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N-Boc-dolaproine-amide-Me-Phe is an amino acid residue of the pentapeptide Dolastatin 10, which is known for its ability to inhibit tubulin polymerization and mitosis, demonstrating anticancer activity.
Amino acid residue of the pentapeptide Dolastatin 10.
Dolastatin 10 inhibits tubulin polymerization and mitosis.
Exhibits anticancer activity.
Intended for research use only.
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Human GIP(3-30), amide TFA is the TFA salt form of human GIP(3-30), amide (HY-P10138). It is a high affinity antagonist of the human GIP receptor in vitro. Human GIP(3-30), amide TFA has potential anti-obesity and anti-diabetic effects.
High affinity antagonist of the human GIP receptor in vitro.
Potential anti-obesity effects.
Potential anti-diabetic effects.
Competitively binds to GIP receptor (GIPR), blocking GIP-mediated cAMP accumulation (Ki=16.8 nM), β-arrestin recruitment (Ki for β-arrestin-1/2 recruitment is 10.6 nM and 10.2 nM) and receptor internalization.
Inhibits GIP mediated insulin secretion and signal transduction in adipocytes.
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