Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC Quinoline val-asp difluorophenoxymethylketone | 1135695-98-5 | MFCD08669741 | 99.9% | 513.49 g/mol | C26H25F2N3O6 | 100MG
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Q-VD-OPh is an irreversible, cell-permeable pan-caspase inhibitor used to block caspase-dependent apoptosis in biochemical and cell-based assays. It inhibits caspase-7 with an IC50 of 48 nM and shows activity against caspases 1, 3, 8, 9, 10, and 12 in the 25-400 nM range. Reported properties include low cytotoxicity and the ability to cross the blood-brain barrier.
- Potent pan-caspase inhibition with low nanomolar activity.
- Cell permeable for use in live-cell assays.
- Low intrinsic cytotoxicity in standard assays.
- Capable of crossing the blood-brain barrier.
- High chemical purity suitable for research applications.
- Supplied as a solid powder for convenient storage and handling.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000427211 SCOPOLETIN 200MG
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Chemscene ChemScene | 8-Bromo-5-nitroquinoline | 5G | CS-0035507 | 0.98 | 139366-35-1| MFCD00509069 | 253.055
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ChemScene | 8-Bromo-5-nitroquinoline | 5G | CS-0035507 | 0.98 | 139366-35-1| MFCD00509069 | 253.055
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000365867 OXALIPLATIN 200MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000365981 SULFO-ARA-F-NMN 50MG
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Apexbio Technology LLC Refametinib 923032-37-5 200mg
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Refametinib (CAS 923032-37-5) is an orally bioavailable selective allosteric inhibitor of mitogen-activated protein kinase kinases MEK1 and MEK2 It binds to an allosteric site distinct from the ATP-binding pocket thereby inhibiting MEK1 and MEK2 enzymatic activity (IC50 19 nM and 47 nM respectively) and blocking phosphorylation of ERK without interfering with ATP binding Refametinib demonstrates potent inhibition in human tumor cell lines with EC50 values ranging from 2 5 to 15 8 nM and suppresses proliferation in BRAF V600E-mutant lines (GI50 67 89 nM) It induces tumor growth delay and regression in xenograft models supporting its utility in cancer research
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![eMolecules Medchem Express / Difloxacin-d3 (hydrochloride) / 1mg / 769193262 / HY-121272AS1 / / 1173021-89-0 / [null] / 438.870 / C21H20ClF2N3O3](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502465315.JPG-250.jpg)
eMolecules Medchem Express / Difloxacin-d3 (hydrochloride) / 1mg / 769193262 / HY-121272AS1 / / 1173021-89-0 / [null] / 438.870 / C21H20ClF2N3O3
Medchem Express / Difloxacin-d3 (hydrochloride) / 1mg / 769193262 / HY-121272AS1 / / 1173021-89-0 / [null] / 438.870 / C21H20ClF2N3O3
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000427798 PAEONIFLORIN 200MG
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Apexbio Technology LLC Oltipraz 64224-21-1 200mg
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Oltipraz (CAS 64224-21-1) is a small-molecule activator targeting the nuclear factor erythroid 2 related factor 2 (Nrf2) signaling pathway It is designed to induce phase II detoxifying enzymes thereby modulating cellular defense mechanisms against xenobiotic and carcinogen exposure Oltipraz exerts its biological activity primarily through upregulation of phase II enzymes including glutathione S-transferase (GST) and NAD(P)H quinone oxidoreductase (NQO1) In rat hepatocyte assays Oltipraz demonstrates enzyme induction activity with an IC50 of approximately 10 30 M Based on these pharmacological properties Oltipraz holds research potential in chemoprevention and protection against carcinogen-related toxicity by modulation of Nrf2 signaling pathways
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000431727 CYANINE3 AMINE TFA 5MG
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5000449764 5-AMINO-8-HYDROXYQUI 10MM 1ML
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Apexbio Technology LLC Difloxacin HCl 91296-86-5 1g
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Difloxacin HCl (CAS 91296-86-5) is a small-molecule inhibitor targeting DNA gyrase and topoisomerase IV It is designed to interfere with DNA gyrase-mediated DNA synthesis thereby inhibiting bacterial DNA replication and cell division Difloxacin HCl exerts its biological activity primarily through inhibition of DNA gyrase and topoisomerase IV In cultured human neuroblastoma cells exhibiting multidrug resistance associated protein (MRP)-mediated chemoresistance difloxacin HCl (50 g/ml) increases cell sensitivity to MRP substrates including doxorubicin vincristine daunorubicin and potassium antimony tartrate indicating reversal of the drug-resistance phenotype Based on these pharmacological properties difloxacin HCl holds research potential in antimicrobial susceptibility testing and studies of multidrug resistance reversal
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eMolecules 2-HYDROXYQUINOLINE-7-CARBOXYLIC ACID | 320349-89-1 | MFCD11557271 | 1g
AstaTech | 2-HYDROXYQUINOLINE-7-CARBOXYLIC ACID | 1g | 381448227 | CS1524 | 95.000 | 320349-89-1 | MFCD11557271 | 189.170 | C10H7NO3
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TARGETMOL CHEMICALS INC Pentamidine 200MG
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Also available in 5 mg, 500 mg and bulk. Please contact Fisher for quotes. Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication. Purity 98.13%
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000453345 L-CYSTATHIONINE DIH 1MG
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