Pyrroles
AdipoGen Sunitinib . malate (500 mg)
Chemical. CAS: 341031-54-7. Formula: C22H27FN4O2 . C4H6O5. MW: 398.5 . 134.1. Potent ATP-competitive and cell permeable multi-targeted receptor tyrosine kinase (RTK) inhibitor targeting VEGFR and PDGFR-beta. Inhibits FLK1 (Ki=9nM), PDGFRbeta (Ki=8nM) and FLT3. It is at least 10-fold selective for FLK1 and PDGFRbeta over a variety of tyrosine kinases in a panel, including EGFR, Cdk2, Met, IGFR-1, Abl and Src. Inhibits the cellular receptor phosphorylation of FLT3, RET and CSF-1R. Also shown to inhibit c-Kit. Exhibits potent antiangiogenic and antitumor activity in multiple xenograft models.
Medchemexpress LLC Atorvastatin hemicalcium salt | 134523-03-8 | MFCD00078759 | 99.9% | 1155.37 | 100 MG
Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor with blood-brain barrier permeability. It is effective in decreasing blood lipids. The compound inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.
- Orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.
- Possesses blood-brain barrier permeability.
- Effectively decreases blood lipids.
- Inhibits human SV-SMC proliferation and invasion.
Cayman Chemical Atorvastatin calcium salt hy
An HMG-CoA reductase inhibitor (IC50s = 73, 102, and 0.6 nM for HepG2 cells, human fibroblasts, and rat hepatocytes, respectively)
Cayman Chemical NbutyrylLHomoserine lactone
A bacterial quorum sensing signal molecule; regulates virulence in general, infection prevention, and formation of biofilms
Cayman Chemical Atorvastatin calcium salt hy
An HMG-CoA reductase inhibitor (IC50s = 73, 102, and 0.6 nM for HepG2 cells, human fibroblasts, and rat hepatocytes, respectively)