Piperazines
![Medchemexpress LLC 2-(4-ethyl-piperazin-1-yl)-N-[4-(2-morpholinyl-4-oxo-4H-chromen-8-yl)-dibenzothiophenyl]-acetamide | 881375-00-4 | MFCD17214218 | ≥97.0% | 582.71 g/mol | C33H34N4O4S | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000222137.png-250.jpg)
Medchemexpress LLC 2-(4-ethyl-piperazin-1-yl)-N-[4-(2-morpholinyl-4-oxo-4H-chromen-8-yl)-dibenzothiophenyl]-acetamide | 881375-00-4 | MFCD17214218 | ≥97.0% | 582.71 g/mol | C33H34N4O4S | 5 MG
KU-0060648 is a small-molecule, ATP-competitive dual inhibitor of phosphoinositide 3-kinases (PI3K) and DNA-dependent protein kinase (DNA-PK), used in research to probe PI3K/DNA-PK signaling and to enhance chemosensitivity in cancer models. Reported enzymatic IC50 values are PI3Kα 4 nM, PI3Kβ 0.5 nM, PI3Kγ 0.1 nM, PI3Kδ 0.594 nM, and DNA-PK 8.6 nM.
- Dual inhibition of PI3K and DNA-PK for pathway interrogation.
- Low nanomolar potency against multiple PI3K isoforms and DNA-PK.
- Suitable for use in in vitro and in vivo research studies.
- Available in small-mass quantities for dose-ranging experiments.
- Powder form with defined storage conditions to preserve stability.
- Well-characterized chemical identity and molecular properties.
Medchemexpress LLC Piperazine erastin | 1538593-71-3 | 99.1% | 645.19 g·mol⁻¹ | C35H41ClN6O4 | 1 MG
Piperazine erastin is a small-molecule analog of erastin that triggers an iron-dependent form of non-apoptotic cell death known as ferroptosis. It is provided as a research reagent for cellular and biochemical studies investigating ferroptosis mechanisms and cancer biology.
- Induces iron-dependent ferroptosis in cell-based assays
- Suitable for studies of ferroptosis pathways and cancer research
- High purity appropriate for in vitro experiments
- Offered in small solid and solution quantities for laboratory use
- Stable when stored according to recommended temperature conditions
Medchemexpress LLC Dexrazoxane hydrochloride | 149003-01-0 | 99.8% | C11H18Cl2N4O4 | 5 MG
Dexrazoxane hydrochloride is a heart protectant used to preserve ovarian function and fertility. It exhibits antioxidant and anti-inflammatory properties and can cross the blood-brain barrier. It improves motor function disorders and offers neuroprotective effects, making it useful in neurodegenerative disease research. This EDTA derivative chelates iron, which reduces metal ion complexing with anthracycline and decreases superoxide radical formation. It protects the heart from cardiotoxic side effects of anthracyclines like doxorubicin.
- Helps preserve ovarian function and fertility
- Possesses antioxidant and anti-inflammatory properties
- Crosses the blood-brain barrier
- Improves motor function disorders
- Provides neuroprotective effects for neurodegenerative disease studies
- Chelates iron, reducing superoxide radical formation
- Protects the heart from anthracycline cardiotoxicity
Selleck Chemical LLC Minaprine dihydrochloride
Minaprine dihydrochloride is hydrochloride salt form of Minaprine which acts as a reversible inhibitor of MAO-A in rats and weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates
Accela Chembio Inc 1-(2-methoxyethyl)piperazine | 5g | 13484-40-7 | MFCD00191214 | 98% | D: 0.97 | Shelf Life: 1260 Days | Light Sensitive/n2
1-(2-methoxyethyl)piperazine | 5g | 13484-40-7 | MFCD00191214 | 98% | D: 0.97 | Shelf Life: 1260 Days | Light Sensitive/n2
Apexbio Technology LLC AMN 082 dihydrochloride 97075-46-2 25mg
AMN 082 dihydrochloride (CAS 97075-46-2) is a selective allosteric agonist of the metabotropic glutamate receptor 7 (mGluR7) a class C G protein-coupled receptor widely expressed in the nervous system In vitro AMN 082 activates human mGluR7 with an EC50 of 64 nM and induces receptor internalization in isolated hippocampal neurons at concentrations of 0 5 1 M increasing internalization to nearly threefold of control levels AMN 082 binds at a site distinct from the orthosteric glutamate pocket and its activity is not blocked by conventional competitive antagonists In vivo it crosses the blood-brain barrier and modulates stress hormone levels in wild-type but not mGluR7 knockout animals This compound is utilized for investigating mGluR7-mediated synaptic plasticity neuroprotection and stress-related neurological processes
Medchemexpress LLC N-(Tert-Butoxycarbonyl)-L-neopentylglycine | 79777-82-5 | 98.5% | C12H23NO4 | 5 G
N-(Tert-Butoxycarbonyl)-L-neopentylglycine is a Glycine derivative, also known by synonyms like L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-4-methyl- (9CI) and (S)-2-(tert-Butoxycarbonylamino)-4,4-dimethylpentanoic acid.
- For research use only
- Used as ergogenic supplements
- Influences secretion of anabolic hormones
- Supplies fuel during exercise
- Enhances mental performance during stress-related tasks
- Prevents exercise-induced muscle damage
- Recognized as a beneficial ergogenic dietary substance
TARGETMOL CHEMICALS INC Fluphenazine dihydrochloride
Also available in 1 mL, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Fluphenazine dihydrochloride (Prolixin) is an inhibitor of phenothiazine-class D1DR and D2DR; In studies, Fluphenazine can be used to probe the effects and metabolic process of this commonly used dopamine antagonist. Purity 100%
Medchemexpress LLC 4-((2-Aminoethyl)(5-chlorobenzo[d]oxazol-2-yl)amino)butan-2-one (dimethanesulfonate) | 1276666-12-6 | C15H24ClN3O8S2 | 10 G
4-((2-Aminoethyl)(5-chlorobenzo[d]oxazol-2-yl)amino)butan-2-one dimethanesulfonate (Suvorexant internate 2) is a pharmaceutical intermediate utilized in the synthesis of various active compounds. It is intended for laboratory use and the manufacture of substances, categorized within the 'Others' pathway.
- Drug intermediate
- Used for synthesizing various active compounds
- Laboratory chemical
- Used in the manufacture of substances
Apexbio Technology LLC H-9 dihydrochloride 116700-36-8 50mg
H-9 dihydrochloride (CAS 116700-36-8) is a cell-permeable inhibitor of protein kinase A (PKA) used extensively to investigate protein kinase-dependent cellular signal transduction pathways By antagonizing PKA activity H-9 dihydrochloride has been shown to attenuate cellular excitatory responses induced by serotonin (5-HT) and to directly influence physiological functions in the pharyngeal region Additionally in epithelial cell models H-9 dihydrochloride inhibits epidermal growth factor (EGF)-dependent signaling cascades suppressing cell proliferation This compound is widely used in cell biology research to dissect kinase-mediated regulatory mechanisms