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Meclizine dihydrochloride is an antihistamine that reversibly inhibits histamine interaction at H1 receptors. It belongs to the piperazine class of H1 antagonists and is an effective anti-motion sickness agent. This compound can cross the blood-brain barrier and is used for research into polyQ toxicity disorders such as Huntington's disease. Meclizine dihydrochloride acts as an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR.
Reversibly inhibits histamine at H1 receptors.
Effective anti-motion sickness agent.
Crosses the blood-brain barrier.
Used for research of polyQ toxicity disorders, such as Huntington's disease.
Agonist ligand for mouse constitutive androstane receptor (CAR).
Inverse agonist for Human CAR.
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