Quinolines and derivatives

Medchemexpress LLC Amino-PEG6-amine | 76927-70-3 | ≥ 97.0% | 324.41 | 100 MG

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Amino-PEG6-amine is a PEG-based (6 units) PROTAC linker. It can be used in the synthesis of PROTACs, which are molecules that exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. PROTACs achieve this by containing two different ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein.

• PEG-based PROTAC linker
• Used in the synthesis of PROTACs
• Exploits the ubiquitin-proteasome system
• Selectively degrades target proteins

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Medchemexpress LLC Trifluoperazine dihydrochloride | 440-17-5 | 99.98% | 10 MM 1 ML

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Trifluoperazine dihydrochloride is an antipsychotic agent that functions by blocking central dopamine receptors. It also acts as a potent alpha1-adrenergic receptor antagonist and a NUPR1 inhibitor, exhibiting anticancer activity. Furthermore, it is identified as a calmodulin inhibitor and an inhibitor of P-glycoprotein. This compound is suitable for research related to schizophrenia and has been observed to act as a reversible inhibitor of influenza virus morphogenesis.

• Antipsychotic agent
• Blocks central dopamine receptors
• Potent alpha1-adrenergic receptor antagonist
• Potent NUPR1 inhibitor
• Exhibits anticancer activity
• Calmodulin inhibitor
• Inhibitor of P-glycoprotein
• Suitable for research related to schizophrenia
• Reversible inhibitor of influenza virus morphogenesis

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Ambeed Tetraphenylphosphonium chlorid

Tetraphenylphosphonium chloride, 2001-45-8, 97%

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Ambeed 3 4Chlorophenyl N pyridin4ylme

3-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide, 915385-81-8, 98%

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Ambeed 1 1 Biphenyl 4ylboronic acid

[1,1'-Biphenyl]-4-ylboronic acid, 5122-94-1, 98%

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Ambeed 1Methylpyrrolidine

1-Methylpyrrolidine, 120-94-5, 95%

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Apexbio Technology LLC Q-VD-OPh 1135695-98-5 25mg

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Q-VD-OPh is a pan-caspase inhibitor targeting caspases including 1 3 8 and 9 with IC50 values ranging from approximately 25 to 400 nM By blocking multiple caspase-mediated apoptotic pathways including caspase-9/3 caspase-8/10 and caspase-12 pathways Q-VD-OPh prevents apoptotic cell death induced by agents such as actinomycin D In research contexts this inhibitor serves as a tool to investigate apoptosis mechanisms across diverse cell types and species including human mouse and rat It is also used to enhance cell viability upon thawing from cryopreservation under standard cryoprotectant conditions

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Apexbio Technology LLC Resiquimod (R-848) 144875-48-9 10mM (in 1mL DMSO)

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Resiquimod (R-848) is an immunomodulatory small molecule structurally related to imiquimod It functions primarily by activating immune responses via inducing cytokine release In vitro studies with human peripheral blood mononuclear cells (PBMC) indicate that Resiquimod promotes dose-dependent production of cytokines including interferon-alpha (IFN- ) tumor necrosis factor (TNF) interleukin-1 (IL-1 ) and interleukin-6 (IL-6) Mechanistically Resiquimod increases intracellular IL-1 levels and both monocytes and B-cells respond by secreting IFN upon stimulation In addition it elevates mRNA expression of IFN- TNF and IL-8 in treated PBMC relative to untreated controls Resiquimod demonstrates antiviral and antitumor activities in preclinical animal models frequently utilized as an immune response potentiator and Toll-like receptor (TLR) agonist in biomedical investigations (IC50 values typically range in low micromolar)

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Apexbio Technology LLC LY2886721 1262036-50-9 200mg

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LY2886721 (CAS 1262036-50-9) is an orally bioavailable inhibitor of -site amyloid precursor protein cleaving enzyme 1 (BACE1) an aspartyl protease integral to amyloid precursor protein (APP) cleavage and amyloid- (A ) generation LY2886721 inhibits BACE1 activity with an IC50 of approximately 20 3 nM effectively reducing soluble APP and elevating soluble APP in human cell models (HEK293Swe) and neuronal cultures (PDAPP) at IC50 values of 18 7 nM and 10 7 nM respectively In animal models such as PDAPP mice oral LY2886721 administration dose-dependently reduces cerebral A C99 and sAPP levels Due to its BACE1 inhibitory action LY2886721 serves as a valuable tool in Alzheimer s disease research and therapeutic development

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Apexbio Technology LLC APEXBIO TECHNOLOGY LLC

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