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Human GIP(3-30), amide is a high-affinity antagonist of the human GIP receptor in vitro. It is being investigated for its potential anti-obesity and anti-diabetic effects.
High affinity antagonist: Competitively binds to the GIP receptor (GIPR), blocking GIP-mediated cAMP accumulation (Ki=16.8 nM), β-arrestin recruitment (Ki for β-arrestin-1/2 recruitment is 10.6 nM and 10.2 nM), and receptor internalization.
Inhibits insulin secretion: It has been shown to inhibit GIP-mediated insulin secretion and signal transduction in adipocytes.
Selective for human GIP receptor: This compound demonstrates high-affinity binding to primate GIP receptors but not rodent GIP receptors.
Research use only: This product is intended solely for research purposes and is not for sale to patients.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Human GIP(3-30), amide TFA is the TFA salt form of human GIP(3-30), amide (HY-P10138). It is a high affinity antagonist of the human GIP receptor in vitro. Human GIP(3-30), amide TFA has potential anti-obesity and anti-diabetic effects.
High affinity antagonist of the human GIP receptor in vitro.
Potential anti-obesity effects.
Potential anti-diabetic effects.
Competitively binds to GIP receptor (GIPR), blocking GIP-mediated cAMP accumulation (Ki=16.8 nM), β-arrestin recruitment (Ki for β-arrestin-1/2 recruitment is 10.6 nM and 10.2 nM) and receptor internalization.
Inhibits GIP mediated insulin secretion and signal transduction in adipocytes.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Pyridin-4-ol is a biochemical reagent suitable for various life science related research applications. It serves as a biological material or an organic compound.
High purity of 99.86%
Supplied as a white to yellow solid
Ideal for diverse life science research
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More