Pyridines and derivatives
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- (1)
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- (7)
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- (34)
- (1)
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- (1)
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- (1)
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- (48)
- (1)
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- (1)
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Filtered Search Results
Promega Corporation SIRPALPHACD47 BLOCKADE BIOASS
PRJA6011 SIRPALPHACD47 BLOCKADE BIOASS
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Medchemexpress LLC Antiviral agent 24 | 23661-03-2 | C18H18F3N5O4 | 25 MG
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Antiviral agent 24 is a potent antiviral agent with EC50 values of 0.101, 19.9, and 91.2 μM for EV71, CVA21, and EV68, respectively. It inhibits METTL3/METTL14 activity in a dose-dependent manner. This product is for research use only.
- Potent antiviral agent
- Inhibits METTL3/METTL14 activity in a dose-dependent manner
- Purity: 99.63%
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Medchemexpress LLC Exendin-3/4 (64-86) | 98.29% | 2409.75 | 5 MG
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Exendin-3/4 (64-86) is a polypeptide derived from patent CN 106029087 A. The incretin receptor ligands are obtained from multiple skin toxicity Shan exosomes. This product appears as a white to off-white solid and is intended for research use only.
- Polypeptide sequence: EAVRLFIEWLKNGGPSSGAPPPS
- White to off-white solid appearance
- Intended for research use only
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Pen-N3 (PDZ peptide) | 98.8% | 1071.22 | 5 MG
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Pen-N3 is a PDZ peptide that inhibits Wnt/β-catenin signaling by recognizing dishevelled protein.
- Molecular weight: 1071.22
- Formula: C51H78N10O15
- Appearance: Solid
- Color: White to off-white
- Sequence: Glu-Ile-Val-Leu-Trp-Ser-Asp-Ile-Pro
- Sequence shortening: EIVLWSDIP
- Solubility in DMSO: 100 mg/mL (93.35 mM; needs ultrasonic; hygroscopic DMSO has a significant impact on product solubility, please use newly opened DMSO)
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Medchemexpress LLC (+)-JQ1 PA | 2115701-93-2 | 98.2% | 437.95 | 100 MG
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(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC50 of 10.4 nM. It functions as a click chemistry reagent, containing an Alkyne group, and is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that contain Azide groups.
- Functions as a derivative of a BET inhibitor.
- Exhibits an IC50 of 10.4 nM.
- Acts as a click chemistry reagent.
- Contains an alkyne functional group.
- Capable of copper-catalyzed azide-alkyne cycloaddition.
- Reacts with molecules containing azide groups.
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Apexbio Technology LLC GSK2292767 1254036-66-2 5mg
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GSK2292767 (CAS 1254036-66-2) is a potent and selective inhibitor of phosphoinositide 3-kinase delta (PI3K ) a lipid kinase involved in the regulation of cell growth proliferation differentiation and survival With a pKi of 10 1 GSK2292767 demonstrates over 100-fold selectivity for PI3K relative to other kinases in profiling assays In vitro studies show that it concentration-dependently inhibits IFN and IL-2 production in human lung parenchyma with pIC50 values of 8 7 and 8 5 respectively In vivo GSK2292767 reduces eosinophil recruitment in an acute OVA rat model (ED50 35 g/kg) and exhibits a favorable cardiovascular safety profile This compound is suitable for research on PI3K -mediated inflammatory respiratory diseases
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Medchemexpress LLC Notch 1 | 2408730-51-6 | 95.4% | 1500.72 | 5 MG
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Notch 1 (Notch homolog 1, translocation-associated) encodes a member of the NOTCH family of proteins. These Type I transmembrane proteins have an extracellular domain with multiple epidermal growth factor-like (EGF) repeats and an intracellular domain with multiple different domain types.
- Promotes mouse luminal prostate cell survival and proliferation by activating the prosurvival NF-κB pathway.
- Down-regulation reduces in vitro invasion and cell growth in human prostate cancer cell lines.
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Medchemexpress LLC Clec1b/clec-2 protein, human (recombinant, His-tag) | >80.0% | 100 UG
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Recombinant human CLEC1B/CLEC-2 protein (N-His) produced in HEK293 cells for research use. The protein is supplied in PBS, pH 7.4, with purity >80% and a reported molecular weight of 35-38 kDa; activity is characterized by functional ELISA. Intended for receptor-ligand studies, signaling assays, and antibody validation.
- Recombinant human CLEC1B/CLEC-2 protein with N-terminal His tag.
- Expressed in HEK293 mammalian cells.
