Thiophenes
Medchemexpress LLC Lomerizine dihydrochloride | 101477-54-7 | 99.9% | 100 MG
Lomerizine dihydrochloride is an antagonist of L- and T-type voltage-gated calcium channels. It is intended for research use only.
- Antagonist of L- and T-type voltage-gated calcium channels
- Neuroprotective in motor neurons
- Increases cerebral blood flow
- Reverses multidrug resistance by inhibiting P-gp function
Medchemexpress LLC 2-Amino-2-(thiophen-3-yl)acetic acid | 38150-49-1 | 157.19 | 100 MG
2-Amino-2-(thiophen-3-yl)acetic acid is a glycine derivative primarily used as an ergogenic supplement. It is recognized as a beneficial dietary substance that can influence anabolic hormone secretion, support fuel supply during exercise, enhance mental performance during stress, and help prevent exercise-induced muscle damage.
- Influences secretion of anabolic hormones
- Supplies fuel during exercise
- Enhances mental performance during stress-related tasks
- Prevents exercise-induced muscle damage
Medchemexpress LLC Chroman 1 dihydrochloride | 1273579-40-0 | MFCD23098792 | 99.1% | 509.43 | C24H30Cl2N4O4 | 10 MG
Chroman 1 dihydrochloride is a highly potent and selective Rho-associated protein kinase (ROCK) inhibitor, with markedly greater activity against ROCK2 than ROCK1. Supplied as a dihydrochloride solid salt with high purity and good solubility, it is used in biochemical and cellular studies to probe ROCK signaling pathways.
- Highly potent, selective ROCK2 inhibitor (IC50 1 pM).
- Also inhibits ROCK1 and MRCK (IC50 52 pM and 150 nM).
- High purity: 99.11%.
- Soluble in water and DMSO: 100 mg/mL.
- Supplied as a solid dihydrochloride salt for stability.
- Recommended storage: sealed and away from moisture; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC 2-Amino-2-(thiophen-3-yl)acetic acid | 38150-49-1 | 157.19 | 250 MG
2-Amino-2-(thiophen-3-yl)acetic acid is a Glycine derivative. Amino acids and their derivatives are commercially used as ergogenic supplements, influencing anabolic hormone secretion, fuel supply during exercise, mental performance during stress-related tasks, and preventing exercise-induced muscle damage. They are recognized as beneficial ergogenic dietary substances.
- Used as an ergogenic supplement
- Influences the secretion of anabolic hormones
- Supplies fuel during exercise
- Enhances mental performance during stress-related tasks
- Prevents exercise-induced muscle damage
Selleck Chemical LLC GSK-LSD1 2HCl
GSK-LSD1 2HCl is an irreversible and selective LSD1 inhibitor with IC50 of 16 nM 1000 fold selective over other closely related FAD utilizing enzymes (i e LSD2 MAO-A MAO-B)
Selleck Chemical LLC Trifluoperazine 2HCl S3201-10mM/1mL
Trifluoperazine (NSC-17474 RP-7623 SKF-5019) 2HCl is a dopamine D2 receptor inhibitor with IC50 of 1 1 nM Trifluoperazine also inhibits calmodulin (CaM)
Apexbio Technology LLC DMAB-anabaseine dihydrochloride 154149-38-9 10mg
DMAB-anabaseine dihydrochloride (CAS 154149-38-9) is a small-molecule partial agonist and antagonist targeting neuronal 7 nicotinic acetylcholine receptors (nAChRs) It is designed to modulate receptor-mediated neurotransmission thereby influencing cognitive-related neuronal signaling pathways DMAB-anabaseine dihydrochloride exerts its biological activity primarily through selective partial activation of 7 nAChRs and antagonism at other subtypes such as 4 2 Based on these pharmacological properties DMAB-anabaseine dihydrochloride holds research potential in studies of nicotinic receptor function neural signaling mechanisms and cognitive-related conditions
Apexbio Technology LLC Pramipexole dihydrochloride 104632-25-9 20mg
Pramipexole dihydrochloride is a small-molecule agonist targeting dopamine receptors exhibiting selective affinity toward the D3 dopamine receptor subtype and lower affinity for the D2L D2S and D4 subtypes It is designed to stimulate dopamine receptor-mediated signaling thereby modulating dopaminergic pathways involved in motor function Pramipexole dihydrochloride exerts its biological activity primarily through dopamine receptor agonism and also demonstrates receptor-independent neuroprotective effects by attenuating mitochondrial reactive oxygen species (ROS) production and decreasing apoptosis-related signaling cascades Based on these pharmacological properties pramipexole dihydrochloride holds research potential in exploring dopaminergic system involvement and neuroprotective mechanisms relevant to neurodegenerative conditions such as Parkinson s disease and restless legs syndrome
Medchemexpress LLC Merestinib dihydrochloride | 1206801-37-7 | 99.4% | 625.45 g·mol⁻¹ | C30H24Cl2F2N6O3 | 10 MG
Merestinib dihydrochloride is the dihydrochloride salt of merestinib (LY2801653), an orally bioavailable small-molecule multi-kinase inhibitor supplied for preclinical research. It potently inhibits c-Met and has reported activity against several oncogenic kinases, and is provided as a characterized reagent with supporting analytical data.
