Pyrroles
Selleck Chemical LLC Atorvastatin
Atorvastatin is a lipid lowering agent It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway Atorvastatin activates autophagy
Apexbio Technology LLC AHU-377 hemicalcium salt 1369773-39-6 100mg
AHU-377 hemicalcium salt (CAS 1369773-39-6) is a hemicalcium salt form of AHU-377 a potent inhibitor of neprilysin (neutral endopeptidase) with an IC50 of 5 nM As a prodrug AHU-377 is enzymatically converted to its active metabolite LBQ657 following ester cleavage AHU-377 is a key component of LCZ696 co-formulated with valsartan at a 1 1 molar ratio functioning as an angiotensin receptor neprilysin inhibitor (ARNI) In vivo studies demonstrate that oral administration of AHU-377 induces dose-dependent blood pressure reduction in DAHI-SS rats though it has less pronounced effects in DOCA-salt hypertensive models AHU-377 is widely studied in cardiovascular research particularly in the context of heart failure and hypertension
Selleck Chemical LLC Vicriviroc Malate S2004-25mg
Vicriviroc is a potent CCR5 antagonist with IC50 of 0 91 nM showing broad-spectrum activity against genetically diverse HIV-1 isolates and also drug-resistant viruses with RTI PRI or MDR phenotypes Phase 3
Medchemexpress LLC (-)-Corey lactone benzoate | 39746-00-4 | 98.0% | 276.28 | 500 MG
(-)-Corey lactone benzoate is a building block used in the chemical synthesis of corey aldehyde.
- Used as a building block in chemical synthesis
Cayman Chemical SBromoenol lactone
A selective iPLA2β inhibitor; inhibits vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells (IC50 = 2 µM); >1,000-fold selective for iPLA2 versus cPLA2 and 10-fold selective for iPLA2β versus iPLA2γ
Apexbio Technology LLC Sunitinib malate(Synonyms: Sutent, SU11248, Sunitinib L-malate, Sunitinib malate salt, SU-11248 malate, Sutent malate), 100mg, CAS: 341031-54-7.
Sunitinib malate (CAS 341031-54-7) is a small molecule orally bioavailable multitargeted receptor tyrosine kinase inhibitor It inhibits various receptor tyrosine kinases including platelet-derived growth factor receptor (PDGFR) vascular endothelial growth factor receptors (VEGFR-1 2 and 3) c-KIT FLT3 kinase colony-stimulating factor-1 receptor (CSF-1R) and RET kinase In neuroblastoma cell lines (e g SK-N-BE(2) SH-SY5Y LAN-5) treatment with sunitinib malate significantly suppresses proliferation in a dose-dependent manner (IC50 10-20 ng/ml) Preclinical studies show tumor growth inhibition and reduced metastasis in neuroblastoma mouse models highlighting its potential for research in oncology therapeutics
Apexbio Technology LLC Pizotifen Malate 5189-11-7 500mg
Pizotifen malate (CAS 5189-11-7) is a benzocycloheptane derivative that functions as a potent antagonist of serotonin (5-HT) receptors exhibiting high selectivity for this target class By inhibiting serotonergic neurotransmission Pizotifen malate is utilized in biomedical research to investigate the physiological and pharmacological roles of 5-HT pathways Its receptor blocking properties enable studies focused on serotonergic modulation migraine mechanisms and disorders associated with altered serotonin signaling
Cayman Chemical NhexanoylLHomoserine lactone
A bacterial quorum sensing signal molecule; regulates virulence in general and in cystic fibrosis, infection prevention, slime and biofilm reduction in commercial agriculture and aquaculture industries, food spoilage prevention, and septicemia in fish
Medchemexpress LLC Atorvastatin hemicalcium | 134523-03-8 | 99.94% | 577.67 | 1 ML
Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. It is capable of penetrating the blood-brain barrier and effectively reduces blood lipids. This compound inhibits human SV-SMC proliferation and invasion, and decreases apoptosis of myocardial cells by down-regulating specific proteins. It also activates endoplasmic reticulum (ER) stress in response to heart failure and angiotensin II (Ang II) stimulation. This product is for research use only.
- Orally active HMG-CoA reductase inhibitor
- Penetrates the blood-brain barrier
- Effectively reduces blood lipids
- Inhibits human SV-SMC proliferation and invasion
- Decreases myocardial cell apoptosis
- Activates endoplasmic reticulum (ER) stress response
- Reduces ER stress signaling proteins
- Inhibits proinflammatory cytokines
Cayman Chemical NoctanoylLHomoserine lactone
A small diffusible signaling molecule involoved in quorum sensing, controlling gene expression, and affecting cellular metabolism; applications of this molecule include infection prevention and a regulation of virulence in general and in cystic fibrosis
Medchemexpress LLC (-)-Corey lactone diol | 32233-40-2 | 172.18 | 10 G
(-)-Corey lactone diol is the reduced form of Corey aldehyde, serving as a versatile drug intermediate. It is commonly used in the synthesis of compounds such as Beraprost.
- Reduced form of Corey aldehyde
- Used as a drug intermediate for synthesis
- Appears as a solid
- Purity 98.0%
- White to off-white appearance
- Stable under recommended storage conditions
- For research use only
TARGETMOL CHEMICALS INC Sacubitril hemicalcium salt
Also available in 1 mL, 2 mg, 5 mg, 10 mg, 25 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Sacubitril hemicalcium salt (AHU377 calcium salt) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696. Sacubitril hemicalcium salt is a prodrug of LBQ657, which is an inhibitor of the zinc metallopeptidase neprilysin. Neprilysin degrades a variety of vasoactive peptides such as atrial and brain natriuretic peptide, bradykinin, adrenomedullin, and endothelin-1. Inhibition of neprilysin leads to an increased level of these peptides and, thus, antihypertensive effects. Formulations containing AHU377 in combination with the angiotensin II receptor antagonist valsartan are used to treat hypertension and heart failure. Purity 99.93%