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Primary amines

Organic compounds and functional groups that contain a basic nitrogen atom with a lone pair. Primary amines have a nitrogen atom bonded to two hydrogen atoms, and a carbon atom or other functional group.

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Medchemexpress LLC 3(2H)-Pyridazinone, 6-[3-fluoro-4-(4-morpholinyl)phenyl]-4,5-dihydro-5-methyl-, (5R)- | 1630760-75-6 | 98.4% | 291.32 | 50 MG
SDP

BRD9500 is an orally active phosphodiesterases 3 (PDE3) inhibitor, demonstrating IC50s of 10 nM for PDE3A and 27 nM for PDE3B. This compound exhibits significant antitumor activity, primarily by inhibiting PDE3A and PDE3B, leading to cancer cell killing through the induction of PDE3A/B interactions with SFLN12.

  • Orally active PDE3 inhibitor
  • Potently inhibits PDE3A (IC50: 10 nM) and PDE3B (IC50: 27 nM)
  • Exhibits antitumor activity
  • Induces PDE3A/B interactions with SFLN12 to kill cancer cells
  • Shows an EC50 of 1 nM for SK-MEL-3 melanoma cell line viability
  • Demonstrates an EC50 of 1.6 nM for HeLa cell viability
  • Stabilizes the PDE3A-SLFN12 interaction in HeLa cells
  • Inhibits SK-MEL-3 melanoma growth in mice

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