Pyridazines and derivatives
Medchemexpress LLC Zardaverine | 101975-10-4 | C12H10F2N2O3 | 1 ML
Zardaverine is an orally active and selective PDE3/4 inhibitor with potent bronchodilator activity. It selectively inhibits the proliferation of HCC cells, inducing apoptosis and cell cycle arrest (G0/G1 phase). Zardaverine demonstrates good antitumor potential and is effective in bronchial relaxation and reducing inflammation in asthma.
- Targets phosphodiesterase (PDE) and apoptosis
- Pathway: Metabolic enzyme/protease and apoptosis
- Storage for powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 2 years, -20°C for 1 year
- Soluble in DMSO (25 mg/mL)
- Soluble in 10% DMSO, 40% PEG300, 5% Tween-80, 45% saline (≥ 2.08 mg/mL)
- Soluble in 10% DMSO, 90% corn oil (≥ 2.08 mg/mL)
- IC₅₀ target: PDE3, PDE4
eMolecules 1-BOC-1,2,3,6-TETRAHYDROPYRIDINE-4-CARBOXYLIC ACID | 70684-84-3 | MFCD02682417 | 1g
AstaTech | 1-BOC-1,2,3,6-TETRAHYDROPYRIDINE-4-CARBOXYLIC ACID | 1g | 449723662 | 30899 | 97.000 | 70684-84-3 | MFCD02682417 | 227.260 | C11H17NO4
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Medchemexpress LLC Zardaverine | 101975-10-4 | C12H10F2N2O3 | 50 MG
Zardaverine is an orally active and selective PDE3/4 inhibitor with IC50 values of 0.58 uM for PDE3 and 0.17 uM for PDE4. It exhibits potent bronchodilator activity and is effective in reducing inflammation in asthma. Zardaverine also shows antitumor potential by selectively inhibiting the proliferation of HCC cells, inducing apoptosis, and causing cell cycle arrest (G0/G1 phase).
- Orally active and selective PDE3/4 inhibitor
- Potent bronchodilator activity
- Effective in reducing inflammation in asthma
- Selectively inhibits proliferation of HCC cells
- Induces apoptosis and cell cycle arrest (G0/G1 phase)
- Antitumor potential
eMolecules (S)-2-METHOXYPROPAN-1-AMINE HCL | 907544-43-8 | MFCD18381951 | 1g
AstaTech | (S)-2-METHOXYPROPAN-1-AMINE HCL | 1g | 596576111 | 91001 | 95.000 | 907544-43-8 | MFCD18381951 | 125.600 | C4H12ClNO
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eMolecules (R)-8-METHYLCHROMAN-4-AMINE | 1213065-29-2 | MFCD07374029 | 1g
AstaTech | (R)-8-METHYLCHROMAN-4-AMINE | 1g | 448263276 | Y11839 | 95.000 | 1213065-29-2 | MFCD07374029 | 163.220 | C10H13NO
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eMolecules 1555847-27-2 | (4-METHOXYTETRAHYDRO-2H-PYRAN-4-YL)METHANAMINE HCL | MFCD26406717 | 1g
Medchem Express | MCL-1|BCL-2-IN-3 | 5mg | 506403963 | HY-129701 | 2163793-55-1 | 569.470 | C27H25BrN2O5S
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Cayman Chemical Phthalazinone pyrazole
A potent inhibitor of Aurora A kinase (IC50 = 31 nM); does not inhibit Aurora B kinase at doses up to 100 μM; inhibits the proliferation of HCT116, COLO 205, and MCF-7 cells (IC50 = 7.8, 2.9, and 1.6 μM, respectively)