Quinolines and derivatives
TARGETMOL CHEMICALS INC Tandutinib 200MG
Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50 0.22 uM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR, and KDR. Purity 99.74%
Medchemexpress LLC Vactosertib | 1352608-82-2 | 99.5% | 399.42 | 200 MG
Vactosertib (EW-7197) is a potent, orally active, and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor. It inhibits ALK2 and ALK4 at nanomolar concentrations and exhibits potent antimetastatic activity and anticancer effects. With a high purity of 99.53% and molecular weight of 399.42, this solid, off-white to yellow compound is a valuable tool for cancer research.
- Potent and orally active ALK5 inhibitor
- Inhibits ALK2 and ALK4
- Shows antimetastatic and anticancer effects
- Blocks TGFβ-induced phosphorylation of Smad2 or Smad3
- Suppresses TGFβ-induced nuclear translocation of Smad2/3
- Abrogates TGFβ1-induced tumor cell migration and invasion
- Abolishes TGFβ1-induced effects on genes related to epithelial-to-mesenchymal transition
Medchemexpress LLC Sitravatinib | 1123837-84-2 | 99.6% | 629.68 | 200 MG
Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor that demonstrates potent single-agent antitumor efficacy. It enhances the activity of PD-1 blockade by promoting an antitumor immune microenvironment, making it suitable for various research applications in oncology.
- Orally bioavailable receptor tyrosine kinase (RTK) inhibitor
- Potent single-agent antitumor efficacy
- Enhances PD-1 blockade activity
- Promotes an antitumor immune microenvironment
- Soluble in DMSO for in vitro studies
- Available in solid form for various research needs
Apexbio Technology LLC Tandutinib (MLN518) 387867-13-2 200mg
Tandutinib (MLN518 CAS 387867-13-2) is a selective small molecule inhibitor primarily targeting FLT3 with additional activity against PDGFR and c-Kit In biochemical kinase assays Tandutinib exhibits IC50 values of 0 22 M for FLT3 0 20 M for PDGFR and 0 17 M for c-Kit It effectively inhibits tyrosine phosphorylation of both wild-type FLT3 and FLT3 mutants with IC50 values in the 30 100 nM range In cellular models Tandutinib demonstrates anti-proliferative effects in FLT3-ITD-positive cell lines (Molm-13 Molm-14) at low nanomolar concentrations whereas FLT3-ITD-negative cells are substantially less sensitive This compound is utilized in research investigating FLT3-mediated signaling and acute myelogenous leukemia (AML) pathogenesis
Medchemexpress LLC Rivastigmine (tartrate) | 129101-54-8 | MFCD03700731 | 99.03% | 400.42 | 50 MG
Rivastigmine tartrate is an orally active and potent cholinesterase (ChE) inhibitor. It inhibits butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). This compound can pass the blood-brain barrier (BBB) and is used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
- Orally active and potent cholinesterase (ChE) inhibitor
- Inhibits butyrylcholinesterase (BChE) and acetylcholinesterase (AChE)
- Can pass the blood-brain barrier (BBB)
- Used for research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease
- Reduces LPS-induced TNF-α and IL-6 in vitro
- Improved behavioral impairments caused by Aluminum in male Wistar albino rats
- Reduced IL-6 concentration in BALB/c OlaHsd male mice with acute colitis
Medchemexpress LLC SPP-86 | 1357349-91-7 | 99.9% | 277.32 | 100 MG
SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. It inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling, and also inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells. This compound is a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM.
- Inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling.
- Inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells.
- Click chemistry reagent, containing an alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
Medchemexpress LLC Sulfo-cyanine3 azide (potassium) | 95.3% | 736.94 | 1 MG
Sulfo-cyanine3 azide potassium is an azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). It can be used for synthesis of fused tricyclic heterocycles, producing immunostimulatory agents. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups, or ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
- Azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm).
- Used for synthesis of fused tricyclic heterocycles, producing immunostimulatory agents.
- Contains an azide group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups.
- Undergoes ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
![Medchemexpress LLC Ethanesulfonic acid, 2-[(aminoiminomethyl)amino]- | 543-18-0 | 99.9% | 167.19 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000436072-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC Ethanesulfonic acid, 2-[(aminoiminomethyl)amino]- | 543-18-0 | 99.9% | 167.19 | 100 MG
Guanidinoethyl sulfonate (Standard) is an analytical standard and an orally available, blood-brain permeable competitive inhibitor of taurine transporters. It acts as a competitive antagonist of glycine receptors (GlyR) (IC50=565 μM) and shows weak agonist/antagonist effects on GABAA receptors. It inhibits taurine transmembrane transport, blocks glycine-mediated chloride influx, and may regulate brain pH for neuroprotective effects, useful in studies of ischemic brain injury. It is applied in qualitative, quantitative, and methodological research experiments including HPLC, GC, and MS.