- Potent c-Met inhibitor with reported Ki ≈ 2 nM.
- Activity against multiple kinases including MST1R, FLT3, AXL, MERTK, TEK, ROS1, DDR1/2, and MKNK1/2.
- Orally bioavailable small-molecule suitable for in vitro and in vivo preclinical studies.
- Characterized reagent with molecular formula C30H24Cl2F2N6O3 and molecular weight 625.45 g·mol⁻¹.
- High purity confirmed by LCMS (≈99.4%).
Selleck Chemical LLC Latrepirdine 2HCl S1245-10mg
Latrepirdine is an orally active and neuroactive antagonist of multiple drug targets including histamine receptors GluR and 5-HT receptors used as an antihistamine drug
![eMolecules 6-AMINOBENZO[D][1,3]DIOXOLE-5-CARBOXYLIC ACID | 20332-16-5 | MFCD00016650 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502170303.JPG-250.jpg)
eMolecules 6-AMINOBENZO[D][1,3]DIOXOLE-5-CARBOXYLIC ACID | 20332-16-5 | MFCD00016650 | 1g
AstaTech | 6-AMINOBENZO[D][1,3]DIOXOLE-5-CARBOXYLIC ACID | 1g | 528280288 | 87187 | 95.000 | 20332-16-5 | MFCD00016650 | 181.147 | C8H7NO4
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Apexbio Technology LLC 4-Methylhistamine dihydrochloride 36376-47-3 1mg
4-Methylhistamine dihydrochloride (CAS 36376-47-3) is a selective agonist for the histamine H4 receptor (H4R) displaying a pEC50 of 7 4 0 1 at human H4R It exhibits over 100-fold selectivity for H4R relative to H3R and H2R and over 100 000-fold compared to H1R While affinity for human H4R is moderate it binds rat and mouse H4R with higher affinity (Ki values of 73 nM and 55 nM respectively) In in vivo models 4-Methylhistamine dihydrochloride modulates inflammatory signaling elevating TNF- and NF- B expression via JAK/STAT pathways in response to LPS-induced joint inflammation It serves as a valuable tool in studies of H4R-mediated immune regulation and inflammatory mechanisms
Medchemexpress LLC d-Atabrine dihydrochloride | 56100-41-5 | 99.6% | 472.88 | 1 ML
d-Atabrine dihydrochloride is an active enantiomer of quinacrine which displays antiprion activity.
- Purity of 99.64%
- Molecular weight of 472.88
- Appears as a solid
- Color is light yellow to yellow
- Recommended storage at 4°C, sealed, away from moisture
- For solutions, store at -80°C for 6 months or -20°C for 1 month, sealed and away from moisture
Medchemexpress LLC Meclizine dihydrochloride | 1104-22-9 | 99.9% | 5 G
Meclizine dihydrochloride is an antihistamine that reversibly inhibits histamine interaction at H1 receptors. It belongs to the piperazine class of H1 antagonists and is an effective anti-motion sickness agent. This compound can cross the blood-brain barrier and is used for research into polyQ toxicity disorders such as Huntington's disease. Meclizine dihydrochloride acts as an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR.
- Reversibly inhibits histamine at H1 receptors.
- Effective anti-motion sickness agent.
- Crosses the blood-brain barrier.
- Used for research of polyQ toxicity disorders, such as Huntington's disease.
- Agonist ligand for mouse constitutive androstane receptor (CAR).
- Inverse agonist for Human CAR.