SP3CHO) which recruits SCFFBXO22 ligase for FKBP12 degradation.
- May be used in research for cancer.