Quinolines and derivatives

Apexbio Technology LLC AM-095 free base 1228690-36-5 200mg

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AM-095 free base (CAS 1228690-36-5) is an orally bioavailable antagonist of lysophosphatidic acid receptor 1 (LPA1) It demonstrates inhibitory activity against recombinant human and mouse LPA1 with IC50 values of 0 98 M and 0 73 M respectively In vitro AM-095 suppresses LPA1-mediated chemotaxis in both mouse LPA1/CHO cells (IC50 0 78 M) and human A2058 melanoma cells (IC50 0 23 M) In murine models it blocks LPA-induced histamine release and reduces collagen and protein levels in bronchoalveolar lavage fluid with ED50 values of 8 3 mg/kg and 10 mg/kg respectively Additionally AM-095 decreases macrophage and lymphocyte infiltration in bleomycin-induced lung injury models supporting its utility in studies of LPA1-mediated fibrotic and inflammatory processes

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Cambridge Isotope Laboratories CGA 580 / 3L carbon steel cylinder packless brass angle ea

CGA 580 / 3L carbon steel cylinder packless brass angle ea

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Medchemexpress LLC Anthra[1,9-cd]pyrazol-6(2H)-one | 129-56-6 | 99.7% | 200 MG

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SP600125 is a reversible, ATP-competitive inhibitor of c-Jun N-terminal kinases (JNK1, JNK2, JNK3) used as a research reagent. Reported IC50 values are 40 nM for JNK1, 40 nM for JNK2, and 90 nM for JNK3. The compound has also been reported to inhibit ferroptosis and to induce conversion from autophagy to apoptosis in certain cancer cells.

• ATP-competitive inhibitor of JNK1, JNK2, and JNK3.
• IC50 values: 40 nM (JNK1), 40 nM (JNK2), 90 nM (JNK3).
• High purity (99.73%).
• Available as a 200 MG pack for research and analytical use.
• Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (2 years) or -20°C (1 year).
• Intended for research use only.

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Medchemexpress LLC Cinchonidine | 485-71-2 | 99.6% | 294.39 | 10 G

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Cinchonidine (α-Quinidine) is a cinchona alkaloid found in *Cinchona officinalis* and *Gongronema latifolium*. It is a building block used in asymmetric synthesis in organic chemistry. It acts as a weak inhibitor of serotonin transporter (SERT) and exhibits antimalarial activities.

• Source: Cinchona alkaloid found in *Cinchona officinalis* and *Gongronema latifolium*.
• Application: Building block in asymmetric synthesis in organic chemistry.
• Biological activity: Weak inhibitor of serotonin transporter (SERT).
• Pharmacological effect: Antimalarial activities.
• Appearance: Solid, white to off-white.
• Storage: Room temperature for continental US shipping; 4°C, protected from light, stored under nitrogen.

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Medchemexpress LLC MEDCHEMEXPRESS LLC

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5000427441 BETULIN 200MG

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eMolecules​ 7-HYDROXYQUINOLINE-6-CARBOX 1G

5000225136 7-HYDROXYQUINOLINE-6-CARBOX 1G

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Medchemexpress LLC MEDCHEMEXPRESS LLC

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5000370629 SCH900776 200MG

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Apexbio Technology LLC Proflavine Hemisulfate 1811-28-5 10mM (in 1mL DMSO)

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Proflavine Hemisulfate (CAS 1811-28-5) is a small-molecule inhibitor targeting DNA It is designed to intercalate into DNA strands thereby disrupting DNA replication and transcription Proflavine Hemisulfate exerts its biological activity primarily through DNA intercalation In in vitro studies Proflavine Hemisulfate demonstrates antimicrobial activity with reported IC50 values for inhibiting bacterial growth typically ranging between 1 10 M depending on the microbial strain and assay conditions used Based on these pharmacological properties Proflavine Hemisulfate holds research potential in studies of antimicrobial activity DNA replication assays mutagenesis and evaluating sensitivity and resistance profiles of microorganisms

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eMolecules​ 2,4-Quinolinediol monosodium salt | 4510-76-3 | MFCD00078382 | 1g

Combi-Blocks | 2,4-Quinolinediol monosodium salt | 1g | 448009166 | QC-9161 | 97.000 | 4510-76-3 | MFCD00078382 | 183.142 | C9H6NNaO2

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Medchemexpress LLC MEDCHEMEXPRESS LLC

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