Quinolines and derivatives
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Filtered Search Results
TARGETMOL CHEMICALS INC PD158780 10MG
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Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. PD 158780 reversibly inhibits auto and transphosphorylation of all four members of the ErbB receptor superfamily EGFR ErbB2 ErbB3 and ErbB4 (IC50s 8uM 49 nM 52 nM and 52 nM in cell assay). purity: 99%
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Medchemexpress LLC Recombinant cynomolgus B7-H2/ICOSLG (His-tag) | 50 UG
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Recombinant extracellular domain of cynomolgus B7-H2/ICOSLG, expressed in HEK293 and supplied as a C-terminal His-tagged protein for research use in immunology and binding studies. Supplied as a lyophilized powder with QC data supporting interaction with human ICOS by SPR.
- Expressed in HEK293 mammalian cells, preserving native glycosylation
- C-terminal His tag for purification and detection
- Amino acid range M1-T256; accession XP_005548617.1
- Molecular weight approximately 50-70 kDa
- Lyophilized from PBS, pH 7.4, for convenient storage
- Endotoxin level <1 EU/μg as determined by LAL
- Reconstitute to ≥100 μg/mL in ddH2O; aliquot and freeze for long-term storage
- Validated binding to human ICOS by SPR (KD 5.42 nM)
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TARGETMOL CHEMICALS INC LY2940094 5MG
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Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. LY2940094 (LY-2940094) decreases ethanol self-administration in animal models. LY2940094 is an effective selective and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). purity: 99%
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eMolecules 219763-82-3 | 4-Hydroxyquinoline-6-carbonitrile | Apollo Scientific | MFCD08063203 | 170.171 | C10H6N2O | 96.000 | Oc1ccnc2ccc(cc12)C#N | 1g | 562462240
4-Hydroxyquinoline-6-carbonitrile | Apollo Scientific | 219763-82-3 | MFCD08063203 | 170.171 | C10H6N2O | 96.000 | Oc1ccnc2ccc(cc12)C#N | 1g | 562462240
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Medchemexpress LLC (S,R,S)-AHPC-CO-C9-acid | 2172819-78-0 | 95.0% | 628.82 | 50 MG
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(S,R,S)-AHPC-CO-C9-acid is an E3 ligase ligand-linker conjugate that can be connected to the ligand for protein to form PROTACs. This compound is intended for research use only.
- Functions as an E3 ligase ligand-linker conjugate.
- Can be connected to ligand for protein to form PROTACs.
- Exhibits antiproliferative activity against human NCI-H69 cells.
- Has an IC50 > 40 μM against NCI-H69 cells.
- Appearance: solid, white to off-white.
- Ships at room temperature in continental US.
- Storage conditions: 4°C, protect from light, stored under nitrogen.
- Soluble in various solvents including DMSO, PEG300, Tween-80, Saline, SBE-β-CD, and Corn Oil.
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Apexbio Technology LLC Zonisamide 68291-97-4 200mg
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Zonisamide (CAS 68291-97-4) is a small molecule antiepileptic agent characterized by its broad-spectrum anticonvulsant mechanisms It inhibits neuronal hyperexcitability primarily through blockade of voltage-gated sodium channels and T-type calcium channels Zonisamide also facilitates large-conductance calcium-activated potassium (BKCa) channel activity and modulates GABAergic glutamatergic and monoaminergic neurotransmission Due to its multifaceted pharmacological actions zonisamide is utilized in research focused on seizure disorders ion channel function and the modulation of central nervous system excitability
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eMolecules 69812-30-2 | 2-ACETAMIDOTHIAZOLE-5-SULFONYL CHLORIDE | AstaTech | MFCD05022486 | 240.680 | C5H5ClN2O3S2 | 95.000 | CC(=O)Nc1ncc(s1)S(Cl)(=O)=O | 1g | 233631706
2-ACETAMIDOTHIAZOLE-5-SULFONYL CHLORIDE | AstaTech | 69812-30-2 | MFCD05022486 | 240.680 | C5H5ClN2O3S2 | 95.000 | CC(=O)Nc1ncc(s1)S(Cl)(=O)=O | 1g | 233631706
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Medchemexpress LLC Guanidinoethyl sulfonate | 543-18-0 | 99.9% | 167.19 | 50 MG
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Guanidinoethyl sulfonate | 543-18-0 | 99.9% | 167.19 | 50 MG
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Medchemexpress LLC VK-II-86 | 955371-84-3 | 93.3% | 420.50 | 500 MG
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VK-II-86 is a Carvedilol analogue that lacks antagonist activity at β-adrenoceptors in hypokalaemia. This compound effectively prevents hypokalaemia-induced ventricular arrhythmia through its multi-channel effects, counteracting all hypokalaemia-induced changes in ion channel activity and oxidative stress. For research use only.
