Pyrroles
Medchemexpress LLC (3S,5S)-Atorvastatin | 501121-34-2 | 95.0% | 100 MG
(3S,5S)-Atorvastatin is an inactive enantiomer of Atorvastatin and can activate the pregnane X receptor (PXR). Atorvastatin is an orally active HMG-CoA reductase inhibitor that effectively decreases blood lipids.
- (3S,5S)-Atorvastatin increases CYP2B and CYP3A mRNA content with equal ability as atorvastatin.
- It induces luciferase activity with an EC50 of 12.4 μM at 100 μM concentrations.
- The addition of (3S,5S)-Atorvastatin to a 2-formylphenylboronic acid (FPBA)/l-tryptophanol mixture enhances the intensity of l-tryptophanol fluorescence.
Medchemexpress LLC Atorvastatin hemicalcium trihydrate | 344920-08-7 | 99.70% | 50 MG
Atorvastatin hemicalcium trihydrate is an orally active HMG-CoA reductase inhibitor that effectively decreases blood lipids. It inhibits human SV-SMC proliferation and invasion. This compound is known to reduce apoptosis of myocardial cells and activate endoplasmic reticulum stress response, making it suitable for various research applications.
- Orally active HMG-CoA reductase inhibitor
- Effectively decreases blood lipids
- Inhibits human SV-SMC proliferation and invasion
- Reduces apoptosis of myocardial cells
- Activates endoplasmic reticulum stress response
- Inhibits proinflammatory cytokines
AdipoGen Sunitinib . malate (5 mg)
Chemical. CAS: 341031-54-7. Formula: C22H27FN4O2 . C4H6O5. MW: 398.5 . 134.1. Potent ATP-competitive and cell permeable multi-targeted receptor tyrosine kinase (RTK) inhibitor targeting VEGFR and PDGFR-beta. Inhibits FLK1 (Ki=9nM), PDGFRbeta (Ki=8nM) and FLT3. It is at least 10-fold selective for FLK1 and PDGFRbeta over a variety of tyrosine kinases in a panel, including EGFR, Cdk2, Met, IGFR-1, Abl and Src. Inhibits the cellular receptor phosphorylation of FLT3, RET and CSF-1R. Also shown to inhibit c-Kit. Exhibits potent antiangiogenic and antitumor activity in multiple xenograft models.
Medchemexpress LLC Atorvastatin hemicalcium salt | 134523-03-8 | 99.9% | 577.67 | 200 MG
Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, with blood-brain barrier permeability. It has the ability to effectively decrease blood lipids. This compound inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.
- Orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.
- Possesses blood-brain barrier permeability.
- Effectively decreases blood lipids.
- Inhibits human SV-SMC proliferation and invasion.
Medchemexpress LLC (-)-G-Lactone | 43119-28-4 | ≥98.0% | 124.14 | 10 G
(-)-G-Lactone is a synthetic intermediate useful for prostaglandins synthesis. It is for research use only and not sold to patients.
- Appears as a solid
- Color is off-white to light yellow
- Store at room temperature for 3 years
- In solvent: -80°C for 2 years, -20°C for 1 year
Cayman Chemical 4-hydroxy Atorvastatin lacton
A metabolite of atorvastatin; formed by metabolism of atorvastatin by CYP3A4
Medchemexpress LLC (-)-Corey lactone diol | 32233-40-2 | 172.18 | 500 MG
(-)-Corey lactone diol is an analytical standard and pharmaceutical intermediate. It is the reduced form of Corey aldehyde and serves as a building block in chemical synthesis. This product is intended for research and analytical applications, including use as a reference standard in HPLC, GC, and MS for qualitative, quantitative, and methodological research.
- Analytical standard for research and analytical applications
- Reduced form of corey aldehyde
- Pharmaceutical intermediate in synthesis
- Reference standard in HPLC, GC, and MS studies
- Building block in chemical synthesis
- Suitable as a laboratory chemical
Medchemexpress LLC Nemonoxacin malate | 951163-60-3 | 99.3% | 505.52 | 10 MG
Nemonoxacin malate is a nonfluorinated quinolone antibiotic with broad-spectrum activity against Gram-positive, Gram-negative, and atypical pathogens. It can inhibit drug-resistant *Streptococcus pneumoniae* and Methicillin-resistant *Staphylococcus aureus*, and is used for research of community-acquired pneumonia. In vitro, it shows antibacterial activity against *Chlamydia pneumoniae* with MIC90s of 0.06 μg/mL, and is highly active against community-acquired MRSA (CA-MRSA).
- Nonfluorinated quinolone antibiotic
- Broad-spectrum activity against Gram-positive, Gram-negative, and atypical pathogens
- Inhibits drug-resistant *Streptococcus pneumoniae*
- Inhibits Methicillin-resistant *Staphylococcus aureus*
- Used for research of community-acquired pneumonia
- Antibacterial activity against *Chlamydia pneumoniae*
- Highly active against community-acquired MRSA (CA-MRSA)
Apexbio Technology LLC Atorvastatin Calcium 134523-03-8 50mg
Atorvastatin Calcium (CAS 134523-03-8) is a selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase the rate-limiting enzyme involved in cholesterol biosynthesis By targeting this enzyme atorvastatin reduces intracellular cholesterol production thereby stimulating hepatic expression of low-density lipoprotein (LDL) receptors and facilitating plasma LDL clearance Atorvastatin exhibits an IC50 of approximately 154 nM against HMG-CoA reductase Clinically atorvastatin decreases total cholesterol and LDL levels applicable to research models of hypercholesterolemia and cardiovascular disease including studies on lipid metabolism and atherosclerosis pathogenesis
Medchemexpress LLC Atorvastatin lactone | 125995-03-1 | MFCD00899262 | 96.7% | 540.62 g·mol⁻1 | C33H33FN2O4 | 10 MG
Atorvastatin lactone is the lactone (prodrug) form of atorvastatin, an HMG-CoA reductase inhibitor used in research to investigate statin metabolism, enzyme inhibition, and lipid regulation. The material is supplied as a purified solid suitable for biochemical and analytical applications, enabling metabolism studies and assay development.
- Prodrug form of atorvastatin for metabolic studies.
- Useful for HMG-CoA reductase inhibition assays.
- Provided as a purified solid with reported purity of 96.7%.
- Suitable as an analytical standard and research reagent.
- Stable under typical laboratory storage conditions.
Medchemexpress LLC Atorvastatin epoxy tetrahydrofuran impurity | 873950-19-7 | 449.47 | 25 MG
Atorvastatin Epoxy Tetrahydrofuran Impurity is an impurity isolated oxidative degradation product of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, which has the ability to effectively decrease blood lipids. Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction. The endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation.
- Impurity isolated oxidative degradation product
- Orally active HMG-CoA reductase inhibitor
- Effectively decreases blood lipids
- Decreases apoptosis of myocardial cells
- Down-regulates GRP78, caspase-12 and CHOP expression