Quinolines and derivatives
eMolecules 4-Hydroxyquinoline-6-carbonitrile | 219763-82-3 | MFCD08063203 | 1g
Apollo Scientific | 4-Hydroxyquinoline-6-carbonitrile | 1g | 562462240 | OR350490 | 96.000 | 219763-82-3 | MFCD08063203 | 170.171 | C10H6N2O
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eMolecules 3-Quinolinecarboxylic acid, 6-bromo-4-chloro-8-methyl-, ethyl ester | 1016780-82-7 | MFCD09933645 | 1g
WuXi ChemSupply | 3-Quinolinecarboxylic acid, 6-bromo-4-chloro-8-methyl-, ethyl ester | 1g | 599171267 | LN04533159 | 95.000 | 1016780-82-7 | MFCD09933645 | 328.590 | C13H11BrClNO2
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Apexbio Technology LLC PF-543 1415562-82-1 200mg
PF-543 (CAS 1415562-82-1) is a cell-permeable inhibitor targeting sphingosine kinase 1 (SphK1) an enzyme that phosphorylates sphingosine to sphingosine-1-phosphate (S1P) It displays potent inhibitory activity against SphK1 with an IC50 of 3 6 nM through sphingosine-competitive (non-ATP competitive) binding Treatment of SphK1-overexpressing head and neck cancer (1483) cells led to a ten-fold decrease in S1P levels confirming effective target engagement PF-543 is widely utilized as a research tool in studies investigating SphK1-mediated signaling pathways in cancer biology and immune cell trafficking