Thienopyridines
Medchemexpress LLC AMI-1 free acid | 134-47-4 | 99.5% | 504.49 | 1 ML
AMI-1 free acid is a potent, cell-permeable, and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM for human PRMT1 and 3.0 μM for yeast-Hmt1p. It exerts its inhibitory effects on PRMTs by blocking peptide-substrate binding.
- Potent, cell-permeable, and reversible inhibitor of PRMTs.
- Inhibits type I PRMTs and type II PRMT5.
- Specifically inhibits arginine methyltransferase activity, not lysine, and does not compete for the AdoMet binding site.
- Inhibits methylation of GFP-Npl3 and cellular proteins.
- Inhibits the cell viability of sarcoma in S180 and U2OS cells in a time- and dose-dependent manner in vitro.
- Reduces S180 cell viability through the induction of cell apoptosis.
- Inhibits S180 viability in vivo.
- Downregulates PRMT5 and decreases levels of H4R3me2s and H3R8me2s in a tumor xenograft model.
![eMolecules Pharmablock / thieno[32-b]pyridine-7-carboxylic acid / 25mg / 551187853 / PB00454 / 0.000 / 1416714-01-6 / MFCD22689884 / 179.190 / C8H5NO2S](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502456401.PNG-250.jpg)
eMolecules Pharmablock / thieno[32-b]pyridine-7-carboxylic acid / 25mg / 551187853 / PB00454 / 0.000 / 1416714-01-6 / MFCD22689884 / 179.190 / C8H5NO2S
Pharmablock / thieno[32-b]pyridine-7-carboxylic acid / 25mg / 551187853 / PB00454 / 0.000 / 1416714-01-6 / MFCD22689884 / 179.190 / C8H5NO2S
Medchemexpress LLC N-Carbobenzyloxy-amino-L-alanine | 35761-26-3 | 238.24 | 25 G
N-Carbobenzyloxy-amino-L-alanine is an alanine derivative. Amino acids and their derivatives are used commercially as ergogenic supplements, influencing various physiological activities. This compound offers beneficial properties as an ergogenic dietary substance.
- Alanine derivative
- Used as an ergogenic supplement
- Influences secretion of anabolic hormones
- Enhances fuel supply during exercise
- Improves mental performance under stress
- Prevents exercise-induced muscle damage
Medchemexpress LLC AMI-1 | 20324-87-2 | 98.0% | 548.45 | 25 MG
AMI-1 is a potent, cell-permeable, and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM for human PRMT1 and 3.0 μM for yeast-Hmt1p. It inhibits PRMTs by blocking peptide-substrate binding.
- Potent, cell-permeable, and reversible inhibitor
- Inhibits in vitro methylation reactions performed by PRMT1, -3, -4, -6, and Hmt1p
- Inhibits both type I and type II PRMTs
- Specifically inhibits arginine methyltransferase activity
- Does not compete for the AdoMet binding site
- Inhibits methylation of GFP-Npl3 and cellular proteins
Medchemexpress LLC Tafluprost ethyl amide | 1185851-52-8 | 95.0% | 437.52 g·mol⁻¹ | C24H33F2NO4 | 5 MG
Tafluprost ethyl amide is an analytical reference standard of a prostaglandin derivative used in ophthalmic research to study intraocular pressure and eyelash growth. It is supplied for analytical and research applications; users should consult the Certificate of Analysis and SDS for exact purity and storage conditions.
- Analytical reference standard for assay development and quality control.
- Prostaglandin derivative relevant to ocular pharmacology research.
- Suitable for studies of intraocular pressure reduction and eyelash effects.
- Supplied in small milligram quantities appropriate for analytical use.
- Certificate of Analysis and SDS available for purity and storage details.
![eMolecules ChemScene / Furo[32-b]pyridine-6-carboxylic acid / 100mg / 632295551 / CS-0155526 / 0.000 / 122535-04-0 / MFCD13193320 / 163.132 / C8H5NO3](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502451279.PNG-250.jpg)
eMolecules ChemScene / Furo[32-b]pyridine-6-carboxylic acid / 100mg / 632295551 / CS-0155526 / 0.000 / 122535-04-0 / MFCD13193320 / 163.132 / C8H5NO3
ChemScene / Furo[32-b]pyridine-6-carboxylic acid / 100mg / 632295551 / CS-0155526 / 0.000 / 122535-04-0 / MFCD13193320 / 163.132 / C8H5NO3
Apexbio Technology LLC Thieno-CTP 5x100ul (100 mM)
Thieno-CTP is a structural analog of cytidine triphosphate (CTP) that incorporates a thiophene-modified nucleobase allowing incorporation into RNA by RNA polymerases during transcription Following enzymatic incorporation into nascent RNA transcripts the introduced thienyl modification acts as a reactive site suitable for subsequent bioorthogonal labeling via selective chemical reactions This chemical feature enables detection visualization and analysis of newly synthesized RNA molecules within biological systems Hence Thieno-CTP is utilized to examine transcriptional dynamics RNA synthetic regulation RNA trafficking and RNA-protein interaction studies supporting research into RNA biology and related areas
Apexbio Technology LLC Thieno-CTP 50ul (100 mM)
Thieno-CTP is a structural analog of cytidine triphosphate (CTP) that incorporates a thiophene-modified nucleobase allowing incorporation into RNA by RNA polymerases during transcription Following enzymatic incorporation into nascent RNA transcripts the introduced thienyl modification acts as a reactive site suitable for subsequent bioorthogonal labeling via selective chemical reactions This chemical feature enables detection visualization and analysis of newly synthesized RNA molecules within biological systems Hence Thieno-CTP is utilized to examine transcriptional dynamics RNA synthetic regulation RNA trafficking and RNA-protein interaction studies supporting research into RNA biology and related areas
Medchemexpress LLC (2S,4S)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl | 2380273-26-5 | MFCD32876834 | 98.6% | 481.05 g/mol | C23H33ClN4O3S | 500 MG
(2S,4S)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride is a research-grade small molecule supplied as the hydrochloride salt for biochemical and medicinal chemistry studies. It is characterized by a molecular formula C23H33ClN4O3S, molecular weight 481.05 g/mol, and LCMS purity 98.59%. Documentation available includes a certificate of analysis and a safety data sheet.
- Hydrochloride salt suitable for research use.
- Purity 98.6% (LCMS).
- Molecular weight 481.05 g/mol, formula C23H33ClN4O3S.
- Supplied with COA and SDS documentation.
- Recommended storage: -20°C, sealed, protected from moisture and light.