- Includes amino acids Q58-P229 (accession Q9P126).
- Purity greater than 80% by reducing SDS-PAGE.
- Molecular weight 35-38 kDa.
- Formulated in PBS, pH 7.4, 0.22 μm filtered.
- Activity verified by functional ELISA.
- Store at -80°C; avoid repeated freeze-thaw cycles.
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Medchemexpress LLC Drak2-in-1 | 871837-60-4 | 99.9% | 10MM 1ML
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Drak2-in-1 | 871837-60-4 | 99.9% | 10MM 1ML
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Medchemexpress LLC Adenosylcobalamin | 13870-90-1 | 99.2% | 1579.58 | 1 ML
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Adenosylcobalamin (Coenzyme B12; Cobamamide; AdoCbl) is an active form of Vitamin B12 which is a cofactor for methylmalonyl CoA mutase.
- Serves as a cofactor for a group of enzymes that catalyze unusual rearrangement or elimination reactions.
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Medchemexpress LLC Amuvatinib (MP470) | 850879-09-3 | MFCD16038298 | 99.4% | 447.5 g/mol | C23H21N5O3S | 50 MG
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Amuvatinib is an orally bioavailable, multi-targeted receptor tyrosine kinase inhibitor and DNA repair suppressor used in preclinical research. It inhibits mutant c-Kit, PDGFRα, FLT3, c-Met, and c-Ret, and suppresses RAD51-mediated DNA repair; intended for research use only and not for human or clinical use.
- Orally bioavailable multi-targeted tyrosine kinase inhibitor.
- Inhibits mutant c-Kit, PDGFRα, FLT3, c-Met, and c-Ret.
- Suppresses RAD51-mediated DNA repair, exhibiting antineoplastic activity.
- Supplied as a research-grade chemical for laboratory applications.
- Reported molecular formula C23H21N5O3S and molecular weight 447.5 g/mol.
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Medchemexpress LLC 123B9 | 2225868-19-7 | 99.7% | 1321.79 | 5 MG
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123B9 is a tumor-homing agent that acts as a potent and selective EphA2 agonist with a Kd value of 4.0 μM. It selectively targets the EphA2 tyrosine kinase receptor ligand-binding domain and does not significantly inhibit the ligand binding domains of the closely related EphA3 and EphA4 receptors.
- Potent and selective EphA2 agonist
- Tumor-homing agent
- Selectively targets the EphA2 tyrosine kinase receptor ligand-binding domain
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Medchemexpress LLC Papain inhibitor (Glycylglycyl-L-tyrosyl-L-arginine) | 70195-20-9 | 99.6% | 451.48 | 100 MG
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Papain inhibitor (Glycylglycyl-L-tyrosyl-L-arginine) acts as an effective competitive inhibitor to papain, with a Ki of 9 μM at pH 6.2. This high-purity chemical is suitable for research use.
- Effective competitive inhibitor to papain.
- Ki of 9 μM at pH 6.2.
- Available in various quantities (10 mg, 25 mg, 50 mg, 100 mg).
- High purity (99.60%).
- For research use only.
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Medchemexpress LLC Indobufen | 63610-08-2 | 99.98% | 295.33 | 50 MG
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Indobufen is a platelet aggregation inhibitor and a reversible platelet cyclooxygenase (Cox) activity inhibitor. It suppresses thromboxane A2 (TxA2) synthesis and down-regulates tissue factor (TF) in monocytes. This compound is intended for research and analytical applications, serving as a reference standard for assays and is commonly utilized in qualitative, quantitative, and methodological research experiments.
- Platelet aggregation inhibitor
- Reversible platelet cyclooxygenase (Cox) activity inhibitor
- Suppresses thromboxane A2 (TxA2) synthesis
- Down-regulates tissue factor (TF) in monocytes
- Analytical standard for research applications
- Suitable for HPLC, GC, and MS experiments
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Medchemexpress LLC JNJ-28583113 | 2765255-93-2 | 98.8% | 366.38 | 25 MG
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JNJ-28583113 is a brain-permeable TRPM2 antagonist. It inhibits TRPM2-blocked phosphorylation of GSK3α and β subunits, protecting cells from oxidative stress-induced cell death and suppressing cytokine release in response to pro-inflammatory stimuli in microglia.
- Inhibits TRPM2 in cells overexpressing chimpanzee, rat, and human TRPM2.
- Prevents cells from H2O2 induced cell death.
- Protects HeLa cells from H2O2 induced morphological changes.
- Achieves 400 ng/mL in the brain compartment.
- Quickly metabolized in plasma.
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