Thiophenes
Medchemexpress LLC Nolatrexed dihydrochloride | 152946-68-4 | 98.5% | 357.26 | 50 MG
Nolatrexed dihydrochloride (AG 337) is an orally active and non-competitive lipophilic inhibitor of thymidylate synthase with a Ki of 11 nM for human thymidylate synthase. It interacts at the folate cofactor binding site of the enzyme. Nolatrexed dihydrochloride increases sulfotransferases and induces cell cycle arrest in the S phase of cancer cells. It also exhibits anticancer activity against cervical cancer.
- Orally active and non-competitive lipophilic inhibitor of thymidylate synthase.
- Interacts at the folate cofactor binding site of the enzyme.
- Increases sulfotransferases.
- Induces cell cycle arrest in the S phase of cancer cells.
- Exhibits anticancer activity against cervical cancer.
Advanced Chemblocks Inc 1-NONYLPIPERIDINE-4-CARBOXYL1G
1-Nonylpiperidine-4-carboxylic acid, 1g, 1156807-77-0
Medchemexpress LLC Ro 10-5824 dihydrochloride | 189744-94-3 | 99.9% | 353.29 g/mol | C17H22Cl2N4 | 10 MG
Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist used in neuroscience and receptor pharmacology research. It binds the D4 receptor with high affinity (Ki ≈ 5.2 nM), shows pronounced selectivity over other dopamine receptor subtypes, and produces partial agonist responses in functional assays; in vivo studies report effects on object recognition and frontal cortex gamma activity without altering spontaneous locomotion.
- High-affinity D4 receptor binding (Ki ≈ 5.2 nM).
- Pronounced selectivity versus other dopamine receptor subtypes.
- Partial agonist activity in functional assays (35S-GTPγS stimulation).
- Demonstrated in vivo activity relevant to cognition and neural oscillations.
- High chemical purity suitable for in vitro and in vivo research.
Apexbio Technology LLC Quinacrine 2HCl 69-05-6 50mg
Quinacrine 2HCl (69-05-6) is an orally active small-molecule inhibitor targeting the NF- B signaling pathway It is designed to inhibit the NF- B cascade thereby downregulating pro-survival gene expression and promoting apoptotic pathways in tumor cells Quinacrine 2HCl exerts its biological activity primarily through inhibition of NF- B and activation of the p53-dependent apoptotic pathway In in vitro studies Quinacrine 2HCl demonstrates growth inhibition of multiple cancer cell lines with reported IC50 values generally in the low micromolar range depending on the specific cell model and experimental context Based on these pharmacological properties Quinacrine 2HCl holds research potential in investigating apoptosis regulatory mechanisms NF- B pathway involvement in cancer biology and preclinical evaluation of potential anticancer therapies
Medchemexpress LLC Lesopitron dihydrochloride | 132449-89-9 | MFCD00894211 | 98.0% | 393.74 g/mol | C15H23Cl3N6 | 1 MG
Lesopitron dihydrochloride is a selective, full agonist of the serotonin 5-HT1A receptor used for preclinical in vitro pharmacology and receptor-binding studies. It shows an IC50 of 125 nM in rat hippocampal membranes and is supplied as the dihydrochloride salt at high purity for research use.
- High purity (98.0%).
- Molecular formula C15H23Cl3N6; molecular weight 393.74 g/mol.
- Selective 5-HT1A receptor agonist (IC50 = 125 nM in rat hippocampal membranes).
- Suitable for in vitro receptor pharmacology and binding assays.
- Available in small research pack sizes (e.g., 1 mg).
- Analytical documentation available (COA, HNMR, SDS).
Medchemexpress LLC Methyl 3-oxoheptanoa 10g
Methyl 3-oxoheptanoate is the methyl ester of the organic compound 3-oxoheptanoate It has a fruity smell and taste Methyl 3-oxoheptanoate is widely used as a flavoring agent and fragrance in the food and fragrance industry for its pleasant aroma It is also used as an intermediate in the synthesis of other organic compounds such as pharmaceuticals agrochemicals and polymers
Medchemexpress LLC 4-Aminobenzo-12-crown-4 | 78554-68-4 | 98.0% | C12H17NO4 | 250 MG
4-Aminobenzo-12-crown-4 is a chemical compound primarily utilized as a drug intermediate for the synthesis of various active compounds. This product is intended for research use only and has not been fully validated for medical applications.
- Used for the synthesis of various active compounds
- Store at 4°C, protected from light
- In solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light
- For research use only
Selleck Chemical LLC BGP-15 2HCl
BGP-15 is a nicotinic amidoxime derivative with PARP inhibitory activity It has been demonstrated that BGP-15 protects against ischemia-reperfusion injury
Medchemexpress LLC YM-244769 dihydrochloride | 1780390-65-9 | 516.39 | 1 ML
YM-244769 dihydrochloride | 1780390-65-9 | 516.39 | 1 ML
Selleck Chemical LLC H 89 2HCl S1582-50mg
H 89 2HCl is a potent PKA inhibitor with Ki of 48 nM in a cell-free assay 10-fold selective for PKA than PKG 500-fold greater selectivity than PKC MLCK calmodulin kinase II and casein kinase I/II H 89 2HCl induces autophagy
Selleck Chemical LLC TLR7/8 agonist 1 2HCl
TLR7/8 agonist 1 dihydrochloride is a toll-like receptor TLR7/TLR8 dual-agonistic imidazoquinoline TLR7/8 agonist 1 retains TLR7-agonistic activity with an EC50 of 20 nM
