Oxazinanes
Cayman Chemical Dimebolin (hydrochloride), Purity: ≥98%, CAS: 97657-92-6, 10 mg
A neuroprotective agent; binds to histamine H1 and H2 receptors (IC50s = 3.8 and 287 nM, respectively), as well as α1A-, α1B-, α1D-, and α2A-ARs, imidazoline I2 receptors, and 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 receptors (Kis = 8-313 nM); inhibits NMDA-evoked currents and voltage-gated calcium channels in mouse primary striatal neurons (IC50s = 10 and 50 μM, respectively); inhibits glutamate-induced apoptosis in primary striatal neurons derived from the YAC128 transgenic mouse model of Huntington’s disease at 50 μM; inhibits cell death induced by amyloid-β (25-35) in cerebellar granule cells at 25 μM; inhibits decreases TWAA acquisition in a rat model of AF64A-induced Alzheimer’s disease at 1 mg/kg
![Aobchem Ethanone 1-(3 -chloro[1 1 -biphenyl]-3-yl)- | ≥97% | CAS 893734-53-7 | C14H11ClO | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000979889.png-250.jpg)
Aobchem Ethanone 1-(3 -chloro[1 1 -biphenyl]-3-yl)- | ≥97% | CAS 893734-53-7 | C14H11ClO | 1g
Ethanone 1-(3 -chloro[1 1 -biphenyl]-3-yl)- | ≥97% | CAS 893734-53-7 | C14H11ClO | 1g
Aobchem 5-Bromo-2 3-dihydro-1H-indene-1-carboxylic acid | ≥95% | CAS 1132943-94-2 | C10H9BrO2 | 500mg
5-Bromo-2 3-dihydro-1H-indene-1-carboxylic acid | ≥95% | CAS 1132943-94-2 | C10H9BrO2 | 500mg
Aobchem 5-Bromo-2 3-dihydro-1H-indene-1-carboxylic acid | ≥95% | CAS 1132943-94-2 | C10H9BrO2 | 5g
5-Bromo-2 3-dihydro-1H-indene-1-carboxylic acid | ≥95% | CAS 1132943-94-2 | C10H9BrO2 | 5g
Aobchem 3-(4-Morpholinylcarbonyl)-5-(trifluoromethyl)phenylboronic acid | 97% | CAS 1264616-26-3 | C12H13BF3NO4 | 500mg
3-(4-Morpholinylcarbonyl)-5-(trifluoromethyl)phenylboronic acid | 97% | CAS 1264616-26-3 | C12H13BF3NO4 | 500mg
Aobchem 6-Bromo-2 3-dihydro-benzo[1 4]dioxine-5-carboxylic acid | ≥97% | CAS 69464-48-8 | C9H7BrO4 | 5g
6-Bromo-2 3-dihydro-benzo[1 4]dioxine-5-carboxylic acid | ≥97% | CAS 69464-48-8 | C9H7BrO4 | 5g
Cayman Chemical GW 3965 (hydrochloride), Purity: ≥98%, CAS: 405911-17-3, 10 mg
An orally-active agonist of LXRα and LXRβ, activating the human isoforms with EC50 values of 190 and 30 nM, respectively; alters LXR-regulated gene expression in mice and rats, affecting pathways related to glucose and lipid metabolism
Cayman Chemical HA-1077 (hydrochloride), Purity: ≥98%, CAS: 203911-27-7, 10 mg
A potent inhibitor of ROCK2, PRK-2, MSK1, and MAPKAP-K1b with IC50 values of 1.9, 4, 5, and 15 µM, respectively; has been shown to reduce blood vessel constriction, decreases pulmonary arterial pressure, inhibit tumor angiogenesis, and improve insulin signaling in a diabetic rat model; drug forms are marketed for the treatment of pulmonary arterial hypertension and stable angina
![Aobchem Ethanone 1-[3-[(4-methoxyphenyl)methoxy]phenyl]- | 97% | CAS 1016755-78-4 | C16H16O3 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5001008121.png-250.jpg)
Aobchem Ethanone 1-[3-[(4-methoxyphenyl)methoxy]phenyl]- | 97% | CAS 1016755-78-4 | C16H16O3 | 1g
Ethanone 1-[3-[(4-methoxyphenyl)methoxy]phenyl]- | 97% | CAS 1016755-78-4 | C16H16O3 | 1g
Cayman Chemical DL-threo-PDMP (hydrochloride), Purity: ≥98%, CAS: 80938-69-8, 50 mg
An inhibitor of sphingolipid biosynthesis; inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates at 5 and 10 µM; reduces the synthesis of glucosylceramide increases cellular ceramide, and induces cell cycle arrest; increases Aβ42 and Aβ39 production independent of ceramide metabolism via modulation of γ-secretase activity
Aobchem (2 4-Difluorophenyl)(morpholino)methanone | 97% | CAS 948717-49-5 | C11H11F2NO2 | 500mg
(2 4-Difluorophenyl)(morpholino)methanone | 97% | CAS 948717-49-5 | C11H11F2NO2 | 500mg