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Filtered Search Results
Medchemexpress LLC Amino-PEG3-C2-sulfonic acid | 1817735-43-5 | 99.5% | 257.30 | 50 MG
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Amino-PEG3-C2-sulfonic acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are molecules containing two ligands connected by a linker: one for an E3 ubiquitin ligase and another for the target protein. Their application involves exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Applicable in cancer and cancer targeted therapy
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Medchemexpress LLC Mexenone | 1641-17-4 | 99.9% | 200 MG
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Mexenone is a potent benzophenone-type UV filter used as a sunscreening agent.
- Potent benzophenone-type UV filter.
- Used for sunscreening.
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Medchemexpress LLC MCC950 | 210826-40-7 | 99.8% | 200 MG
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MCC950 is a potent and selective NLRP3 inhibitor, with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs. It blocks canonical and non-canonical NLRP3 activation at nanomolar concentrations. This product is for research use only.
- Potent and selective NLRP3 inhibitor
- Blocks canonical and non-canonical NLRP3 activation
- Specifically inhibits NLRP3, not AIM2, NLRC4, or NLRP1
- Reduces interleukin-1β (IL-1β) production
- Attenuates the severity of experimental autoimmune encephalomyelitis (EAE)
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Ambeed Methyl 5bromo6oxo1 6dihydropyr
Methyl 5-bromo-6-oxo-1,6-dihydropyridine-2-carboxylate, 178876-86-3, 98%
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TARGETMOL CHEMICALS INC Monocrotaline 200MG
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Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Monocrotaline (Crotaline) is a pyrrolizidine alkaloid extracted from the seeds of the Crotalaria plant. Monocrotaline has certain cellular activity against HepG2 cells and can induce pulmonary hypertension in rodents. Purity 99.59%
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Medchemexpress LLC Phenmedipham | 13684-63-4 | 98.38% | 200 MG
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Phenmedipham is a carbamate herbicide. It is for research use only and not sold to patients.
- Carbamate herbicide
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Apexbio Technology LLC Cy5.5 alkyne (non-sulfonated) 50mg
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Cy5 5 alkyne non-sulfonated is a near-infrared fluorescent cyanine derivative equipped with an alkyne functional group for click chemistry applications Through copper-catalyzed azide-alkyne cycloaddition (CuAAC) it forms covalent conjugates with azide-containing biomolecules metabolites or small-molecule ligands Cy5 5 alkyne non-sulfonated is primarily soluble in organic solvents aqueous solutions containing organic co-solvent such as DMSO may be used during conjugation Based on these chemical properties Cy5 5 alkyne non-sulfonated holds research potential in labeling nucleic acids peptides proteins lipids and other biomolecules for biomedical imaging tissue distribution evaluation and related pharmaceutical research applications
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Apexbio Technology LLC Belinostat (PXD101) 414864-00-9 200mg
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Belinostat (PXD101) is a hydroxamic acid-based inhibitor targeting histone deacetylase (HDAC) enzymes Its mechanism involves the suppression of HDAC enzymatic activity leading to increased acetylation of histone proteins H3 and H4 within cells In biochemical assays using Hela cell extracts belinostat exhibits inhibitory activity against HDAC with an IC50 value of approximately 27 nM In tumor cell culture models belinostat induces cytotoxicity and represses cellular proliferation with reported IC50 values ranging roughly from 0 5 M to 10 M varying by cell type and origin making it suitable for research on epigenetic modulation in oncology specifically in studies of bladder prostate and related cancer cell lines
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TARGETMOL CHEMICALS INC ASTX660 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ASTX660 is an orally bioavailable dual antagonist of cIAP and XIAP. purity: 99%
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eMolecules 6-BROMO-3-QUINOLINOL | 552330-94-6 | MFCD09260430 | 5g
AstaTech | 6-BROMO-3-QUINOLINOL | 5g | 213339936 | 83287 | 95.000 | 552330-94-6 | MFCD09260430 | 224.057 | C9H6BrNO
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eMolecules Building Block Tool
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Medchemexpress LLC Azatadine (dimaleate) | 3978-86-7 | 99.85% | 200 MG
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Azatadine dimaleate is an inhibitor of histamine and cholinergic with an IC50 of 6. It also exhibits antiserotonin activity and can be used in research on perennial allergic rhinitis.
- Inhibitor of histamine and cholinergic
- Exhibits antiserotonin activity
- Can be studied in research on perennial allergic rhinitis
- Targets histamine receptor
- Involves GPCR/G protein, immunology/inflammation, and neuronal signaling pathways
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Apexbio Technology LLC Carboxine 5234-68-4 200mg
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Carboxine (5234-68-4) is a small-molecule inhibitor targeting mitochondrial succinate dehydrogenase (SDH) It is designed to inhibit SDH activity thereby interfering with fungal cellular respiration pathways Carboxine exerts its biological activity primarily through inhibition of mitochondrial SDH In in vitro studies Carboxine demonstrates inhibitory efficacy with IC50 values typically in a micromolar range depending on fungal species and assay conditions Based on these pharmacological properties Carboxine holds research potential in studying mitochondrial metabolism energy production pathways fungicidal resistance mechanisms and assessment of biochemical impacts of SDH inhibition within fungal cells
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TARGETMOL CHEMICALS INC Cefaclor monohydrate 200MG
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Also available in 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Cefaclor monohydrate (Cefaclorum) is a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Purity 99.48%
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Apexbio Technology LLC A-966492 934162-61-5 200mg
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A-966492 (CAS 934162-61-5) is a potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) exhibiting a Ki of 1 nM It also inhibits PARP-2 with a Ki of approximately 1 5 nM As a PARP inhibitor this compound interferes with the enzymatic activity essential for DNA repair pathways sensitizing cancer cells to cytotoxic therapies In vitro A-966492 shows effective inhibition in C41 cells with an EC50 of 1 nM and demonstrates moderate oral bioavailability (34-72%) and a half-life of around 1 7-1 9 hours It crosses the blood-brain barrier and has demonstrated activity in preclinical murine cancer models including B16F10 melanoma and BRCA1-deficient MX-1 breast cancer xenografts enhancing the efficacy of chemotherapeutic agents such as temozolomide and carboplatin
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TARGETMOL CHEMICALS INC Scopoletin 200MG
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Also available in 1 mL, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Scopoletin (Esculetin 6-methyl ether) is a plant growth factor derived from the root of Scopolia carniolica, inhibits of acetylcholinesterase (AChE). Purity 99.88%
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