Thiophenes
Apexbio Technology LLC NVP-BSK805 2HCl 1092499-93-8 (free base) 50mg
NVP-BSK805 2HCl is a selective ATP-competitive inhibitor targeting Janus kinase 2 (JAK2) JAK2 part of the JAK kinase family mediates signaling through cytokine receptor systems including type II cytokine GM-CSF receptor gp130 and single-chain receptor families By competitively binding the ATP-binding site of JAK2 NVP-BSK805 inhibits downstream STAT5 phosphorylation and JAK-mediated signaling It displays greater than 20-fold selectivity for JAK2 versus other JAK family members (JAK1 JAK3 TYK2) Cell-based assays demonstrate antiproliferative activity against cells expressing JAK2V617F mutations NVP-BSK805 is commonly employed in vitro and in vivo to investigate JAK2-mediated cellular responses oncogenesis and associated signaling pathways
