Quinolines and derivatives
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Filtered Search Results
TARGETMOL CHEMICALS INC Pranoprofen 200MG
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Also available in 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Pranoprofen (Pyranoprofen) (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology. Purity 97.99%
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Apexbio Technology LLC ML 281 200mg
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ML 281 (CAS 1404437-62-2) is a small-molecule inhibitor targeting serine/threonine kinase STK33 It is designed to block the phosphorylation activity of STK33 thereby interfering with downstream signaling pathways regulated by STK33-mediated phosphorylation events ML 281 exerts its biological activity primarily through selective inhibition of STK33 kinase activity In biochemical assays ML 281 demonstrates potent inhibitory effects with an IC50 value of approximately 14 nM against STK33 Based on these pharmacological properties ML 281 holds research potential in investigating the biological role of STK33 in tumor cell survival cellular proliferation and oncogenic signal transduction pathways
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Chem-Impex International, Inc. Quinoline-6-carboxylic acid | MFCD00047613 | 1G
Quinoline-6-carboxylic acid, MFCD00047613, 1G
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![Medchemexpress LLC [3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carb | 1448316-08-2 | >98.0% | 558.53 | C26H19F5N6OS | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000213553.png-250.jpg)
Medchemexpress LLC [3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carb | 1448316-08-2 | >98.0% | 558.53 | C26H19F5N6OS | 50 MG
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BAY-826 is a small-molecule chemical probe that selectively inhibits the receptor tyrosine kinase TIE-2 (TEK). It shows low-nanomolar biochemical potency and potent cellular activity, and is supplied for research use in solid and DMSO solution formats for preclinical mechanism-of-action and signaling studies.
- Selective TIE-2 inhibition (Kd = 1.6 nM).
- Potent cellular activity (EC50 = 1.3 nM for TIE-2 autophosphorylation in HUVECs).
- Characterized kinase selectivity with limited off-target binding.
- Available as solid (5-500 mg) and as 10 mM solution in DMSO.
- Suitable for preclinical research applications and mechanistic studies.
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![Medchemexpress LLC [3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1h-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phen | 1448316-08-2 | 99.3% | 558.53 g/mol | C26H19F5N6OS | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000213130.png-250.jpg)
Medchemexpress LLC [3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1h-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phen | 1448316-08-2 | 99.3% | 558.53 g/mol | C26H19F5N6OS | 25 MG
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BAY-826 is a small-molecule chemical probe that selectively and potently inhibits the receptor tyrosine kinase TIE-2 (Kd ≈ 1.6 nM). It is supplied for research use only and has been characterized in preclinical studies. The compound has molecular formula C26H19F5N6OS and a molecular weight of 558.53 g/mol.
- Selective, potent TIE-2 inhibition with low nanomolar affinity.
- Characterized for in vitro and in vivo preclinical studies.
- Supplied as a solid and available in multiple pack sizes, with DMSO solutions for convenience.
- High chemical purity suitable for research applications.
- Molecular weight 558.53 g/mol and formula C26H19F5N6OS.
- Intended for research use only; not for clinical or human use.
