Piperazines

Apexbio Technology LLC Dexrazoxane 24584-09-6 25mg

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Dexrazoxane is a cell-permeable iron chelator that suppresses intracellular superoxide radical generation via iron sequestration thereby exhibiting antioxidant activity Dexrazoxane exerts its biological effects primarily by modulating oxidative stress and ferroptosis pathways In cell-based studies including myocardial H9c2 cell models dexrazoxane inhibits ferroptosis by suppressing the HMGB1 pathway and induces DNA damage and apoptosis in various tumor cell lines Based on these pharmacological properties dexrazoxane holds research potential in the study of cardioprotective mechanisms tumor-related DNA damage responses ferroptosis and oxidative stress processes

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eMolecules​ Medchem Express / JAK1-IN-8 / 5mg / 673358994 / HY-139423 / / 1973485-18-5 / MFCD30530428 / 442.510 / C22H23FN4O3S

Medchem Express / JAK1-IN-8 / 5mg / 673358994 / HY-139423 / / 1973485-18-5 / MFCD30530428 / 442.510 / C22H23FN4O3S

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Medchemexpress LLC Piperazine erastin | 1538593-71-3 | 99.1% | 645.19 g·mol⁻¹ | C35H41ClN6O4 | 1 MG

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Piperazine erastin is a small-molecule analog of erastin that triggers an iron-dependent form of non-apoptotic cell death known as ferroptosis. It is provided as a research reagent for cellular and biochemical studies investigating ferroptosis mechanisms and cancer biology.

• Induces iron-dependent ferroptosis in cell-based assays
• Suitable for studies of ferroptosis pathways and cancer research
• High purity appropriate for in vitro experiments
• Offered in small solid and solution quantities for laboratory use
• Stable when stored according to recommended temperature conditions

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Apexbio Technology LLC Y-39983 dihydrochloride 173897-44-4 5mg

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Y-39983 dihydrochloride (CAS 173897-44-4) is a selective inhibitor of Rho-associated coiled-coil containing protein kinase (ROCK) exhibiting an IC50 of 3 6 nM for ROCK inhibition It demonstrates substantially reduced inhibitory activity against protein kinase C (PKC IC50 0 42 M) and Ca2 /calmodulin-dependent protein kinase II (CaMKII IC50 0 81 M) In ex vivo studies Y-39983 dihydrochloride induces relaxation of pre-contracted rabbit ciliary arteries and has been shown to increase optic nerve head blood flow Furthermore dose-dependent reductions in intraocular pressure have been observed in both rabbit and monkey models These properties suggest its value for research on ROCK-related signaling in ocular physiology and vascular tone regulation

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eMolecules​ 2-TERT-BUTOXYCARBONY 500MG

5000189447 2-TERT-BUTOXYCARBONY 500MG

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eMolecules​ 1-(4-Chlorobenzoyl)piperazine | 54042-47-6 | MFCD01050442 | 1g

Combi-Blocks | 1-(4-Chlorobenzoyl)piperazine | 1g | 401044276 | ST-2200 | 95.000 | 54042-47-6 | MFCD01050442 | 224.690 | C11H13ClN2O

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Sigma Aldrich Fine Chemicals Biosciences S-2-Aminoethyl-L-cysteine1G

REAGENT S-2-Aminoethyl-L-cysteine1G

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TARGETMOL CHEMICALS INC Fluphenazine dihydrochloride

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Also available in 1 mL, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Fluphenazine dihydrochloride (Prolixin) is an inhibitor of phenothiazine-class D1DR and D2DR; In studies, Fluphenazine can be used to probe the effects and metabolic process of this commonly used dopamine antagonist. Purity 100%

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TARGETMOL CHEMICALS INC Ranolazine dihydrochloride

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Also available in 1 g, 1 mL, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Ranolazine dihydrochloride (Ranolazine 2HCl) , an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), and do not affect blood pressure or heart rate. Purity 100%

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TARGETMOL CHEMICALS INC H-89 dihydrochloride 25MG

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Also available in 1 mL, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50 0.14 uM, Ki 48 nM). Purity 99.4%

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TARGETMOL CHEMICALS INC Mitoxantrone dihydrochloride

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Also available in 1 mL, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Mitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor. Purity 98.63%

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Apexbio Technology LLC TMB dihydrochloride 64285-73-0 500mg

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TMB dihydrochloride (CAS 64285-73-0) is a water-soluble chromogenic substrate frequently employed in biochemical assays involving horseradish peroxidase (HRP) It is designed to enable enzyme-catalyzed colorimetric detection by generating an oxidized blue-colored product upon reaction with hydrogen peroxide TMB dihydrochloride exerts its functional role through HRP-catalyzed oxidation in the presence of hydrogen peroxide Based on its chemical reactivity it is also utilized as a probe for interactions with reactive oxygen and nitrogen species such as singlet oxygen hypochlorite hydrogen peroxide and nitrogen dioxide Based on these characteristics TMB dihydrochloride holds research potential in enzyme-linked immunosorbent assays (ELISA) immunohistochemical staining oxidative stress analysis and microbial metabolism studies

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Apexbio Technology LLC CP 31398 dihydrochloride 1217195-61-3 5mg

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CP 31398 dihydrochloride (CAS 1217195-61-3) is a small molecule that modulates the tumor suppressor protein p53 by stabilizing both wild-type and mutant forms thereby promoting p53-dependent transcriptional activity Through p53 pathway activation CP 31398 dihydrochloride increases p21 expression inhibits G1/S-phase cyclin-dependent kinase complexes and induces apoptosis in multiple cancer cell lines irrespective of p53 mutation status In various models including head and neck squamous cell carcinoma and colon adenocarcinoma it has demonstrated the ability to inhibit cancer cell proliferation and enhance the cytotoxic effects of chemotherapeutic agents Combined administration with celecoxib has been shown to significantly reduce both incidence and multiplicity of colon tumors in preclinical studies supporting its utility in cancer research and therapeutic strategy development

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Sigma Aldrich Fine Chemicals Biosciences Vilazodone hydrochloride >=98% (HPLC) | 163521-08-2 | MFCD00940014 | 10MG

Vilazodone hydrochloride >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 477.99 | 163521-08-2 | MFCD00940014 | 10MG

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Apexbio Technology LLC Copanlisib dihydrochloride 1402152-13-9 5mg

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Copanlisib dihydrochloride (CAS 1402152-13-9) is a small-molecule inhibitor that selectively targets phosphoinositide 3-kinase (PI3K) isoforms and By inhibiting these PI3K subunits copanlisib disrupts PI3K/AKT signaling pathways that regulate cellular proliferation and survival leading to reduced tumor cell growth and induction of apoptosis This compound is utilized in biomedical research to investigate PI3K-mediated oncogenic processes particularly in studies related to relapsed or refractory follicular lymphoma and other hematologic malignancies dependent on aberrant PI3K activity

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