Pyrroles
Selleck Chemical LLC Sunitinib
Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFR with IC50 of 80 nM and 2 nM and also inhibits c-Kit Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1 Sunitinib induces autophagy and apoptosis
AdipoGen Sunitinib . malate (500 mg)
Chemical. CAS: 341031-54-7. Formula: C22H27FN4O2 . C4H6O5. MW: 398.5 . 134.1. Potent ATP-competitive and cell permeable multi-targeted receptor tyrosine kinase (RTK) inhibitor targeting VEGFR and PDGFR-beta. Inhibits FLK1 (Ki=9nM), PDGFRbeta (Ki=8nM) and FLT3. It is at least 10-fold selective for FLK1 and PDGFRbeta over a variety of tyrosine kinases in a panel, including EGFR, Cdk2, Met, IGFR-1, Abl and Src. Inhibits the cellular receptor phosphorylation of FLT3, RET and CSF-1R. Also shown to inhibit c-Kit. Exhibits potent antiangiogenic and antitumor activity in multiple xenograft models.
Medchemexpress LLC Pha-665752 | 477575-56-7 | MFCD18632554; MFCD07772270 | 99.9% | 641.61 g/mol | C32H34Cl2N4O4S | 5 MG
PHA-665752 is a selective, ATP-competitive inhibitor of the c-Met (HGFR) receptor tyrosine kinase used in preclinical research to induce apoptosis, cause cell-cycle arrest, and reduce tumor growth in vitro and in vivo. It demonstrates high potency and selectivity versus other kinases and is supplied for research use only.
- Selective ATP-competitive c-Met inhibitor with Ki ≈ 4 nM and IC50 ≈ 9 nM.
- High purity solid (approximately 99.9%) suitable for biochemical assays.
- Molecular formula C32H34Cl2N4O4S; molecular weight 641.61 g/mol.
- Storage: powder at -20°C for long term; in solution store at -80°C when possible.
- Supplied in small preweighed milligram quantities for laboratory research.
Selleck Chemical LLC Atorvastatin
Atorvastatin is a lipid lowering agent It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway Atorvastatin activates autophagy
Aobchem 1-N-BOC-pyrrole-2-boronic acid, AOBCHEM USA 12234-25G. 135884-31-0. MFCD01318939
1-N-BOC-pyrrole-2-boronic acid, AOBCHEM USA 12234-25G. 135884-31-0. MFCD01318939