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Accela Chembio Inc Quinoline-5-carboxylic Acid | 1g | 7250-53-5 | MFCD00047608 | 95+% | Shelf Life: 1440 Days | Regular
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Quinoline-5-carboxylic Acid | 1g | 7250-53-5 | MFCD00047608 | 95+% | Shelf Life: 1440 Days | Regular
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Apexbio Technology LLC Androgen receptor antagonist 9 915086-32-7 200mg
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Androgen receptor antagonist 9 (CAS 915086-32-7) is a small molecule inhibitor that binds to the androgen receptor (AR) thereby preventing androgens such as testosterone and dihydrotestosterone from interacting with the receptor By disrupting AR signaling pathways this compound can suppress the proliferation and growth of tumor cells in androgen-dependent malignancies Androgen receptor antagonist 9 is utilized in research investigating the pathogenesis and treatment of diseases such as prostate cancer where androgen signaling is implicated
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Apexbio Technology LLC MNS 1485-00-3 200mg
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MNS (CAS 1485-00-3) is a small molecule selectively inhibiting the tyrosine kinases Src and Syk It demonstrates antiaggregative activity by suppressing GPIIb/IIIa integrin activation with an IC50 of 12 7 M in thrombin-induced platelet aggregation assays MNS does not impact Ca2 -dependent enzymes protein kinase C or arachidonic acid pathways This selective kinase inhibition profile makes MNS a valuable tool for investigating platelet signaling mechanisms and the regulation of integrin-mediated cellular functions
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TARGETMOL CHEMICALS INC Rivastigmine 200MG
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Also available in 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease. Purity 99.85%
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TARGETMOL CHEMICALS INC Amorolfine hydrochloride 200MG
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Also available in 1 mL, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Amorolfine hydrochloride (Amorolfine HCl) is an antifungal reagent. It exerts the antifungal activity by selectively interrupting two steps in the pathway of ergosterol synthesis and eventually disrupting the function and structure of fungal cell membrane. Amorolfine hydrochloride , a morpholine antifungal drug, can inhibit D14 reductase and D7-D8 isomerase. These enzymes can deplete ergosterol and cause ignosterol to accumulate in the fungal cytoplasmic cell membranes. Purity 100%
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Apexbio Technology LLC Cinchonine(LA40221) 118-10-5 25mg
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Cinchonine LA40221 (118-10-5) is a small-molecule inhibitor designed to modulate biological processes such as inflammation tumorigenesis malaria infection obesity and platelet aggregation Cinchonine LA40221 exerts its biological activity primarily through regulation of signaling pathways modulation of enzyme activities and induction of apoptosis via caspase-3-dependent mechanisms In in vitro studies Cinchonine LA40221 demonstrates antitumor activity with IC50 values ranging approximately from 10-100 M depending on cell types and protocols Based on these pharmacological properties Cinchonine LA40221 holds research potential in studying malaria infection models cancer cell apoptosis inflammatory responses platelet function and obesity-related metabolic pathways
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Apexbio Technology LLC Vinpocetine 42971-09-5 200mg
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Vinpocetine (CAS 42971-09-5) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE) exhibiting a Ki of 14 2 M for Ca2 -dependent PDE in vitro It acts as a non-competitive inhibitor effectively modulating intracellular cGMP levels in smooth muscle In rat aortic cytosolic preparations vinpocetine inhibits Ca2 -PDE activity significantly while demonstrating minimal inhibition of Ca2 -independent cGMP PDE and cAMP PDE (Ki values 1000 M) Additionally vinpocetine attenuates 5-HT-induced contractions in intact rat aorta with an EC50 of 1 M This compound is used in research to explore mechanisms of smooth muscle relaxation and PDE regulation
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TARGETMOL CHEMICALS INC Triclabendazole 200MG
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Also available in 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Triclabendazole (CGA89317) has been used in trials studying Parasitic Disease. Purity 98.35%
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Selleck Chemical LLC Ciprofloxacin-50mg
Ciprofloxacin (Bay o 9867,Bay q 3939) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.
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Apexbio Technology LLC Cinchonidine 485-71-2 500mg
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Cinchonidine (CAS 485-71-2) is a small-molecule inhibitor targeting the serotonin transporter (SERT) It is designed to inhibit SERT function thereby modulating serotonin uptake activity Cinchonidine exerts its biological activity primarily through SERT inhibition In in vitro studies Cinchonidine demonstrates inhibitory activity with IC50 values of 330 M for dSERT and 4 2 36 196 and 15 M for hSERT and its mutants I172M S438T and Y95F respectively Based on these pharmacological properties Cinchonidine holds research potential in serotonin transporter regulation and malaria research
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