Thienodiazepines
![Medchemexpress LLC 10H-Thieno[2,3-b]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)- | 132539-06-1 | 99.4% | C17H20N4S | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC 10H-Thieno[2,3-b]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)- | 132539-06-1 | 99.4% | C17H20N4S | 50 MG
Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist. It demonstrates high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6, dopamine D1-4, muscarinic M1-5, and adrenergic α1 receptors. Olanzapine is recognized as an atypical antipsychotic.
- Selective, orally active monoaminergic antagonist
- High affinity binding to serotonin, dopamine, muscarinic, and adrenergic α1 receptors
- Induces autophagy in human SH-SY5Y neuronal cells
- Exhibits anti-proliferative effects in glioblastoma cell lines
- Enhances Temozolomide's anti-tumor activity
- Induces apoptosis and necrosis in glioblastoma cell lines
Medchemexpress LLC Olanzapine | 132539-06-1 | 99.4% | C17H20N4S | 100 MG
Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist. It exhibits high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6, dopamine D1-4, muscarinic M1-5, and adrenergic α1 receptors. It is classified as an atypical antipsychotic.
- Targets multiple receptors including 5-HT, dopamine, mAChR, and adrenergic receptors
- Inhibits proliferation in glioblastoma cell lines
- Enhances temozolomide's anti-tumor activity
- Induces apoptosis and necrosis in glioblastoma cell lines
- Suitable for research in neurological disease and cancer
Apexbio Technology LLC OLANZAPINE-D3-1MG
Olanzapine-d3 (CAS No 786686-79-1) is used in biomedical research primarily for studying psychotropic drug mechanisms Originating as a deuterated analog of olanzapine its mechanism of action involves antagonism of serotonin 5-HT2A/2C and dopamine D2 receptors This compound demonstrates in vitro activity typically in the nanomolar to low micromolar range indicative of significant receptor affinity Common applications include studies in cell models to evaluate receptor binding as well as in animal models to assess behavioral and physiological outcomes particularly related to antipsychotic effects Additionally Olanzapine-d3 is valuable in drug screening processes enabling researchers to investigate metabolic stability and drug-drug interactions Experimental concentrations typically depend on the specific research design ensuring that findings are relevant to the intended study parameters