9-Decyn-1-ol is an alkyl/ether-based PROTAC linker used in the synthesis of PROTACs. It can be conjugated with GDC-0068 and Lenalidomide to form INY-03-041, a potent, highly selective, and PROTAC-based pan-Akt degrader. It also functions as a click chemistry reagent due to its Alkyne group.
- Alkyl/ether-based PROTAC linker
- Used in the synthesis of PROTACs
- Can form INY-03-041, a pan-Akt degrader
- Inhibits Akt1, Akt2, and Akt3
- Click chemistry reagent with an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)