- Analytical standard for research
- Orally available and blood-brain permeable
- Inhibits taurine transporters
- Antagonizes glycine receptors
- Modulates GABAA receptors
- Blocks glycine-mediated chloride influx
- May offer neuroprotective effects
- Used in HPLC, GC, and MS applications
Medchemexpress LLC Verteporfin | 129497-78-5 | 98.2% | 200 MG
Verteporfin (CL 318952) is a photosensitizer used in photodynamic therapy to eliminate abnormal blood vessels in the eye, especially those associated with age-related macular degeneration. It functions as a YAP inhibitor by disrupting YAP-TEAD interactions, inducing cell apoptosis. This compound also acts as an autophagy inhibitor, blocking autophagosome formation at an early stage.
- Acts as a YAP inhibitor, disrupting YAP-TEAD interactions.
- Induces cell apoptosis.
- Inhibits autophagy by blocking autophagosome formation at an early stage.
- Utilized as a photosensitizer for photodynamic therapy.
- Shows light-independent anti-leukemic activity.
- Reduces mitochondrial membrane potential in PDX cells.
- Reverses certain drug resistances by inhibiting YAP expression.
Medchemexpress LLC Apalutamide | 956104-40-8 | 99.9% | 477.43 | 200 MG
Apalutamide is a potent and competitive antagonist of the androgen receptor (AR), binding to it with an IC50 of 16 nM. It is intended for research use.
- Exhibits low micromolar affinity (IC50 3 μM) for the GABAA receptor, potentially antagonizing GABAA at therapeutic dose levels.
- Targets the AR ligand-binding domain, preventing AR nuclear translocation, DNA binding, and transcription of AR gene targets.
- Shows low systemic clearance, high oral bioavailability, and a long plasma half-life in both mouse and dog, supporting once-daily oral dosing.
- Achieves increased steady-state plasma levels in repeat-dose studies, resulting in high C24hr levels and low peak:trough ratios (2.5).
- Demonstrated significant tumor-volume reduction in castrate male mice bearing LNCaP/AR xenograft tumors.
Medchemexpress LLC 1-Piperazineacetamide, N-(2,6-dimethylphenyl)- | 5294-61-1 | 99.8% | 247.34 | 200 MG
CVT-2738 is an orally active metabolite of Ranolazine. It demonstrates a protective effect against Isoprenaline-induced myocardial ischemia in mice and is suitable for use in myocardial ischemia research.
- Orally active metabolite
- Demonstrates protective effect against myocardial ischemia
- Suitable for myocardial ischemia research
- Ships at room temperature
- Stable as powder for 3 years at -20°C
- Soluble in DMSO (10 mg/mL)
Medchemexpress LLC Valbenazine | 1025504-45-3 | 98.6% | 418.57 | 200 MG
Valbenazine is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki of 110-190 nM. It exhibits VMAT2 binding affinity in rat striatum and human platelets. In vivo, Valbenazine induces ptosis and increases plasma prolactin in rats.
- VMAT2 inhibitor.
- Exhibits VMAT2 binding affinity in rat striatum and human platelets.
- Induces ptosis and increases plasma prolactin in rats.
- Available in solid and solution forms.
- Can be stored long-term as powder at -20°C (3 years) or 4°C (2 years).
- In solvent, stock solutions can be stored at -80°C (2 years) or -20°C (1 year).
Medchemexpress LLC Kaempferol | 520-18-3 | MFCD00004543 | 99.9% | C15H10O6 | 200 MG
Kaempferol is a naturally occurring flavonoid found in various edible plants. This compound functions as an estrogen receptor alpha inhibitor in breast cancer cells and promotes apoptosis in glioblastoma and lung cancer cells through MEK-MAPK activation. It is recognized as a human endogenous metabolite.
- Inhibits estrogen receptor alpha expression in breast cancer cells.
- Induces apoptosis in glioblastoma and lung cancer cells.
- Demonstrates anti-inflammatory activity.
- Exhibits antioxidant activity in human HepG2 cells.
- Shows antiproliferative activity against certain human cancer cell lines.
- Displays antiallergic activity.
- Demonstrates antiviral activity against influenza A virus.
- Inhibits melanogenesis.
- Inhibits procoagulant activity.
- Induces osteoclast apoptosis.
- Exhibits antiaggregatory activity in human platelets.
Medchemexpress LLC Cisapride | 81098-60-4 | 99.9% | C23H29ClFNO4 | 200 MG
Cisapride is an orally active 5-HT4 receptor agonist with an EC50 value of 140 nM. It is also a hERG blocker with an IC50 value of 9.4 nM. This gastroprokinetic agent stimulates gastrointestinal motor activity and is intended for research use only.
- Orally active 5-HT4 receptor agonist
- hERG blocker
- Stimulates gastrointestinal motor activity
- Suitable for high-speed applications
- Available in various solid pack sizes
Medchemexpress LLC Vebicorvir | 2090064-66-5 | 99.7% | 467.44 | 10 MM 1 ML
Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor. It suppresses covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s ranging from 1.84 μM to 7.3 μM. In vitro, it inhibits pgRNA, HBeAg, and HBsAg production, and is also an inhibitor of pgRNA encapsidation and rcDNA synthesis. The product appears as a white to off-white solid for research use only.
- Suppresses covalently closed circular DNA (cccDNA) formation
- Inhibits pgRNA, HBeAg, and HBsAg production
- Inhibits pgRNA encapsidation and rcDNA synthesis
- Appears as a white to off-white solid