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Filtered Search Results
Chemscene CHEMSCENE
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5000579279 HYDROQUINIDINE 5G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000695532 HYDROQUININE 25G
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AdipoGen Quinine anhydrous
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Chemical. CAS 130-95-0. Formula C20H24N2O2. MW 324.42. Synthetic. Because of its relatively constant and well-known fluorescence quantum yield, quinine is also used in photochemistry as a common fluorescence standard. It has been used for imaging of oxygen evolution and oxide formation. Chloride and bromide have been shown to quench fluorescence. Generally it is famous as potassium channel blocker with antipyretic fever-reducing, antimalarial, analgesic painkilling, and anti-inflammatory properties.
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Medchemexpress LLC Imiquimod maleate | 896106-16-4 | 99.9% | 200 MG
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Imiquimod maleate is an immune response modifier and a selective toll-like receptor 7 (TLR7) agonist. It exhibits antiviral and antitumor effects in vivo. This product is used for research related to external genital, perianal warts, cancer, and COVID-19.
- Immune response modifier
- Selective toll-like receptor 7 (TLR7) agonist
- Exhibits antiviral and antitumor effects in vivo
- Used for research of external genital, perianal warts, cancer, and COVID-19
- Can be used to induce psoriasis models
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Apexbio Technology LLC Imiquimod hydrochloride 99011-78-6 100mg
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Imiquimod hydrochloride (CAS 99011-78-6) is a small-molecule agonist targeting Toll-like receptor 7 (TLR7) It is designed to activate TLR7 thereby triggering immune signaling cascades and promoting innate immune responses Imiquimod hydrochloride exerts its biological activity primarily through TLR7-mediated induction of pro-inflammatory cytokines such as IFN- TNF- and interleukin-12 In in vitro studies Imiquimod hydrochloride demonstrates TLR7 activation with an IC50 value of approximately 2 5 M varying according to experimental systems and conditions Based on these pharmacological properties Imiquimod hydrochloride holds research potential in studies of viral infections tumor immunotherapy and modulation of dermal immune responses
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Medchemexpress LLC Imiquimod (hydrochloride) | 99011-78-6 | 10 MM 1 ML
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Imiquimod hydrochloride, also known as R 837 hydrochloride, is an immune response modifier and a selective toll-like receptor 7 (TLR7) agonist. This compound exhibits antiviral and antitumor effects in vivo, making it valuable for various research applications.
- Used for research of external genital, perianal warts, cancer, and COVID-19
- Can induce psoriasis models
- Exhibits antiviral effects in vivo
- Exhibits antitumor effects in vivo
- Acts as a selective toll-like receptor 7 (TLR7) agonist
- Functions as an immune response modifier
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Apexbio Technology LLC APEXBIO TECHNOLOGY LLC
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5000568048 IMIQUIMOD-MALEATE-100MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000692238 IMIQUIMOD MALEATE 10MM/1ML
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000743885 RESIQUIMOD 50MG
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Apexbio Technology LLC Imiquimod 99011-02-6 100mg
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Imiquimod (CAS 99011-02-6) is a small-molecule agonist targeting Toll-like receptor 7 (TLR7) It is designed to activate TLR7 thereby modulating innate immune responses Imiquimod exerts its biological activity primarily through induction of cytokines such as interferon-gamma and interleukin-12 while suppressing IL-4 and IL-5 thus affecting cellular immunity In in vitro studies imiquimod demonstrates TLR7 activation with an EC50 of approximately 2 1 M and exhibits an anti-proliferative effect mediated by opioid growth factor (OGF) with an IC50 of 2 M Based on these pharmacological properties imiquimod holds research potential in cancer inflammatory diseases and dermatologic conditions including basal cell carcinoma superficial squamous cell carcinoma actinic keratosis and external genital warts
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Apexbio Technology LLC HA14-1 65673-63-4 200mg
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HA14-1 (CAS 65673-63-4) is a small molecule inhibitor of B-cell lymphoma 2 (Bcl-2) protein By binding to the BH3 domain of Bcl-2 HA14-1 antagonizes its anti-apoptotic function thereby promoting the activation of pro-apoptotic proteins such as Bax In NIH3T3 HL60 and H1299 cell lines HA14-1 induces apoptosis with reported IC50 values ranging from 10 to 20 M Additionally it has been shown to inhibit ceramide glucosyltransferase HA14-1 is widely utilized as a chemical tool to investigate Bcl-2-mediated apoptotic pathways and is of interest in cancer research exploring targeted induction of cell death
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Apexbio Technology LLC A-966492 934162-61-5 200mg
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A-966492 (CAS 934162-61-5) is a potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) exhibiting a Ki of 1 nM It also inhibits PARP-2 with a Ki of approximately 1 5 nM As a PARP inhibitor this compound interferes with the enzymatic activity essential for DNA repair pathways sensitizing cancer cells to cytotoxic therapies In vitro A-966492 shows effective inhibition in C41 cells with an EC50 of 1 nM and demonstrates moderate oral bioavailability (34-72%) and a half-life of around 1 7-1 9 hours It crosses the blood-brain barrier and has demonstrated activity in preclinical murine cancer models including B16F10 melanoma and BRCA1-deficient MX-1 breast cancer xenografts enhancing the efficacy of chemotherapeutic agents such as temozolomide and carboplatin
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Medchemexpress LLC Lenvatinib | 417716-92-8 | 99.8% | 1 G
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Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor. It inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, demonstrating potent antitumor activities. This compound shows antiproliferative activity and growth inhibition in various cell lines.
- Inhibits VEGFR2, VEGFR3, and VEGFR1
- Inhibits PDGFRα, PDGFRβ, and FGFR1
- Inhibits KIT and RET
- Demonstrates antiproliferative activity
- Available as a solid form
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Medchemexpress LLC Olmutinib | 1353550-13-6 | 99.5% / 99.9% | 486.59 | 200 MG
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Olmutinib is an orally active and irreversible third-generation EGFR tyrosine kinase inhibitor. It binds to a cysteine residue near the kinase domain and is used for Non-Small Cell Lung Cancer (NSCLC). This product is for research use only.
- Orally active
- Irreversible third-generation EGFR tyrosine kinase inhibitor
- Binds to a cysteine residue near the kinase domain
- Used for Non-Small Cell Lung Cancer (NSCLC)
- For research use only
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Apexbio Technology LLC Meclofenoxate hydrochloride 3685-84-5 200mg
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Meclofenoxate hydrochloride (CAS 3685-84-5) is a synthetic compound formed from dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA) It is understood to influence cholinergic neurotransmission likely by increasing acetylcholine levels in the central nervous system through metabolic conversion of DMAE Preclinical studies have demonstrated that meclofenoxate hydrochloride enhances memory retention and supports various aspects of cognitive function This molecule is widely utilized in neurological and cognitive research to explore mechanisms underlying neuroprotection memory enhancement and age-related cognitive decline
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