Nitrogen mustard compounds
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Medchemexpress LLC MS4077 | 2230077-10-6 | 99.7% | 1134.73 | 10 MG
MS4077 is an anaplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 37 nM for binding affinity to ALK. It is for research use only and not sold to patients.
- Effectively inhibits cancer cell proliferation.
- Concentration-dependently inhibits proliferation of SU-DHL-1 cells with an IC50 of 46 ± 4 nM.
- Potently reduces ALK fusion protein levels and inhibits ALK auto-phosphorylation and downstream STAT3 phosphorylation in SU-DHL-1 and NCI-H2228 cells.
- Reduces NPM-ALK protein levels with a DC50 of 3 ± 1 nM in SU-DHL-1 cells after 16-hour treatment.
- Achieves over 90% inhibition of both ALK Y1507 and STAT3 Y705 phosphorylation at 100 nM concentration.
- Reduces EML4-ALK protein levels with a DC50 of 34 ± 9 nM in NCI-H2228 cells after 16-hour treatment, with over 90% reduction at 100 nM.
