Thiophenes
Medchemexpress LLC YM-244769 dihydrochloride | 1780390-65-9 | 516.39 | 1 ML
YM-244769 dihydrochloride | 1780390-65-9 | 516.39 | 1 ML
Medchemexpress LLC 5-Methyl-2-thiophenecarboxaldehyde | 13679-70-4 | 99.9% | 126.18 | 100 G
5-Methyl-2-thiophenecarboxaldehyde acts as a candidate to microscopic third order non-linear optical (NLO) material. It is also an analytical standard intended for research and analytical applications.
- Acts as a candidate to microscopic third order non-linear optical (NLO) material.
- Analytical standard for research and analytical applications.
Apexbio Technology LLC Cy5.5 hydrazide (non-sulfonated) 50mg
Cy5 5 hydrazide (non-sulfonated) is a near-infrared fluorescent dye with excitation and emission wavelengths around 675 nm and 694 nm respectively Structurally the hydrazide functional group of this dye readily reacts with carbonyl-containing compounds such as aldehydes and ketones via hydrazone formation In biological research this chemical reaction is frequently utilized for labeling biomolecules for example carbohydrates on antibodies can be oxidized with periodate to generate reactive aldehydes subsequently enabling Cy5 5 hydrazide conjugation through stable hydrazone linkages Due to its near-infrared emission characteristics Cy5 5 hydrazide exhibits efficient tissue penetration and low background fluorescence making it applicable to in vivo imaging studies immunological assays and biomolecule labeling workflows in biomedical applications
Medchemexpress LLC 2-Thiophenemethanol | 636-72-6 | 5454 | 99.8% | 114.17 | 500 G
2-Thiophenemethanol is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is for research use only.
- Can be stored at 4°C, protected from light.
- Stable in solvent at -80°C for 6 months.
- Stable in solvent at -20°C for 1 month.
- Forms clear solutions in various solubility protocols.
eMolecules 60729-37-5 | 4-Bromo-5-chlorothiophene-2-carboxylic acid | MFCD00847582 | 1g
Ambeed | 4-Bromo-5-chlorothiophene-2-carboxylic acid | 1g | 552568063 | A134383 | 60729-37-5 | MFCD00847582 | 241.480 | C5H2BrClO2S
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Medchemexpress LLC Anatabine Dicitrate | 99.03% | 544.46 | 100 MG
Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. It acts as a potent α4β2 nAChR agonist and inhibits NF-κB activation, thereby lowering amyloid-β (Aβ) production by preventing the β-cleavage of amyloid precursor protein (APP).
- Possesses anti-inflammatory effects
- Shows potential for treating neurodegenerative disorders
- Inhibits p65 NF-κB phosphorylation
- Prevents increase in BACE-1 mRNA levels
- Inhibits Aβ1-40 and Aβ1-42 in 7W CHO cells
- Lowers brain soluble Aβ1-40 and Aβ1-42 levels in a transgenic mouse model of Alzheimer's disease
Medchemexpress LLC Acetyl-CoA carboxylase-IN-1 | 179343-23-8 | MFCD12828288 | 99.2% | 395.05 g·mol⁻¹ | C13H9Br2N5 | 10 MG
Acetyl-CoA Carboxylase-IN-1 is a potent small-molecule inhibitor of acetyl-CoA carboxylase used for biochemical and microbiology research. It displays potent ACC inhibition (IC50 ≈ 5 nM) and reported antibacterial activity against Escherichia coli under defined in vitro assay conditions. The material is supplied as a solid (off-white to light yellow) for research use only and should be stored and handled according to the supplier's SDS.
- Potent ACC inhibitor with IC50 ≈ 5 nM.
- Antibacterial activity reported against Escherichia coli in vitro.
- Chemical identifiers: CAS 179343-23-8; formula C13H9Br2N5; MW 395.05 g·mol⁻¹.
- High purity (manufacturer-reported ~99.18%).
- Available in small research pack sizes (e.g., 10 mg) as a solid.
- Recommended storage: powder -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (up to 6 months).
