Pyrazines
TARGETMOL CHEMICALS INC MMRI62 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. MMRi62 (7-[(23-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol) a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53 also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12. purity: 99%
TARGETMOL CHEMICALS INC EPIBERBERINE 25MG
Also available in 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. 1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPK(alpha)/Akt pathways during 3T3-L1 adipocyte differentiation. 3. Epiberberine as the brightest FSA emitter among the alkaloids can also serve as an efficient conformation probe for HTG DNA and discriminate the DNA G-quadruplex from the RNA counterpart. purity: 99%
TARGETMOL CHEMICALS INC IU1 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. IU1(IC50=4.7 u M) a reversible specific human USP14 proteasome inhibitor can penetrate the cell. purity: 99%
Apexbio Technology LLC 3'-O-Methyl-GTP 50ul (100 mM)
3 -O-Methyl-GTP is a methylated nucleotide analogue designed to serve as a chain terminator during RNA synthesis Structurally this molecule contains a methyl modification at the nucleotide s 3 -hydroxyl position enabling it to interact specifically with RNA polymerase active sites and subsequently pause or halt RNA polymerization Mechanistically its incorporation into nascent RNA transcripts prevents further phosphodiester bond formation thus interrupting RNA elongation Given these properties 3 -O-Methyl-GTP represents a useful tool for examining transcriptional regulation processes RNA polymerase function and investigating the molecular dynamics underlying RNA replication and transcription mechanisms Applications of this compound include biochemical assays molecular biology experiments and studies exploring the molecular pathways involved in RNA-related diseases
TARGETMOL CHEMICALS INC EVOBRUTINIB 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Evobrutinib(M2951) also known as M-2951 and MSC-2364447C is a highly selective inhibitor of the Bruton's tyrosine kinase (BTK) which is important in the development and functioning of various immune cells including B -lymphocytes and macrophages. PreClinical research suggests it may be therapeutically useful in certain autoimmune diseases. purity: 99%
TARGETMOL CHEMICALS INC BYK204165 25MG
Also available in 1 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BYK204165 (RT-017290) is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay)purity: 99%
AdipoGen L-2 4-Diaminobutyric acid 2HCl
Chemical. CAS 1883-09-6. Formula C4H10N2O2 . 2HCl. MW 118.1 . 72.9. Synthetic Unnatural amino acid derivative. Pharmacological tool and potential chiral building block used as an internal standard for amino acid analysis. Suitable reagent used for the differentiation of beta-N-methylamino-L-alanine from the diamino acids by using HPLC-FD, UHPLC-UV, UHPLC-MS, and triple quadrupole tandem mass spectrometry UHPLC-MS/MS. Used in the quantification of neurotoxin beta-N-methylamino-L-alanine BMAA in seafood. It has been found to inhibit GABA transaminase ABAT, producing elevated levels of GABA and to have an antitumor activity.
TARGETMOL CHEMICALS INC MITIPERSTAT 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Mitiperstat is a potent myeloperoxidase (MPO) inhibitor that is effective in preventing cardiovascular diseases such as heart failure and coronary artery disease. purity: 98%
TARGETMOL CHEMICALS INC GW806742X 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd 9.3 uM) with anti-necroptosis activity. GW806742X has activity against VEGFR2. purity: 99%
TARGETMOL CHEMICALS INC LXH254 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. LXH254 is a potent C-Raf and B-Raf inhibitor. purity: 99%
Medchemexpress LLC NPS 2390 | 226878-01-9 | 99.9% | 307.39 | 1 ML
NPS 2390 is a noncompetitive antagonist of mGluR1 and mGluR5. It is also identified as a potent inhibitor of CaSR (calcium-sensing receptor). This product is intended for research use only and is not sold to patients.
- Noncompetitive antagonist of mGluR1 and mGluR5.
- Potent CaSR (calcium-sensing receptor) inhibitor.
- Available in various quantities (5 mg, 10 mg, 25 mg, 50 mg, 100 mg solid; 10 mM * 1 mL in DMSO solution).
- High purity: 99.90%.
AdipoGen Methyl Green zinc Cl salt
Chemical. CAS 06.03.7114. Formula C27H35BrClN3 . ZnCl2. MW 653.24. Marker dye for DNA in acid and neutral media. Methyl green is mainly used as a DNA stain in histochemistry. At low concentrations it binds selectively to AT-rich regions of native DNA. At high concentrations it is present at all available DNA sites. Methyl Green is used as a tracking dye in acid buffers for electrophoresis. It helps differentiate bacteria and is also a tissue stain for nucleoli and mitochondria in tissues. Spectral data Absorption maxima = 630-635nm. May be used as a pH indicator with a pH range = pH 0.2yellow to pH 1.8blue.