Thiophenes
Medchemexpress LLC Ucm-13369 (dihydrochloride) | 99.9% | 462.46 g/mol | C25H33Cl2N3O | 10 MG
UCM-13369 dihydrochloride is a research-grade small-molecule inhibitor of nucleophosmin 1 (NPM1) used for in vitro studies of apoptosis and AML-related pathways. It is supplied as a solid with confirmed high purity and solubility properties for DMSO stock preparation.
- Inhibits NPM1-associated pathways and induces apoptosis in AML models.
- High purity (99.87%) suitable for research applications.
- Available in multiple pack sizes, including 10 mg.
- Soluble in DMSO at 200 mg/mL for stock solution preparation.
- Powder stable at -20°C for long-term storage; solutions require cold storage.
Accela Chembio Inc Methyl 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylate | 5g | 91076-93-6 | MFCD00052591 | 97+% | Shelf Life: 2160 Days | Light Sensitive
Methyl 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylate | 5g | 91076-93-6 | MFCD00052591 | 97+% | Shelf Life: 2160 Days | Light Sensitive
Accela Chembio Inc 5-methyl-2-thiophenecarboxaldehyde | 100g | 13679-70-4 | MFCD00005434 | 98% | D: 1.17 | Shelf Life: 1800 Days | Light Sensitive/nitrogen Or Argon/+4
5-methyl-2-thiophenecarboxaldehyde | 100g | 13679-70-4 | MFCD00005434 | 98% | D: 1.17 | Shelf Life: 1800 Days | Light Sensitive/nitrogen Or Argon/+4
Accela Chembio Inc Methyl 3-amino-4-methylthiophene-2-carboxylate | 25g | 85006-31-1 | MFCD00051822 | 97+% | Shelf Life: 1260 Days | Light Sensitive/+4
Methyl 3-amino-4-methylthiophene-2-carboxylate | 25g | 85006-31-1 | MFCD00051822 | 97+% | Shelf Life: 1260 Days | Light Sensitive/+4
Medchemexpress LLC Azido-peg2-hydrazide-boc | 2100306-56-5 | MFCD30828695 | 95% | C12H23N5O5 | 100 MG
Azido-PEG2-hydrazide-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. It acts as a click chemistry reagent, featuring an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- Utilized in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC Upacicalcet sodium | 2052969-18-1 | 99.9% | 373.75 | 1 ML
Upacicalcet sodium | 2052969-18-1 | 99.9% | 373.75 | 1 ML
Medchemexpress LLC RP101988 | 2990018-57-8 | 98.8% | 418.45 | 100 MG
RP101988 is the major active metabolite of Ozanimod. It is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist.
- Selective and potent S1PR1 agonist
- EC50s of 0.19 nM for S1PR1 and 32.8 nM for S1PR5
- Substrate of P-gp and BCRP drug transporters
- For research use only
Medchemexpress LLC Seltorexant | 1293281-49-8 | 99.8% | 407.44 | 50 MG
Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). It crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain.
- Target: Orexin-2 Receptor (OX2R)
- Activity: Orally active, high-affinity, and selective antagonist
- Brain permeability: Crosses the blood-brain barrier and rapidly occupies OX2R binding sites in the rat brain
- Purity: 99.83%
- Form: Solid
- Color: White to yellow
- Research use: Used for research purposes
- Sleep-promoting effects: Dose-dependently induces and prolongs sleep in male Sprague-Dawley rats, with effects maintained upon 7-day repeated dosing.
Medchemexpress LLC RWJ-56110 dihydrochloride | 2387505-58-8 | 99.9% | 863.65 | 1 ML
RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor that targets PAR-1 activation and internalization, with a binding IC50 of 0.44 μM. It does not affect PAR-2, PAR-3, or PAR-4. This compound inhibits the aggregation of human platelets induced by SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), demonstrating selectivity compared to U46619. Additionally, RWJ-56110 dihydrochloride blocks angiogenesis by preventing new vessel formation in vivo and has been shown to induce cell apoptosis.
- It is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization.
- It shows no effect on PAR-2, PAR-3, or PAR-4.
- It inhibits the aggregation of human platelets induced by SFLLRN-NH2 and thrombin.
- It blocks angiogenesis and the formation of new vessels in vivo.
- It induces cell apoptosis.
Medchemexpress LLC Nolatrexed dihydrochloride | 152946-68-4 | 98.5% | 357.26 | 1 ML
Nolatrexed dihydrochloride is an orally active, non-competitive lipophilic inhibitor of thymidylate synthase. It interacts at the folate cofactor binding site of the enzyme, increases sulfotransferases, and induces cell cycle arrest in the S phase of cancer cells. It also exhibits anticancer activity against cervical cancer.
- Orally active
- Non-competitive lipophilic inhibitor of thymidylate synthase (Ki of 11 nM for human thymidylate synthase)
- Interacts at the folate cofactor binding site of the enzyme
- Increases sulfotransferases
- Induces cell cycle arrest in S phase of cancer cells
- Exhibits anticancer activity against cervical cancer
Medchemexpress LLC Alexidine (dihydrochloride) | 1715-30-6 | 99.7% | 581.71 | 250 MG
Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. It also exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens.
- Anticancer agent targeting PTPMT1.
- Causes mitochondrial apoptosis.
- Exhibits antifungal and antibiofilm activity against diverse fungal pathogens.
- Effective against most Candida spp. with low MIC values.
- Inhibits filamentation and proliferation of imaged fungi.
- Decimates mature biofilms of Candida, Cryptococcus, and Aspergillus spp. at low concentrations.
- Inhibits lateral yeast formation and biofilm dispersal.
- Significantly reduces the density of C. albicans biofilms in jugular vein catheters of mice.