Medchemexpress LLC Ucm-13369 (dihydrochloride) | 99.9% | 462.46 g/mol | C25H33Cl2N3O | 10 MG
UCM-13369 dihydrochloride is a research-grade small-molecule inhibitor of nucleophosmin 1 (NPM1) used for in vitro studies of apoptosis and AML-related pathways. It is supplied as a solid with confirmed high purity and solubility properties for DMSO stock preparation.
- Inhibits NPM1-associated pathways and induces apoptosis in AML models.
- High purity (99.87%) suitable for research applications.
- Available in multiple pack sizes, including 10 mg.
- Soluble in DMSO at 200 mg/mL for stock solution preparation.
- Powder stable at -20°C for long-term storage; solutions require cold storage.
Medchemexpress LLC Upacicalcet sodium | 2052969-18-1 | 99.9% | 373.75 | 1 ML
Upacicalcet sodium | 2052969-18-1 | 99.9% | 373.75 | 1 ML
Apexbio Technology LLC Clozapine N-oxide(CNO) dihydrochloride(Synonyms: CNO dihydrochloride, Clozapine N-oxide hydrochloride,Clozapine N-oxide dihydrochloride), 25mg, CAS: 2250025-93-3.
Clozapine N-oxide (CNO) dihydrochloride (CAS 2250025-93-3) is a synthetic metabolite derived from clozapine commonly utilized as an agonist for designer receptors exclusively activated by designer drugs (DREADDs) In neuroscience research CNO selectively binds and activates engineered muscarinic receptors particularly hM3Dq and hM4Di thereby influencing neuronal signaling upon penetrating the blood-brain barrier Due to its specificity CNO dihydrochloride serves as a valuable tool for dissecting neuronal circuits and elucidating their functional roles in behavioral studies
eMolecules 69363-85-5 | Methyl 4-aminothiophene-3-carboxylate | MFCD00130102 | 1g
Ambeed | Methyl 4-aminothiophene-3-carboxylate | 1g | 600833576 | A202435 | 69363-85-5 | MFCD00130102 | 157.190 | C6H7NO2S
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Medchemexpress LLC DDP-38003 dihydrochloride | 1831167-98-6 | 99.3% | 423.38 | 50 MG
DDP-38003 dihydrochloride is a novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM. It demonstrates significant in vitro and in vivo efficacy, inhibiting KDM1A and reducing colony forming ability in THP-1 cells. In mouse leukemia models, oral administration of DDP-38003 dihydrochloride led to increased survival.
- Inhibits histone lysine-specific demethylase 1A (KDM1A/LSD1)
- Orally available
- IC50 of 84 nM for KDM1A
- Reduces colony forming ability and induces differentiation of THP-1 cells
- Shows in vivo efficacy in mouse leukemia models
- Potential oral anticancer agent
Apexbio Technology LLC PX-478 2HCl 685898-44-6 10mM (in 1mL DMSO)
PX-478 2HCl (CAS 685898-44-6) commonly known as PX-478 is a small molecule inhibitor targeting hypoxia-inducible factor-1 (HIF-1 ) a transcription factor involved in regulating cellular responses to hypoxic stress including glycolysis angiogenesis and erythropoiesis PX-478 reduces HIF-1 protein levels in multiple tumor cell lines under both normoxic and hypoxic conditions demonstrating IC50 values around 20-30 M depending on cell type In xenograft studies with C6 tumor-bearing mice oral administration of PX-478 inhibited HIF-1 transcriptional activity within tumor hypoxic zones PX-478 is utilized as a research tool to examine hypoxia-related tumor biology and to explore therapeutic sensitization strategies
Apexbio Technology LLC Clozapine N-oxide(CNO) dihydrochloride(Synonyms: CNO dihydrochloride, Clozapine N-oxide hydrochloride,Clozapine N-oxide dihydrochloride), 5mg, CAS: 2250025-93-3.
Clozapine N-oxide (CNO) dihydrochloride (CAS 2250025-93-3) is a synthetic metabolite derived from clozapine commonly utilized as an agonist for designer receptors exclusively activated by designer drugs (DREADDs) In neuroscience research CNO selectively binds and activates engineered muscarinic receptors particularly hM3Dq and hM4Di thereby influencing neuronal signaling upon penetrating the blood-brain barrier Due to its specificity CNO dihydrochloride serves as a valuable tool for dissecting neuronal circuits and elucidating their functional roles in behavioral studies