Thiophenes
Medchemexpress LLC UCM-13369 dihydrochloride | 99.9% | 462.46 | 25 MG
UCM-13369 (Compound 4b) is a NPM1 inhibitor. It downregulates the pathway associated with mutant NPM1 C+ and specifically recognizes the C-end DNA-binding domain of NPM1 C+. It induces apoptosis in AML cell lines and primary cells and can be used for leukemia research.
- NPM1 inhibitor
- Downregulates pathway associated with mutant NPM1 C+
- Specifically recognizes the C-end DNA-binding domain of NPM1 C+
- Induces apoptosis in AML cell lines and primary cells
- Can be used for leukemia research
Medchemexpress LLC Thiophene-2-amidoxim 1g | 108443-93-2 | 142.18 | C5H6N2OS | 1 G
Thiophene-2-amidoxime (CAS 108443-93-2) is a thiophene-derived amidoxime used as a synthetic intermediate in pharmaceutical and medicinal chemistry. It is supplied as a solid powder, typically white to off-white, with molecular formula C5H6N2OS and molecular weight 142.18 g/mol.
- Used as a synthetic intermediate in pharmaceutical synthesis.
- Solid powder, typically white to off-white.
- Molecular formula C5H6N2OS and molecular weight 142.18 g/mol.
- Suitable for building heterocyclic and bioactive molecules.
- Reported purity ≥97% from supplier specifications.
Cayman Chemical ThIophen-2-amIdoxIme 5g
A synthetic intermediate useful for pharmaceutical synthesis
Medchemexpress LLC Ensartinib dihydrochloride | 2137030-98-7 | MFCD31657344 | 99.7% | 634.36 g/mol | C26H29Cl4FN6O3 | 1 ML
Ensartinib dihydrochloride is the dihydrochloride salt of ensartinib, a potent dual ALK and MET tyrosine kinase inhibitor used in preclinical research to investigate ALK-driven cancers and resistance mutations. It is supplied in high-purity solid and solution formats for laboratory use.
- Potent dual ALK and MET inhibition with sub-nanomolar IC50s.
- High purity (≈99.7%) suitable for analytical and in vitro use.
- Available as a 10 mM solution (1 mL) and multiple solid pack sizes.
- Soluble in DMSO for convenient stock preparation.
- Intended for preclinical kinase profiling and resistance mechanism studies.
Medchemexpress LLC Methyl 3-(2-((tert-butoxycarbonyl)amino)ethyl)benzoate | 179003-02-2 | 279.34 | 10 G
Methyl 3-(2-((tert-butoxycarbonyl)amino)ethyl)benzoate is a drug intermediate used for the synthesis of various active compounds. This substance is intended for laboratory use.
- Used for synthesis of various active compounds.
- Stable under recommended storage conditions.
- Recommended storage conditions for powder: -20°C for 3 years, 4°C for 2 years.
Cayman Chemical 3 Arachidonic Acidmethyl es
A rare polyunsaturated fatty acid; a neutral, lipid-soluble form of the rare fatty acid ω-3 arachidonic acid
Medchemexpress LLC Dicarbine dihydrochloride | 33162-17-3 | 98.9% | 1 MG
Dicarbine dihydrochloride is a dopamine receptor blocker that blocks dopamine receptors in various brain parts. It prevents the depression of conditioned defense reflexes caused by stimulation of the mesencephalic portion of the reticular formation. This product could be used in schizophrenia and alcoholic psychosis studies.
- Blocks dopamine receptors in various brain parts.
- Prevents depression of conditioned defense reflexes.
- Suitable for schizophrenia and alcoholic psychosis studies.
Medchemexpress LLC Gyki 52466 dihydrochloride | 2319722-40-0 | 99.8% | 366.24 g·mol⁻1 | C17H17Cl2N3O2 | 100 MG
GYKI 52466 dihydrochloride is a research-grade small molecule antagonist selective for AMPA and kainate ionotropic glutamate receptors. It is orally active and noncompetitive, used in in vitro pharmacology, electrophysiology, and in vivo neuropharmacology studies.
- Selective noncompetitive AMPA/kainate receptor antagonist.
- Orally active with good blood-brain barrier permeability.
- High chemical purity suitable for research applications.
- Available in small milligram pack sizes for laboratory use.
