Thiophenes
eMolecules Synthonix / 3-aminothiophene-2-carboxamide / 5g / 784552335 / AC77867 / / 147123-47-5 / MFCD00052593 / 142.180 / C5H6N2OS
Synthonix / 3-aminothiophene-2-carboxamide / 5g / 784552335 / AC77867 / / 147123-47-5 / MFCD00052593 / 142.180 / C5H6N2OS
Medchemexpress LLC UCM-13369 dihydrochloride | 99.87% | 462.46 | 5 MG
UCM-13369 (Compound 4b) is a NPM1 inhibitor. It downregulates the pathway associated with mutant NPM1 C+, and specifically recognizes the C-end DNA-binding domain of NPM1 C+. It induces apoptosis in AML cell lines and primary cells and can be used for leukemia research.
- Downregulates the pathway associated with mutant NPM1 C+.
- Specifically recognizes the C-end DNA-binding domain of NPM1 C+.
- Induces apoptosis in AML cell lines and primary cells.
- Can be used for leukemia research.
Medchemexpress LLC Chroman 1 dihydrochloride | C24H30Cl2N4O4 | 5 MG
Chroman 1 dihydrochloride is a highly potent and selective ROCK inhibitor, showing more potency against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM). It also exhibits inhibitory activity against MRCK, with an IC50 of 150 nM. In vitro studies indicate that Chroman 1 (50 nM, 24 h) inhibits caspase-3/7 activation and reduces apoptosis in human pluripotent stem cells.
- Highly potent and selective ROCK inhibitor
- More potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM)
- Inhibits MRCK (IC50=150 nM)
- Inhibits caspase-3/7 activation
- Reduces apoptosis in human pluripotent stem cells
![eMolecules THIENO[3,2-B]THIOPHEN-2-YLMETHANOL | 127025-34-7 | MFCD08059495 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502180630.JPG-250.jpg)
eMolecules THIENO[3,2-B]THIOPHEN-2-YLMETHANOL | 127025-34-7 | MFCD08059495 | 1g
AstaTech | THIENO[3,2-B]THIOPHEN-2-YLMETHANOL | 1g | 342445113 | 93745 | 95.000 | 127025-34-7 | MFCD08059495 | 170.240 | C7H6OS2
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Medchemexpress LLC Chroman 1 dihydrochloride | 1273579-40-0 | C24H30Cl2N4O4 | 25 MG
Chroman 1 dihydrochloride is a highly potent and selective ROCK inhibitor, demonstrating greater potency against ROCK2 (IC50=1 pM) compared to ROCK1 (IC50=52 pM). It also exhibits inhibitory activity against MRCK (IC50=150 nM) and has been shown to inhibit caspase-3/7 activation and reduce apoptosis in human pluripotent stem cells.
- Highly potent and selective ROCK inhibitor
- More potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM)
- Exhibits inhibitory activity against MRCK (IC50=150 nM)
- Inhibits caspase-3/7 activation
- Reduces apoptosis in human pluripotent stem cells
Medchemexpress LLC Methyl 3-oxohexanoate | 30414-54-1 | 144.17 | 10 G
Methyl 3-oxohexanoate (Methyl Butyrylacetate) is an organic compound commonly used in the manufacture of fragrances, drugs, and other chemicals. It functions as a condensation, diazotization, and addition reagent, playing a catalytic role in various organic synthesis reactions and drug synthesis.
- Used in the food industry for products like juices, beer, and confectionery.
- Functions as a condensation reagent.
- Functions as a diazotization reagent.
- Functions as an addition reagent.
- Catalytic role in organic synthesis reactions.
- Useful in drug synthesis.
- Biochemical reagent for life science-related research.
Apexbio Technology LLC NVP-BSK805 2HCl 1092499-93-8 (free base) 50mg
NVP-BSK805 2HCl is a selective ATP-competitive inhibitor targeting Janus kinase 2 (JAK2) JAK2 part of the JAK kinase family mediates signaling through cytokine receptor systems including type II cytokine GM-CSF receptor gp130 and single-chain receptor families By competitively binding the ATP-binding site of JAK2 NVP-BSK805 inhibits downstream STAT5 phosphorylation and JAK-mediated signaling It displays greater than 20-fold selectivity for JAK2 versus other JAK family members (JAK1 JAK3 TYK2) Cell-based assays demonstrate antiproliferative activity against cells expressing JAK2V617F mutations NVP-BSK805 is commonly employed in vitro and in vivo to investigate JAK2-mediated cellular responses oncogenesis and associated signaling pathways
Selleck Chemical LLC PRT-060318 2HCl
PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase with an IC50 of 4 nM as an approach to HIT treatment
Medchemexpress LLC Nolatrexed dihydrochloride | 152946-68-4 | 98.5% | 357.26 | 25 MG
Nolatrexed dihydrochloride (AG 337) is an orally active, non-competitive, lipophilic inhibitor of thymidylate synthase with a Ki of 11 nM for human thymidylate synthase. It interacts at the folate cofactor binding site of the enzyme, increases sulfotransferases, and induces cell cycle arrest in the S phase of cancer cells. It also exhibits anticancer activity against cervical cancer.
- Orally active and non-competitive lipophilic inhibitor of thymidylate synthase.
- Interacts at the folate cofactor binding site of the enzyme.
- Increases sulfotransferases.
- Induces cell cycle arrest in S phase of cancer cells.
- Exhibits anticancer activity against cervical cancer.
Medchemexpress LLC Ensartinib dihydrochloride | 2137030-98-7 | MFCD31657344 | 99.7% | 634.36 g/mol | C26H29Cl4FN6O3 | 1 ML
Ensartinib dihydrochloride is the dihydrochloride salt of ensartinib, a potent dual ALK and MET tyrosine kinase inhibitor used in preclinical research to investigate ALK-driven cancers and resistance mutations. It is supplied in high-purity solid and solution formats for laboratory use.
- Potent dual ALK and MET inhibition with sub-nanomolar IC50s.
- High purity (≈99.7%) suitable for analytical and in vitro use.
- Available as a 10 mM solution (1 mL) and multiple solid pack sizes.
- Soluble in DMSO for convenient stock preparation.
- Intended for preclinical kinase profiling and resistance mechanism studies.
Apexbio Technology LLC H 89 2HCl 130964-39-5 10mM (in 1mL DMSO)
H 89 2HCl (CAS 130964-39-5) is a small-molecule inhibitor targeting cyclic AMP-dependent protein kinase (PKA) It exhibits a Ki of approximately 48 nM toward PKA and demonstrates substantial selectivity compared to related kinases such as PKG (about 10-fold) PKC MLCK calmodulin kinase II and casein kinases (approximately 500-fold) In PC12D cells H 89 at micromolar concentrations suppresses forskolin-induced phosphorylation events and neurite outgrowth without altering intracellular cAMP levels Due to its selective inhibitory profile H 89 is widely utilized in cell signaling studies examining cAMP-dependent pathways