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Filtered Search Results
Medchemexpress LLC ACT-1004-1239 | 2178049-58-4 | 98.8% | C27H28F2N6O3 | 1 ML
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ACT-1004-1239 is a potent, selective, orally active CXCR7 antagonist with an IC50 value of 3.2 nM. It is intended for research use only and not sold to patients.
- Inhibits human, dog, rat, mouse, guinea pig, and macaque CXCR7 with IC50s ranging from 0.6 to 3.2 nM.
- Promotes oligodendrocyte precursor cell (OPC) differentiation by increasing CXCL12 levels.
- Increases plasma CXCL12 concentration in vivo.
- Reduces disease severity in an EAE model.
- Increases myelination in a Cuprizone-induced demyelination model.
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Boston Bioproducts Inc Ethidium Bromide (10 mg/ml) - 10ml
Ethidium Bromide (10 mg/ml) - 10ml (For Research Use and Further Manufacturing Only)
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![Medchemexpress LLC 3-piperidinecarboxamide, 1-(cyclopropylmethyl)-4-[[[5-(2,4-difluorophenyl)-3-isoxazolyl]carbonyl]am | 2178049-58-4 | 98.8% | 522.55 | C27H28F2N6O3 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000221277.png-250.jpg)
Medchemexpress LLC 3-piperidinecarboxamide, 1-(cyclopropylmethyl)-4-[[[5-(2,4-difluorophenyl)-3-isoxazolyl]carbonyl]am | 2178049-58-4 | 98.8% | 522.55 | C27H28F2N6O3 | 5 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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ACT-1004-1239 is a potent, selective, orally active CXCR7 (ACKR3) antagonist supplied for research use. It shows nanomolar potency in biochemical assays and has demonstrated target engagement and pharmacological effects in preclinical models, including modulation of CXCL12/CXCL11 signaling and efficacy in rodent disease models. Supplied formats support both in vitro and in vivo study designs.
- Potent CXCR7 antagonism with reported IC50 of 3.2 nM.
- High purity suitable for research applications.
- Available as solid and 10 mM DMSO solution for convenient use.
- Appropriate for in vitro and in vivo pharmacology studies.
- For research use only; not for human or veterinary use.
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Cayman Chemical Propidium Iodide 100MG
A fluorescent probe commonly used to identify dead cells; excitation at 488-535 nm and emission maximum of 617 nm
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Medchemexpress LLC Propidium Iodide | 25535-16-4 | 99.69% | 100 MG
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Propidium Iodide (PI) is a nuclear staining agent that stains DNA. It is an analogue of ethidine bromide that emits red fluorescence when embedded in double-stranded DNA. PI cannot pass through living cell membranes, but it can pass through damaged cell membranes to stain the nucleus. It has a fluorescence wavelength of 493/617 nm and 536/635 nm after Mosaic with DNA. Propidium Iodide is commonly used in the detection of apoptosis or necrosis, and is often used in flow cytometry analysis.
- Nuclear staining agent for DNA.
- Emits red fluorescence upon embedding in double-stranded DNA.
- Passes through damaged cell membranes to stain the nucleus.
- Fluorescence wavelength: 493/617 nm and 536/635 nm (after Mosaic with DNA).
- Commonly used in the detection of apoptosis or necrosis.
- Often used in flow cytometry analysis.
- Used in cell cycle and cell viability assays.
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Medchemexpress LLC Dihydroethidium | 104821-25-2 | 98.83% | 5 MG
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Dihydroethidium | 104821-25-2 | 98.83% | 5 MG
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Medchemexpress LLC EthD bromide | 1239-45-8 | 99.27% | 250 MG
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EthD bromide is an intercalating agent commonly used as a fluorescent tag (nucleic acid stain) in molecular biology laboratories for techniques such as agarose gel electrophoresis. It binds to DNA for visualization under UV light.
- Fluorescent tag for nucleic acids
- Intercalating agent
- Used for agarose gel electrophoresis
- Used in studies to reduce mitochondrial DNA copy number
- Used in Western blot analysis of proteins in the cGAS-STING pathway
- Visualizes EtBr uptake via hemichannels in astrocytes
- Targets DNA for staining
- Involves the cell cycle/DNA damage pathway
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AdipoGen Ethidium bromide Solution
Chemical. CAS 1239-45-8. Formula C21H20BrN3. MW 394.31. Synthetic. Ethidium bromide EtBr is the most commonly used nucleic acid stain for PAGE or agarose gel electrophoresis. The fluorescence of EtBr increases 21-fold upon binding to double-stranded RNA and 25-fold on binding double-stranded DNA so that destaining the background is not necessary with a low stain concentration 10 µg/ml. Ethidium bromide has been used in a number of fluorimetric assays for nucleic acids. Ethidium bromide intercalates double-stranded DNA and RNA and acts as a frameshift mutagen. It confers a deep red stain to DNA by acting as an intercalating agent between the starch bases. It has been shown to bind to single-stranded DNA although not as strongly and triple-stranded DNA. Because of its ability to bind to DNA, EtBr is an inhibitor of DNA polymerase. It can be used in conjunction with acridine orange to differentiate between viable, apoptotic and necrotic cells.
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Medchemexpress LLC DIHYDREXIDINE HYDRO 25 mg
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DIHYDREXIDINE HYDRO 25MG
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Cayman Chemical PropIdIum IodIde 50mg
A fluorescent probe commonly used to identify dead cells; excitation at 488-535 nm and emission maximum of 617 nm
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Ambeed AMBEED
5000884225 65H-PHENANTHRIDINONE 25G
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Selleck Chemical LLC Ethidium bromide S3689-25mg
Ethidium Bromide (Homidium bromide EtBr EB) is an intercalating agent which resembles a DNA base pair and commonly used as a fluorescent tag (nucleic acid stain) in molecular biology laboratories for techniques such as agarose gel electrophoresis
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Selleck Chemical LLC Dihydroethidium
Dihydroethidium (DHE HE Hydroethidine PD-MY 003) is a cell-permeable blue fluorogenic probe used for detecting intracellular superoxide radical anion
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AdipoGen Dihydroethidium
Chemical. CAS 104821-25-2. Formula C21H21N3. MW 315.41. Synthetic. Redox indicator. Blue fluorescence until oxidized to ethidium. Can be used for detecting superoxide radical in cells, tissues and organisms.
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AdipoGen Propidium iodide
Chemical. CAS 25535-16-4. Formula C27H34I2N4. MW 668.39. Synthetic. Propidium iodide is the most common red-fluorescent nuclear stain. It can also be excited using excitation filters appropriate for green-fluorescent dyes.
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