- Store sealed, away from moisture and light; follow recommended cold storage for solutions.
eMolecules 6165-68-0 | (thiophen-2-yl)boronic acid | Key Organics/BIONET | MFCD00151850 | 127.950 | C4H5BO2S | 95.000 | OB(O)c1cccs1 | 50mg | 564105737
(thiophen-2-yl)boronic acid | Key Organics/BIONET | 6165-68-0 | MFCD00151850 | 127.950 | C4H5BO2S | 95.000 | OB(O)c1cccs1 | 50mg | 564105737
Medchemexpress LLC Lomerizine dihydrochloride | 101477-54-7 | 99.95% | 1 ML
Lomerizine dihydrochloride, also known as KB-2796, is a potent antagonist of L- and T-type voltage-gated calcium channels. This chemical is supplied at a concentration of 10mM in 1mL of DMSO. It is crucial for researchers studying calcium channel modulation and related neurological processes.
- Antagonist of L-type voltage-gated calcium channels
- Antagonist of T-type voltage-gated calcium channels
- Packaged as a 10mM solution in DMSO
- Recommended storage at 4°C, sealed, away from moisture
- Stable in solvent for 6 months at -80°C or 1 month at -20°C
- Suitable for shipping at room temperature for durations less than 2 weeks
![eMolecules 127025-34-7 | THIENO[3,2-B]THIOPHEN-2-YLMETHANOL | AstaTech | MFCD08059495 | 170.240 | C7H6OS2 | 95.000 | OCc1cc2sccc2s1 | 1g | 342445113](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502180630.JPG-250.jpg)
eMolecules 127025-34-7 | THIENO[3,2-B]THIOPHEN-2-YLMETHANOL | AstaTech | MFCD08059495 | 170.240 | C7H6OS2 | 95.000 | OCc1cc2sccc2s1 | 1g | 342445113
THIENO[3,2-B]THIOPHEN-2-YLMETHANOL | AstaTech | 127025-34-7 | MFCD08059495 | 170.240 | C7H6OS2 | 95.000 | OCc1cc2sccc2s1 | 1g | 342445113
Medchemexpress LLC Alexidine dihydrochloride | 1715-30-6 | ≥98% | 581.71 | 1 ML
Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells, leading to mitochondrial apoptosis. It also exhibits broad-spectrum antifungal and antibiofilm activity against various fungal pathogens, including fluconazole-resistant strains and mature biofilms.
- Targets mitochondrial tyrosine phosphatase (PTPMT1).
- Induces mitochondrial apoptosis.
- Shows broad-spectrum antifungal activity against diverse fungal pathogens.
- Effective against fluconazole-resistant Candida isolates.
- Inhibits filamentation and proliferation of fungi.
- Decimates mature biofilms of Candida, Cryptococcus, and Aspergillus species at low concentrations.
- Inhibits lateral yeast formation and biofilm dispersal in C. albicans.
- Reduces fungal biofilm growth and viability by 67% in C. albicans murine models.
Medchemexpress LLC DDP-38003 dihydrochloride | 1831167-98-6 | 99.3% | 423.38 | 50 MG
DDP-38003 dihydrochloride is a novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM. It demonstrates significant in vitro and in vivo efficacy, inhibiting KDM1A and reducing colony forming ability in THP-1 cells. In mouse leukemia models, oral administration of DDP-38003 dihydrochloride led to increased survival.
- Inhibits histone lysine-specific demethylase 1A (KDM1A/LSD1)
- Orally available
- IC50 of 84 nM for KDM1A
- Reduces colony forming ability and induces differentiation of THP-1 cells
- Shows in vivo efficacy in mouse leukemia models
- Potential oral anticancer agent
Medchemexpress LLC 5-Methyl-2-thiophenecarboxaldehyde | 13679-70-4 | 99.9% | 126.18 | 100 G
5-Methyl-2-thiophenecarboxaldehyde acts as a candidate to microscopic third order non-linear optical (NLO) material. It is also an analytical standard intended for research and analytical applications.
- Acts as a candidate to microscopic third order non-linear optical (NLO) material.
- Analytical standard for research and analytical applications.
Aobchem (5-Bromo-2-fluoro-3-(methylthio)phenyl)(cyclopropyl)methanone | 97% | C11H10BrFOS | 1g
(5-Bromo-2-fluoro-3-(methylthio)phenyl)(cyclopropyl)methanone | 97% | C11H10BrFOS | 1g