Pyrrolidines
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Medchemexpress LLC (1R,2S)-VU0155041 | 1263273-14-8 | 95.1% | C14H15Cl2NO3 | 25 MG
(1R,2S)-VU0155041 is a cis regioisomer of VU0155041 that functions as a partial mGluR4 agonist with an EC50 of 2.35 μM. It demonstrates selectivity for mGluR4 over 67 other targets and does not affect striatal NMDA receptor function. This compound is soluble in an aqueous vehicle and reduces haloperidol-induced catalepsy and reserpine-induced akinesia in rats.
- Acts as a partial mGluR4 agonist
- Similar potency at human and rat mGluR4 receptors
- Induces concentration-dependent shifts in baseline in thallium flux assays
- Activates the receptor through a site distinct from the glutamate binding site
- Exhibits selectivity for mGluR4 over 67 other targets
- Does not affect striatal NMDA receptor function
- Soluble in an aqueous vehicle
- Reduces haloperidol-induced catalepsy and reserpine-induced akinesia in rats
