Oxazinanes
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Apexbio Technology LLC Tiagabine hydrochloride 145821-59-6 10mM (in 1mL DMSO)
Tiagabine hydrochloride (CAS 145821-59-6) is a selective inhibitor of the GAT-1 subtype -aminobutyric acid (GABA) transporter By blocking GAT-1-mediated reuptake tiagabine hydrochloride elevates extracellular GABA concentrations and potentiates GABAergic inhibitory neurotransmission Experimental studies demonstrate its capacity to suppress GABA uptake in neuronal glial and synaptic models at varying levels This compound is widely utilized in research on epileptic seizure mechanisms and for investigating neuroprotective effects in models of neurodegenerative disorders associated with disrupted GABA metabolism