- Carvedilol analogue
- Lacks antagonist activity at β-adrenoceptors
- Prevents hypokalaemia-induced ventricular arrhythmia
- Exhibits multi-channel effects
- Counters hypokalaemia-induced changes in ion channel activity
- Counters hypokalaemia-induced oxidative stress
- Markedly reduces non-sustained and sustained ventricular tachyarrhythmias in a hypokalaemic murine whole-heart model
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![Medchemexpress LLC 2-phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide | 113906-27-7 | 99.9% | 320.34 g·mol⁻¹ | C19H16N2O3 | 200 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000213508.png-250.jpg)
Medchemexpress LLC 2-phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide | 113906-27-7 | 99.9% | 320.34 g·mol⁻¹ | C19H16N2O3 | 200 MG
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PNU-74654 is a small-molecule inhibitor of the Wnt/β-catenin signaling pathway that disrupts the β-catenin-TCF interaction. It is supplied for research use and is characterized by reported cellular activity (IC50 129.8 μM in NCI-H295 cells), defined physicochemical properties, and high purity suitable for biochemical and cell-based assays.
- Inhibits Wnt/β-catenin signaling by blocking β-catenin-TCF interaction.
- Reported cellular potency: IC50 129.8 μM in NCI-H295 cells.
- High chemical purity for reliable experimental results.
- Well characterized physicochemical properties (MW 320.34, formula C19H16N2O3).
- Suitable for in vitro biochemical and cell-based assays (research use only).
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Medchemexpress LLC Cyclopamine | 4449-51-8 | 411.62 | 200 MG
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Cyclopamine is a steroidal alkaloid and a selective Smo inhibitor that acts as a Hedgehog (Hh) pathway antagonist, with an IC50 of 46 nM in Hh cell assays. It is used in research for its ability to suppress cell growth and inhibit Hh signaling.
- Hedgehog (Hh) pathway antagonist
- Selective Smo inhibitor
- Suppresses cell growth
- Inhibits Hh signaling through direct interaction with Smo
- Suitable for research and analytical applications
- Induces tumor remission in medulloblastoma models
- Blocks tumor formation in pancreatic adenocarcinoma cells
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Medchemexpress LLC 9-(oxolan-2-yl)purin-6-amine | 17318-31-9 | MFCD00210216 | ≥98.0% | 205.22 g/mol | C9H11N5O | 200 MG
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SQ22536 is a small-molecule adenylate cyclase inhibitor used in research to modulate cAMP signaling. It is provided as a powder and is characterized by CAS 17318-31-9, molecular formula C9H11N5O, and molecular weight 205.22 g/mol. The compound is suitable for laboratory-scale in vitro and in vivo studies with documented solubility and storage recommendations.
- Potent adenylate cyclase inhibitor for cAMP pathway studies.
- Suitable for in vitro and in vivo applications with established vehicle formulations.
- Soluble in DMSO and water at experimentally useful concentrations.
- Stable as a powder under cold storage with multi-year shelf life.
- Provided as an analytical standard for research use only.
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Apexbio Technology LLC WAY-100635 162760-96-5 200mg
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WAY-100635 (CAS 162760-96-5) is a highly selective antagonist of the serotonin 5-HT1A receptor In vitro studies show that WAY-100635 displaces the 5-HT1A radioligand [3H]8-OH-DPAT from rat hippocampal membranes with a pIC50 of 8 87 and acts as a potent antagonist in functional assays without agonist or partial agonist activity In ex vivo guinea pig ileum assays it effectively blocks 5-carboxamidotryptamine-induced 5-HT1A responses (pA2 9 71 at 0 3 nM) In vivo WAY-100635 counteracts 8-OH-DPAT-induced behavioral and thermoregulatory effects in rodents at subcutaneous doses as low as 0 003 0 01 mg/kg It is widely utilized in neuropharmacological research and neuroimaging as a SPECT/PET ligand to investigate 5-HT1A receptor function in psychiatric and neurological disorders
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Medchemexpress LLC 3-(N-maleimido-propionylamino)-propyl-sulfonic acid sodium salt | 185332-92-7 | MFCD17215919 | 98.8% | 382.28 g·mol⁻¹ | C12H11N2NaO9S | 25 MG
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Sulfo-GMBS is a water-soluble, heterobifunctional cross-linker bearing a sulfo-NHS ester reactive toward primary amines and a maleimide reactive toward sulfhydryl groups. It enables efficient amine-to-thiol conjugation in aqueous buffers for protein and peptide modification, labeling, and cross-linking workflows. The sodium sulfonate improves aqueous solubility for biological applications.
- Water-soluble heterobifunctional cross-linker for amine-to-thiol coupling
- Contains a sulfo-NHS ester reactive toward primary amines
- Contains a maleimide group selective for sulfhydryl groups
- Suitable for conjugation in aqueous buffers and physiological conditions
- High purity supports consistent conjugation performance
- Applicable to protein labeling, cross-linking, and bioconjugation assays
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Apexbio Technology LLC Amadacycline 389139-89-3 200mg
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Amadacycline (CAS 389139-89-3) is a tetracycline-class antibiotic targeting the bacterial ribosomal 30S subunit It is designed to inhibit bacterial protein synthesis thereby preventing microbial proliferation Amadacycline exerts its biological activity primarily through interference with bacterial translation by inhibiting the 30S ribosomal subunit The exact IC50 value for Amadacycline has not been established Based on these pharmacological properties Amadacycline holds research potential in investigating antibiotic resistance mechanisms bacterial ribosome-targeting strategies and as a candidate in studies evaluating therapeutic agents for complicated skin and skin structure infections
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