Quinolines and derivatives
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Filtered Search Results
Apexbio Technology LLC STF 31 724741-75-7 50mg
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STF 31 (CAS 724741-75-7) is a small-molecule inhibitor targeting glucose transporter 1 (GLUT1) with an IC50 of 1 M By antagonizing GLUT1 STF 31 disrupts glucose uptake selectively impairing survival in VHL-deficient renal cell carcinoma (RCC) models that depend on enhanced glycolysis In vitro STF 31 exhibits selective cytotoxicity toward VHL-deficient RCC4 cells while exerting minimal effects on RCC4/VHL controls In vivo administration of STF 31 analogs retards tumor growth in VHL-deficient RCC xenografts without notable toxicity in mice STF 31 is utilized in research to investigate GLUT1-mediated metabolic dependencies and therapeutic vulnerabilities in cancer and neuroinflammatory models
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000428337 SULFO-CY3 AMINE 25MG
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eMolecules AZIDO-PEG2-AMINE 5G
5000169277 AZIDO-PEG2-AMINE 5G
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Medchemexpress LLC Mefloquine (Standard) | 53230-10-7 | MFCD00869324 | 378.31 | 100 MG
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Mefloquine (Standard) is the analytical standard of Mefloquine, intended for research and analytical applications. It is an orally active and potent quinoline antimalarial agent and an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. This analytical standard grade compound is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Orally active and potent quinoline antimalarial agent.
- Anti-SARS-CoV-2 entry inhibitor.
- K+ channel (KvQT1/minK) antagonist.
- Used for malaria, systemic lupus erythematosus, and cancer research.
- Analytical standard grade for qualitative, quantitative, and methodological research experiments.
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Medchemexpress LLC Pomalidomide-amido-C3-COOH | 2162120-77-4 | 99.5% | 387.34 | 100 MG
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Pomalidomide-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker used in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Pomalidomide-based cereblon ligand
- Linker used in PROTAC technology
- Intended for research use only
- Solid appearance
- White to light yellow color
- Stable under recommended storage conditions
- Used in cancer and cancer targeted therapy research
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Apexbio Technology LLC NPS-2143 284035-33-2 200mg
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NPS-2143 (CAS 284035-33-2) is a selective antagonist of the calcium-sensing receptor (CaSR) It attenuates the sensitivity of CaSR to extracellular calcium ([Ca2 ]o) thereby modulating downstream signaling and promoting parathyroid hormone (PTH) secretion in vivo In vitro studies demonstrate that NPS-2143 inhibits [Ca2 ]o-induced intracellular calcium signaling in HEK 293T cells expressing CaSR with an EC50 of 4 27 mM for the wild-type receptor It also reduces excessive signal transduction in cells expressing various activating CaSR mutations NPS-2143 is widely utilized in research investigating CaSR function calcium homeostasis and the pharmacological modulation of parathyroid hormone regulation
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000377241 KRAS INHIBITOR-31 50MG
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Cayman Chemical 8 12isoiPF2aVI1 5lactone
A racemic mixture of the lactone form of the free acid, 8,12-iso- iPF2α-VI; the free acid is the most abundant F2-iP2 regioisomer measured in the urine of rats treated to induce lipid peroxidation; used as a biomarker for oxidative stress
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000428318 ACRIDINE ORANGE 10-N 100MG
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eMolecules 7-BROMOQUINOLINE 1G
5000224212 7-BROMOQUINOLINE 1G
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Medchemexpress LLC Lobeglitazone (sulfate) | 763108-62-9 | 99.6% | 578.61 | 50 MG
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Lobeglitazone sulfate is a new type of thiazolidinedione and an orally active agonist for PPAR with EC50 of 137.4 nM and 546.3 nM for PPARγ and PPARα. It is an inhibitor for the ERK/JNK/Smad/NF-κB signaling pathway and exhibits anti-inflammatory, anti-diabetic, anti-fibrotic, and anti-atherosclerotic properties.
- Orally active agonist for PPAR.
- Inhibits the ERK/JNK/Smad/NF-κB signaling pathway.
- Exhibits anti-inflammatory properties.
- Possesses anti-diabetic properties.
- Demonstrates anti-fibrotic and anti-atherosclerotic properties.
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Medchemexpress LLC 7-Azaindazole | 271-73-8 | 119.12 | 10 G
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7-Azaindazole is a biochemical reagent that serves as a versatile building block in chemical synthesis. It can be used as a biological material or organic compound for life science related research.
- Used as a ligand for ruthenium (Ru) complexes as a potential anticancer agent.
- Used for the synthesis of various derivatives for numerous applications, such as anticancer and antiviral studies.
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Apexbio Technology LLC RU.521 2262452-06-0 10mg
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RU 521 (CAS 2262452-06-0) is a selective inhibitor of cyclic GMP-AMP synthase (cGAS) an enzyme responsible for synthesizing cGAMP upon recognition of cytosolic double-stranded DNA By interfering with cGAS-mediated cGAMP production RU 521 suppresses activation of the type I interferon signaling pathway Experimental studies demonstrate that RU 521 reduces cGAS-dependent signal transduction and interferon responses in reporter assays containing double-stranded DNA In macrophages derived from Aicardi-Gouti res syndrome mouse models RU 521 lowers basal interferon expression This compound is a valuable tool for investigating cGAS-dependent innate immune pathways
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Medchemexpress LLC 7-Nitroindazole | 2942-42-9 | 99.1% | C7H5N3O2 | 200 MG
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7-Nitroindazole | 2942-42-9 | 99.1% | C7H5N3O2 | 200 MG
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eMolecules METHYL 2-QUINOLIN-6-YLAC 25G
5000159857 METHYL 2-QUINOLIN-6-YLAC 25G
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